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Read the August 15 issue
About the cover: The cover shows INFγ production by activated T cells in a section of biopsied tumor tissue. For details, see the article by Subbiah and colleagues.
Translational Cancer Mechanisms and Therapy
Read, Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma, Joseph J. Caumanns, et al.
Review
Read, T-cell Dysfunction in Glioblastoma: Applying a New Framework, Karolina I. Woroniecka, et al.
CCR Translations
Read, Targeted Therapies for Brain Tumors: Will They Ever Deliver?, Michael A. Vogelbaum.

From the Current Issue

Precision Medicine and Imaging

Interferon Gamma Messenger RNA Signature in Tumor Biopsies Predicts Outcomes in Patients with Non–Small Cell Lung Carcinoma or Urothelial Cancer Treated with Durvalumab

Brandon W. Higgs, Christopher A. Morehouse, Katie Streicher, Philip Z. Brohawn, Fernanda Pilataxi, Ashok Gupta and Koustubh Ranade

Clin Cancer Res August 15 2018 24 (16) 3857-3866; DOI:10.1158/1078-0432.CCR-17-3451
Precision Medicine and Imaging

21-Gene Recurrence Score Assay Predicts Benefit of Post-Mastectomy Radiotherapy in T1-2 N1 Breast Cancer

Chelain R. Goodman, Brandon-Luke L. Seagle, Masha Kocherginsky, Eric D. Donnelly, Shohreh Shahabi and Jonathan B. Strauss

Clin Cancer Res August 15 2018 24 (16) 3878-3887; DOI:10.1158/1078-0432.CCR-17-3169
Translational Cancer Mechanisms and Therapy

Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma

Joseph J. Caumanns, Katrien Berns, G. Bea A. Wisman, Rudolf S.N. Fehrmann, Tushar Tomar, Harry Klip, Gert J. Meersma, E. Marielle Hijmans, Annemiek M.C. Gennissen, Evelien W. Duiker, Desiree Weening, Hiroaki Itamochi, Roelof J.C. Kluin, Anna K.L. Reyners, Michael J. Birrer, Helga B. Salvesen, Ignace Vergote, Els van Nieuwenhuysen, James Brenton, E. Ioana Braicu, Jolanta Kupryjanczyk, Beata Spiewankiewicz, Lorenza Mittempergher, René Bernards, Ate G.J. van der Zee and Steven de Jong

Clin Cancer Res August 15 2018 24 (16) 3928-3940; DOI:10.1158/1078-0432.CCR-17-3060
Translational Cancer Mechanisms and Therapy

ΔNp63γ/SRC/Slug Signaling Axis Promotes Epithelial-to-Mesenchymal Transition in Squamous Cancers

Kirtiman Srivastava, Adam Pickard, Stephanie G. Craig, Gerard P. Quinn, Shauna M. Lambe, Jacqueline A. James, Simon S. McDade and Dennis J. McCance

Clin Cancer Res August 15 2018 24 (16) 3917-3927; DOI:10.1158/1078-0432.CCR-17-3775

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