Clinical Cancer Research Bridging the Lab and the Clinic in Cancer Medicine Tumor Immunology: New Perspectives
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nielsen, T. O.
Right arrow Articles by Perou, C. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nielsen, T. O.
Right arrow Articles by Perou, C. M.
Clinical Cancer Research Vol. 10, 5367-5374, August 15, 2004
© 2004 American Association for Cancer Research

Molecular Oncology, Markers, Clinical Correlates

Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma

Torsten O. Nielsen1, Forrest D. Hsu1, Kristin Jensen2, Maggie Cheang1, Gamze Karaca4,5, Zhiyuan Hu4,5, Tina Hernandez-Boussard3, Chad Livasy4,6, Dave Cowan4,7, Lynn Dressler4,7, Lars A. Akslen8, Joseph Ragaz9, Allen M. Gown10, C. Blake Gilks1, Matt van de Rijn2 and Charles M. Perou4,5,6

1 Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver Hospital & British Columbia Cancer Agency, Vancouver, British Columbia, Canada; Departments of 2 Pathology and 3 Genetics, Stanford University Medical Center, Stanford, California; 4 Lineberger Comprehensive Cancer Center and Departments of 5 Genetics, 6 Pathology and Laboratory Medicine, and 7 Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; 8 Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway; 9 McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec, Canada; and 10 PhenoPath Laboratories, Seattle, Washington

ABSTRACT

Purpose: Expression profiling studies classified breast carcinomas into estrogen receptor (ER)+/luminal, normal breast-like, HER2 overexpressing, and basal-like groups, with the latter two associated with poor outcomes. Currently, there exist clinical assays that identify ER+/luminal and HER2-overexpressing tumors, and we sought to develop a clinical assay for breast basal-like tumors.

Experimental Design: To identify an immunohistochemical profile for breast basal-like tumors, we collected a series of known basal-like tumors and tested them for protein patterns that are characteristic of this subtype. Next, we examined the significance of these protein patterns using tissue microarrays and evaluated the prognostic significance of these findings.

Results: Using a panel of 21 basal-like tumors, which was determined using gene expression profiles, we saw that this subtype was typically immunohistochemically negative for estrogen receptor and HER2 but positive for basal cytokeratins, HER1, and/or c-KIT. Using breast carcinoma tissue microarrays representing 930 patients with 17.4-year mean follow-up, basal cytokeratin expression was associated with low disease-specific survival. HER1 expression was observed in 54% of cases positive for basal cytokeratins (versus 11% of negative cases) and was associated with poor survival independent of nodal status and size. c-KIT expression was more common in basal-like tumors than in other breast cancers but did not influence prognosis.

Conclusions: A panel of four antibodies (ER, HER1, HER2, and cytokeratin 5/6) can accurately identify basal-like tumors using standard available clinical tools and shows high specificity. These studies show that many basal-like tumors express HER1, which suggests candidate drugs for evaluation in these patients.




This article has been cited by other articles:


Home page
 Am. J. Roentgenol.Home page
A. A. Luck, A. J. Evans, J. J. James, E. A. Rakha, E. C. Paish, A. R. Green, and I. O. Ellis
Breast Carcinoma with Basal Phenotype: Mammographic Findings
Am. J. Roentgenol., August 1, 2008; 191(2): 346 - 351.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. Peppercorn and A. H. Partridge
Breast Cancer in Young Women: A New Color or a Different Shade of Pink?
J. Clin. Oncol., July 10, 2008; 26(20): 3303 - 3305.
[Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
N E Lueck and R A Robinson
High levels of expression of cytokeratin 5 are strongly correlated with poor survival in higher grades of mucoepidermoid carcinoma
J. Clin. Pathol., July 1, 2008; 61(7): 837 - 840.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
F.-C. Bidard, M.-C. Matthieu, P. Chollet, I. Raoefils, C. Abrial, J. Domont, M. Spielmann, S. Delaloge, F. Andre, and F. Penault-Llorca
p53 status and efficacy of primary anthracyclines/alkylating agent-based regimen according to breast cancer molecular classes
Ann. Onc., July 1, 2008; 19(7): 1261 - 1265.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. M. Mulligan, D. Pinnaduwage, S. B. Bull, F. P. O'Malley, and I. L. Andrulis
Prognostic Effect of Basal-Like Breast Cancers Is Time Dependent: Evidence from Tissue Microarray Studies on a Lymph Node-Negative Cohort
Clin. Cancer Res., July 1, 2008; 14(13): 4168 - 4174.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
S. L. Hines, L. A. Vallow, W. W. Tan, R. B. McNeil, E. A. Perez, and A. Jain
Clinical outcomes after a diagnosis of brain metastases in patients with estrogen- and/or human epidermal growth factor receptor 2-positive versus triple-negative breast cancer
Ann. Onc., June 5, 2008; (2008) mdn283v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
R A Walker
Immunohistochemical markers as predictive tools for breast cancer
J. Clin. Pathol., June 1, 2008; 61(6): 689 - 696.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
M. Cristofanilli, P. Morandi, S. Krishnamurthy, J. M. Reuben, B.-N. Lee, D. Francis, D. J. Booser, M. C. Green, B. K. Arun, L. Pusztai, et al.
Imatinib mesylate (Gleevec(R)) in advanced breast cancer-expressing C-Kit or PDGFR-{beta}: clinical activity and biological correlations
Ann. Onc., May 29, 2008; (2008) mdn352v1.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
E. A. Rakha, J. S. Reis-Filho, and I. O. Ellis
Basal-Like Breast Cancer: A Critical Review
J. Clin. Oncol., May 20, 2008; 26(15): 2568 - 2581.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
P. L. Nguyen, A. G. Taghian, M. S. Katz, A. Niemierko, R. F. Abi Raad, W. L. Boon, J. R. Bellon, J. S. Wong, B. L. Smith, and J. R. Harris
Breast Cancer Subtype Approximated by Estrogen Receptor, Progesterone Receptor, and HER-2 Is Associated With Local and Distant Recurrence After Breast-Conserving Therapy
J. Clin. Oncol., May 10, 2008; 26(14): 2373 - 2378.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
B Mahler-Araujo, K Savage, S Parry, and J S Reis-Filho
Reduction of E-cadherin expression is associated with non-lobular breast carcinomas of basal-like and triple negative phenotype
J. Clin. Pathol., May 1, 2008; 61(5): 615 - 620.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
E Korsching, S S Jeffrey, W Meinerz, T Decker, W Boecker, and H Buerger
Basal carcinoma of the breast revisited: an old entity with new interpretations
J. Clin. Pathol., May 1, 2008; 61(5): 553 - 560.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
J. S. Ross, C. Hatzis, W. F. Symmans, L. Pusztai, and G. N. Hortobagyi
Commercialized Multigene Predictors of Clinical Outcome for Breast Cancer
Oncologist, May 1, 2008; 13(5): 477 - 493.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Dourdin, B. Schade, R. Lesurf, M. Hallett, R. J. Munn, R. D. Cardiff, and W. J. Muller
Phosphatase and Tensin Homologue Deleted on Chromosome 10 Deficiency Accelerates Tumor Induction in a Mouse Model of ErbB-2 Mammary Tumorigenesis
Cancer Res., April 1, 2008; 68(7): 2122 - 2131.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
J. A. Gilbert, M. P. Goetz, C. A. Reynolds, J. N. Ingle, K. F. Giordano, V. J. Suman, H. E. Blair, R. B. Jenkins, W. L. Lingle, M. M. Reinholz, et al.
Molecular analysis of metaplastic breast carcinoma: high EGFR copy number via aneusomy
Mol. Cancer Ther., April 1, 2008; 7(4): 944 - 951.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
Y. Eralp, D. Derin, Y. Ozluk, E. Yavuz, N. Guney, P. Saip, M. Muslumanoglu, A. Igci, S. Kucucuk, M. Dincer, et al.
MAPK overexpression is associated with anthracycline resistance and increased risk for recurrence in patients with triple-negative breast cancer
Ann. Onc., April 1, 2008; 19(4): 669 - 674.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. M. Wu, M. J. Fackler, M. K. Halushka, D. W. Molavi, M. E. Taylor, W. W. Teo, C. Griffin, J. Fetting, N. E. Davidson, A. M. De Marzo, et al.
Heterogeneity of Breast Cancer Metastases: Comparison of Therapeutic Target Expression and Promoter Methylation Between Primary Tumors and Their Multifocal Metastases
Clin. Cancer Res., April 1, 2008; 14(7): 1938 - 1946.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Vincent-Salomon, C. Lucchesi, N. Gruel, V. Raynal, G. Pierron, R. Goudefroye, F. Reyal, F. Radvanyi, R. Salmon, J.-P. Thiery, et al.
Integrated Genomic and Transcriptomic Analysis of Ductal Carcinoma In situ of the Breast
Clin. Cancer Res., April 1, 2008; 14(7): 1956 - 1965.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
M. Colleoni, G. Viale, D. Zahrieh, L. Bottiglieri, R. D. Gelber, P. Veronesi, A. Balduzzi, R. Torrisi, A. Luini, M. Intra, et al.
Expression of ER, PgR, HER1, HER2, and response: a study of preoperative chemotherapy
Ann. Onc., March 1, 2008; 19(3): 465 - 472.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. C.U. Cheang, D. Voduc, C. Bajdik, S. Leung, S. McKinney, S. K. Chia, C. M. Perou, and T. O. Nielsen
Basal-Like Breast Cancer Defined by Five Biomarkers Has Superior Prognostic Value than Triple-Negative Phenotype
Clin. Cancer Res., March 1, 2008; 14(5): 1368 - 1376.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
M A Thorat, C Marchio, A Morimiya, K Savage, H Nakshatri, J S Reis-Filho, and S Badve
Forkhead box A1 expression in breast cancer is associated with luminal subtype and good prognosis
J. Clin. Pathol., March 1, 2008; 61(3): 327 - 332.
[Abstract] [Full Text] [PDF]

Home page
 Bioscience HorizonsHome page
J. Winter
Morphological and immunophenotypic analysis of basal-like carcinoma of the breast
Bioscience Horizons, March 1, 2008; 1(1): 19 - 27.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Sarrio, S. M. Rodriguez-Pinilla, D. Hardisson, A. Cano, G. Moreno-Bueno, and J. Palacios
Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype
Cancer Res., February 15, 2008; 68(4): 989 - 997.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Ocana and A. Pandiella
Identifying Breast Cancer Druggable Oncogenic Alterations: Lessons Learned and Future Targeted Options
Clin. Cancer Res., February 15, 2008; 14(4): 961 - 970.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Lu, K. Simin, A. Khan, and A. M. Mercurio
Analysis of Integrin {beta}4 Expression in Human Breast Cancer: Association with Basal-like Tumors and Prognostic Significance
Clin. Cancer Res., February 15, 2008; 14(4): 1050 - 1058.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. C. Wolff, D. Berry, L. A. Carey, M. Colleoni, M. Dowsett, M. Ellis, J. E. Garber, D. Mankoff, S. Paik, L. Pusztai, et al.
Research Issues Affecting Preoperative Systemic Therapy for Operable Breast Cancer
J. Clin. Oncol., February 10, 2008; 26(5): 806 - 813.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
C. Klijn, H. Holstege, J. de Ridder, X. Liu, M. Reinders, J. Jonkers, and L. Wessels
Identification of cancer genes using a statistical framework for multiexperiment analysis of nondiscretized array CGH data
Nucleic Acids Res., February 2, 2008; 36(2): e13 - e13.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
F. Andre, R. Nahta, R. Conforti, T. Boulet, M. Aziz, L. X. H. Yuan, F. Meslin, M. Spielmann, G. Tomasic, L. Pusztai, et al.
Expression patterns and predictive value of phosphorylated AKT in early-stage breast cancer
Ann. Onc., February 1, 2008; 19(2): 315 - 320.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. C. Allred, Y. Wu, S. Mao, I. D. Nagtegaal, S. Lee, C. M. Perou, S. K. Mohsin, P. O'Connell, A. Tsimelzon, and D. Medina
Ductal Carcinoma In situ and the Emergence of Diversity during Breast Cancer Evolution
Clin. Cancer Res., January 15, 2008; 14(2): 370 - 378.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Rakha, I. Ellis, and J. Reis-Filho
Are Triple-Negative and Basal-Like Breast Cancer Synonymous?
Clin. Cancer Res., January 15, 2008; 14(2): 618 - 618.
[Full Text] [PDF]

Home page
 Am Soc Clin Oncol Ed BookHome page
E. J. Wasserman and A. R. Tan
Evolving Strategies for the Treatment of "Triple-Negative" Breast Cancer
ASCO Educational Book, January 1, 2008; 2008(1): 120 - 126.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Esseghir, S. K. Todd, T. Hunt, R. Poulsom, I. Plaza-Menacho, J. S. Reis-Filho, and C. M. Isacke
A Role for Glial Cell Derived Neurotrophic Factor Induced Expression by Inflammatory Cytokines and RET/GFR{alpha}1 Receptor Up-regulation in Breast Cancer
Cancer Res., December 15, 2007; 67(24): 11732 - 11741.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
L Da Silva, C Clarke, and S R Lakhani
Demystifying basal-like breast carcinomas
J. Clin. Pathol., December 1, 2007; 60(12): 1328 - 1332.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
L. Harris, H. Fritsche, R. Mennel, L. Norton, P. Ravdin, S. Taube, M. R. Somerfield, D. F. Hayes, and R. C. Bast Jr
American Society of Clinical Oncology 2007 Update of Recommendations for the Use of Tumor Markers in Breast Cancer
J. Clin. Oncol., November 20, 2007; 25(33): 5287 - 5312.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Wienke, G. C. Davies, D. A. Johnson, J. Sturge, M. B.K. Lambros, K. Savage, S. E. Elsheikh, A. R. Green, I. O. Ellis, D. Robertson, et al.
The Collagen Receptor Endo180 (CD280) Is Expressed on Basal-like Breast Tumor Cells and Promotes Tumor Growth In vivo
Cancer Res., November 1, 2007; 67(21): 10230 - 10240.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
C. U. Ihemelandu, L. D. Leffall Jr., R. L. Dewitty, T. J. Naab, H. M. Mezghebe, K. H. Makambi, L. Adams-Campbell, and W. A. Frederick
Molecular Breast Cancer Subtypes in Premenopausal African-American Women, Tumor Biologic Factors and Clinical Outcome
Ann. Surg. Oncol., October 1, 2007; 14(10): 2994 - 3003.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
R Conforti, T Boulet, G Tomasic, E Taranchon, R Arriagada, M Spielmann, M Ducourtieux, J. Soria, T Tursz, S Delaloge, et al.
Breast cancer molecular subclassification and estrogen receptor expression to predict efficacy of adjuvant anthracyclines-based chemotherapy: a biomarker study from two randomized trials
Ann. Onc., September 1, 2007; 18(9): 1477 - 1483.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
S. M. Rodriguez-Pinilla, D. Sarrio, E. Honrado, G. Moreno-Bueno, D. Hardisson, F. Calero, J. Benitez, and J. Palacios
Vimentin and laminin expression is associated with basal-like phenotype in both sporadic and BRCA1-associated breast carcinomas
J. Clin. Pathol., September 1, 2007; 60(9): 1006 - 1012.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
S M. Rodriguez-Pinilla, R. L Jones, M. B K Lambros, E. Arriola, K. Savage, M. James, S. E Pinder, and J. S Reis-Filho
MYC amplification in breast cancer: a chromogenic in situ hybridisation study
J. Clin. Pathol., September 1, 2007; 60(9): 1017 - 1023.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. Dent, M. Trudeau, K. I. Pritchard, W. M. Hanna, H. K. Kahn, C. A. Sawka, L. A. Lickley, E. Rawlinson, P. Sun, and S. A. Narod
Triple-Negative Breast Cancer: Clinical Features and Patterns of Recurrence
Clin. Cancer Res., August 1, 2007; 13(15): 4429 - 4434.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. R. Pollack
A Perspective on DNA Microarrays in Pathology Research and Practice
Am. J. Pathol., August 1, 2007; 171(2): 375 - 385.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Verlinden, I. Vanden Bempt, G. Eelen, M. Drijkoningen, I. Verlinden, K. Marchal, C. De Wolf-Peeters, M.-R. Christiaens, L. Michiels, R. Bouillon, et al.
The E2F-Regulated Gene Chk1 Is Highly Expressed in Triple-Negative Estrogen Receptor /Progesterone Receptor /HER-2 Breast Carcinomas
Cancer Res., July 15, 2007; 67(14): 6574 - 6581.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
S. Singh, Q. Shi, S. T. Bailey, M. J. Palczewski, A. B. Pardee, J. D. Iglehart, and D. K. Biswas
Nuclear factor-{kappa}B activation: a molecular therapeutic target for estrogen receptor-negative and epidermal growth factor receptor family receptor-positive human breast cancer
Mol. Cancer Ther., July 1, 2007; 6(7): 1973 - 1982.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Esseghir, A. Kennedy, P. Seedhar, A. Nerurkar, R. Poulsom, J. S. Reis-Filho, and C. M. Isacke
Identification of NTN4, TRA1, and STC2 as Prognostic Markers in Breast Cancer in a Screen for Signal Sequence Encoding Proteins
Clin. Cancer Res., June 1, 2007; 13(11): 3164 - 3173.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. A. Carey, E. C. Dees, L. Sawyer, L. Gatti, D. T. Moore, F. Collichio, D. W. Ollila, C. I. Sartor, M. L. Graham, and C. M. Perou
The Triple Negative Paradox: Primary Tumor Chemosensitivity of Breast Cancer Subtypes
Clin. Cancer Res., April 15, 2007; 13(8): 2329 - 2334.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
X. R. Yang, M. E. Sherman, D. L. Rimm, J. Lissowska, L. A. Brinton, B. Peplonska, S. M. Hewitt, W. F. Anderson, N. Szeszenia-Dabrowska, A. Bardin-Mikolajczak, et al.
Differences in Risk Factors for Breast Cancer Molecular Subtypes in a Population-Based Study
Cancer Epidemiol. Biomarkers Prev., March 1, 2007; 16(3): 439 - 443.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
E. P. Moiseeva, R. Heukers, and M. M. Manson
EGFR and Src are involved in indole-3-carbinol-induced death and cell cycle arrest of human breast cancer cells
Carcinogenesis, February 1, 2007; 28(2): 435 - 445.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
C. R. James, J. E. Quinn, P. B. Mullan, P. G. Johnston, and D. P. Harkin
BRCA1, a Potential Predictive Biomarker in the Treatment of Breast Cancer
Oncologist, February 1, 2007; 12(2): 142 - 150.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. Castiglioni, M. Terenziani, M. L. Carcangiu, R. Miliano, P. Aiello, L. Bertola, T. Triulzi, P. Gasparini, T. Camerini, G. Sozzi, et al.
Radiation Effects on Development of HER2-Positive Breast Carcinomas
Clin. Cancer Res., January 1, 2007; 13(1): 46 - 51.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Savage, M. B.K. Lambros, D. Robertson, R. L. Jones, C. Jones, A. Mackay, M. James, J. L. Hornick, E. M. Pereira, F. Milanezi, et al.
Caveolin 1 Is Overexpressed and Amplified in a Subset of Basal-like and Metaplastic Breast Carcinomas: A Morphologic, Ultrastructural, Immunohistochemical, and In situ Hybridization Analysis
Clin. Cancer Res., January 1, 2007; 13(1): 90 - 101.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
B. G. Haffty, Q. Yang, M. Reiss, T. Kearney, S. A. Higgins, J. Weidhaas, L. Harris, W. Hait, and D. Toppmeyer
Locoregional Relapse and Distant Metastasis in Conservatively Managed Triple Negative Early-Stage Breast Cancer
J. Clin. Oncol., December 20, 2006; 24(36): 5652 - 5657.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
M. Lacroix
Significance, detection and markers of disseminated breast cancer cells
Endocr. Relat. Cancer, December 1, 2006; 13(4): 1033 - 1067.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
E. K. Lobenhofer, G. A. Boorman, K. L. Phillips, A. N. Heinloth, D. E. Malarkey, P. E. Blackshear, C. Houle, and P. Hurban
Application of Visualization Tools to the Analysis of Histopathological Data Enhances Biological Insight and Interpretation
Toxicol Pathol, December 1, 2006; 34(7): 921 - 928.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Dolled-Filhart, L. Ryden, M. Cregger, K. Jirstrom, M. Harigopal, R. L. Camp, and D. L. Rimm
Classification of breast cancer using genetic algorithms and tissue microarrays.
Clin. Cancer Res., November 1, 2006; 12(21): 6459 - 6468.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
F. Bertucci, D. Birnbaum, and A. Goncalves
Proteomics of Breast Cancer: Principles and Potential Clinical Applications
Mol. Cell. Proteomics, October 1, 2006; 5(10): 1772 - 1786.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
L. Dal Lago, V. Durbecq, C. Desmedt, R. Salgado, T. Verjat, L. Lespagnard, Y. Ma, I. Veys, A. Di Leo, C. Sotiriou, et al.
Correction for chromosome-17 is critical for the determination of true Her-2/neu gene amplification status in breast cancer.
Mol. Cancer Ther., October 1, 2006; 5(10): 2572 - 2579.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Amend, D. Hicks, and C. B. Ambrosone
Breast Cancer in African-American Women: Differences in Tumor Biology from European-American Women.
Cancer Res., September 1, 2006; 66(17): 8327 - 8330.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Y. Nakamura, S. Suzuki, T. Suzuki, K. Ono, I. Miura, F. Satoh, T. Moriya, H. Saito, S. Yamada, S. Ito, et al.