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Imaging Correlates of Molecular Signatures in Oligodendrogliomas

¹ Departments of Clinical Neurological Sciences, Radiology, and Oncology, University of Western Ontario and London Regional Cancer Centre, London, Ontario, Canada; ² Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts; ³ Departments of Clinical Neurosciences and Oncology, University of Calgary and Tom Baker Cancer Centre, Calgary, Alberta, Canada; and ⁴ Department of Pathology and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts

ABSTRACT

Molecular subsets of oligodendroglioma behave in biologically distinct ways. Their locations in the brain, rates of growth, and responses to therapy differ with their genotypes. Retrospectively, we inquired whether allelic loss of chromosomal arms 1p and 19q, an early molecular event and favorable prognostic marker in oligodendrogliomas, were reflected in their appearance on magnetic resonance imaging. Loss of 1p and 19q was associated with an indistinct border on T₁ images and mixed intensity signal on T₁ and T₂. Loss of 1p and 19q was also associated with paramagnetic susceptibility effect and with calcification, a common histopathological finding in oligodendrogliomas. These data encourage prospective evaluation of molecular alterations and magnetic resonance imaging characteristics of glial neoplasms.

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