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Read the June 15 issue
About the cover: A section of an oropharynx tumor from a patient with HPV-associated head and neck cancer is shown. Immunohistochemical staining shows strong membranous HER3 expression in a small area of the tumor. See article by Brand and colleagues.
Highlight
Read: Histone Deacetylase 3 Inhibition Overcomes BIM Deletion Polymorphism–Mediated Osimertinib Resistance in EGFR-Mutant Lung Cancer, Azusa Tanimoto, et al.
Commentary
Read: The “Tricky Business” of Identifying Mechanisms of Resistance to Anti–PD-1, James S. Wilmott, et al.
New Series!
Read the newly published articles in a continuing series from the AACR Childhood Cancer Predisposition Workshop. Check back for additional, relevant content and updated recommendations.
Hot off the press!
Read: PD-L2 Expression in Human Tumors: Relevance to Anti-PD-1 Therapy in Cancer,Jennifer H. Yearley, et al.

From the Current Issue

Biology of Human Tumors

Histone Deacetylase 3 Inhibition Overcomes BIM Deletion Polymorphism–Mediated Osimertinib Resistance in EGFR-Mutant Lung Cancer

Azusa Tanimoto, Shinji Takeuchi, Sachiko Arai, Koji Fukuda, Tadaaki Yamada, Xavier Roca, S. Tiong Ong and Seiji Yano

Clin Cancer Res June 15 2017 23 (12) 3139-3149; DOI:10.1158/1078-0432.CCR-16-2271
Biology of Human Tumors

Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies B2M Inactivation Impairing Immunorecognition

Carolina Pereira, Pol Gimenez-Xavier, Eva Pros, Maria J. Pajares, Massimo Moro, Antonio Gomez, Alejandro Navarro, Enric Condom, Sebastian Moran, Gonzalo Gomez-Lopez, Osvaldo Graña, Miriam Rubio-Camarillo, Alex Martinez-Martí, Jun Yokota, Julian Carretero, Jose M. Galbis, Ernest Nadal, David Pisano, Gabriella Sozzi, Enriqueta Felip, Luis M. Montuenga, Luca Roz, Alberto Villanueva and Montse Sanchez-Cespedes

Clin Cancer Res June 15 2017 23 (12) 3203-3213; DOI:10.1158/1078-0432.CCR-16-1946
Biology of Human Tumors

Absence of Cytomegalovirus in Glioblastoma and Other High-grade Gliomas by Real-time PCR, Immunohistochemistry, and In Situ Hybridization

Matthias Holdhoff, Gunes Guner, Fausto J. Rodriguez, Jessica L. Hicks, Qizhi Zheng, Michael S. Forman, Xiaobu Ye, Stuart A. Grossman, Alan K. Meeker, Christopher M. Heaphy, Charles G. Eberhart, Angelo M. De Marzo and Ravit Arav-Boger

Clin Cancer Res June 15 2017 23 (12) 3150-3157; DOI:10.1158/1078-0432.CCR-16-1490
Biology of Human Tumors | AuthorChoice

Transcriptional Mechanisms of Resistance to Anti–PD-1 Therapy

Maria L. Ascierto, Alvin Makohon-Moore, Evan J. Lipson, Janis M. Taube, Tracee L. McMiller, Alan E. Berger, Jinshui Fan, Genevieve J. Kaunitz, Tricia R. Cottrell, Zachary A. Kohutek, Alexander Favorov, Vladimir Makarov, Nadeem Riaz, Timothy A. Chan, Leslie Cope, Ralph H. Hruban, Drew M. Pardoll, Barry S. Taylor, David B. Solit, Christine A. Iacobuzio-Donahue and Suzanne L. Topalian

Clin Cancer Res June 15 2017 23 (12) 3168-3180; DOI:10.1158/1078-0432.CCR-17-0270

See the Table of Contents

OnlineFirst Articles

First-in-Human Study of AMG 820
Kyriakos P. Papadopoulos, et al.
Diffusion MRI Predicts Response to Anti-VEGF in rGBM
Benjamin M Ellingson, et al.
Ipilimumab as Maintenance Treatment in Gastric or GEJ Cancer
Yung-Jue Bang, et al.
Guide to Clinical Exposures of Anticancer Drugs
Dane R. Liston, Myrtle Davis

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