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Read the July 15 issue
The cover shows an ovarian cancer tissue section from a patient harboring a rare PD-L1 tumor genetic rearrangement. For details, see article by Bellone and colleagues.
Translational Cancer Mechanisms and Therapy
Read, The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression, Lu Huang, et al.
CCR Translations
Read, Biomarker Discovery from We to Me: Is Learning from Each Patient a New Approach?, Stephanie Lheureux.
New Clinical Cancer Research Deputy Editor!
Read about Dr. Jean-Charles Soria in his Researcher Behind the Journals profile!

From the Current Issue

Translational Cancer Mechanisms and Therapy | AuthorChoice

The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression

Lu Huang, Shruti Malu, Jodi A. McKenzie, Miles C. Andrews, Amjad H. Talukder, Trang Tieu, Tatiana Karpinets, Cara Haymaker, Marie-Andrée Forget, Leila J. Williams, Zhe Wang, Rina M. Mbofung, Zhi-Qiang Wang, Richard Eric Davis, Roger S. Lo, Jennifer A. Wargo, Michael A. Davies, Chantale Bernatchez, Timothy Heffernan, Rodabe N. Amaria, Anil Korkut, Weiyi Peng, Jason Roszik, Gregory Lizée, Scott E. Woodman and Patrick Hwu

Clin Cancer Res July 15 2018 24 (14) 3366-3376; DOI:10.1158/1078-0432.CCR-17-2483
Translational Cancer Mechanisms and Therapy | AuthorChoice

BRAF and MEK Inhibitors Increase PD-1-Positive Melanoma Cells Leading to a Potential Lymphocyte-Independent Synergism with Anti–PD-1 Antibody

Martina Sanlorenzo, Igor Vujic, Arianna Floris, Mauro Novelli, Loretta Gammaitoni, Lidia Giraudo, Marco Macagno, Valeria Leuci, Ramona Rotolo, Chiara Donini, Marco Basiricò, Pietro Quaglino, Maria Teresa Fierro, Silvia Giordano, Maria Sibilia, Fabrizio Carnevale-Schianca, Massimo Aglietta and Dario Sangiolo

Clin Cancer Res July 15 2018 24 (14) 3377-3385; DOI:10.1158/1078-0432.CCR-17-1914
Precision Medicine and Imaging

Prevalent Homozygous Deletions of Type I Interferon and Defensin Genes in Human Cancers Associate with Immunotherapy Resistance

Zhenqing Ye, Haidong Dong, Ying Li, Tao Ma, Haojie Huang, Hon Sing Leong, Jeanette Eckel-Passow, Jean-Pierre A. Kocher, Han Liang and Liguo Wang

Clin Cancer Res July 15 2018 24 (14) 3299-3308; DOI:10.1158/1078-0432.CCR-17-3008
Clinical Trials: Immunotherapy

A Model of Overall Survival Predicts Treatment Outcomes with Atezolizumab versus Chemotherapy in Non–Small Cell Lung Cancer Based on Early Tumor Kinetics

Laurent Claret, Jin Y. Jin, Charles Ferté, Helen Winter, Sandhya Girish, Mark Stroh, Pei He, Marcus Ballinger, Alan Sandler, Amita Joshi, Achim Rittmeyer, David Gandara, Jean-Charles Soria and René Bruno

Clin Cancer Res July 15 2018 24 (14) 3292-3298; DOI:10.1158/1078-0432.CCR-17-3662

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