Clinical Cancer Research, Vol 1, Issue 10 1189-1194, Copyright © 1995 by American Association for Cancer Research

ARTICLES

Prognostic value of amplification of c-erb-B2 in bladder carcinoma

U Lonn, S Lonn, S Friberg, B Nilsson, C Silfversward and B Stenkvist
Radiumhemmet, Department of Cancer Epidemiology, Division of Cytology, Karolinska Hospital, S-171 76 Stockholm, Sweden.

Amplification of c-erb-B2 is examined in patients with transitional cell bladder carcinoma. In a pilot study we found that the amplification correlated with high tumor grade. Tumor grade is a known prognostic factor. Therefore, we next examined the prognostic value of c-erb-B2 amplification in patients with >16 years of clinical follow-up. The gene copy number was determined, using semiquantitative PCR, in archival formalin-fixed tissues. Twenty-three percent (37/163 patients) showed the amplification. The amplification correlated with grade and stage. Moreover, we found that tumor grade (P < 0.001) and c-erb-B2 amplification (P < 0.001) showed prognostic information for survival. Patients with grade 3 tumors and concomitant c-erb-B2 amplification showed the worst prognosis. Multivariate analysis indicates that grade and c-erb-B2 amplification are independent prognostic factors.

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