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Read the April 15 issue
About the cover: The cover shows a mixed urothelial and small cell carcinoma. Deep sequencing of macrodissected urothelial and small-cell components revealed truncal mutations clonal in both components. See article by Chang et al.
CCR Translations
Read: Small-Cell Neuroendocrine Tumors: Cell State Trumps the Oncogenic Driver, Matthew G. Oser, et al.
Biology of Human Tumors
Read: Small-Cell Carcinomas of the Bladder and Lung Are Characterized by a Convergent but Distinct Pathogenesis, Matthew T. Chang, et al.
Immunotherapy Series
Read the articles in the Clinical Cancer Research Immunotherapy: Facts and Hopes series
New Collection!
Just released, read the updated Clinical Cancer Research Clinical Trials collection

From the Current Issue

Cancer Therapy: Clinical | AuthorChoice

Phase I Study of Single-Agent Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Patients with Advanced Cancer

Neil H. Segal, Aiwu R. He, Toshihiko Doi, Ronald Levy, Shailender Bhatia, Michael J. Pishvaian, Rossano Cesari, Ying Chen, Craig B. Davis, Bo Huang, Aron D. Thall and Ajay K. Gopal

Clin Cancer Res April 15 2018 24 (8) 1816-1823; DOI:10.1158/1078-0432.CCR-17-1922
Biology of Human Tumors

Wide Expression and Significance of Alternative Immune Checkpoint Molecules, B7x and HHLA2, in PD-L1–Negative Human Lung Cancers

Haiying Cheng, Alain Borczuk, Murali Janakiram, Xiaoxin Ren, Juan Lin, Amer Assal, Balazs Halmos, Roman Perez-Soler and Xingxing Zang

Clin Cancer Res April 15 2018 24 (8) 1954-1964; DOI:10.1158/1078-0432.CCR-17-2924
Cancer Therapy: Clinical

Induction Chemotherapy plus Concurrent Chemoradiotherapy in Endemic Nasopharyngeal Carcinoma: Individual Patient Data Pooled Analysis of Four Randomized Trials

Yu-Pei Chen, Ling-Long Tang, Qi Yang, Sharon-Shuxian Poh, Edwin P. Hui, Anthony T.C. Chan, Whee-Sze Ong, Terence Tan, Joseph Wee, Wen-Fei Li, Lei Chen, Brigette B.Y. Ma, Macy Tong, Sze-Huey Tan, Shie-Lee Cheah, Kam-Weng Fong, Kiattisa Sommat, Yoke Lim Soong, Ying Guo, Ai-Hua Lin, Ying Sun, Ming-Huang Hong, Su-Mei Cao, Ming-Yuan Chen and Jun Ma

Clin Cancer Res April 15 2018 24 (8) 1824-1833; DOI:10.1158/1078-0432.CCR-17-2656
Personalized Medicine and Imaging | AuthorChoice

HER3-Mediated Resistance to Hsp90 Inhibition Detected in Breast Cancer Xenografts by Affibody-Based PET Imaging

Carlos D. Martins, Chiara Da Pieve, Thomas A. Burley, Rhodri Smith, Daniela M. Ciobota, Louis Allott, Kevin J. Harrington, Wim J.G. Oyen, Graham Smith and Gabriela Kramer-Marek

Clin Cancer Res April 15 2018 24 (8) 1853-1865; DOI:10.1158/1078-0432.CCR-17-2754

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