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Proceedings of the First International Conference |
1 Laboratory of Cancer Genetics, and 2 Bioinformatics Special Program, Van Andel Research Institute, Grand Rapids, Michigan; 3 The Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland; 4 Metropolitan Hospital, Grand Rapids, Michigan; 5 Division of Surgical Pathology, Northwestern University, Chicago, Illinois; 6 Department of Medicine, Alexandra Hospital, Republic of Singapore; and 7 Department of Urology, Michigan State University, Lansing, Michigan
Renal cell carcinoma (RCC) is a histologically diverse disease, with variable and often unpredictable clinical behavior. The prognosis worsens dramatically with the onset of clinical metastasis, and current regimens of systemic therapy yield only modest benefits for metastatic RCC. Gene expression profiling is a promising technique for refining the diagnosis and staging of RCC, as well as for highlighting potential therapeutic targets. We review the recent advances in expression profiling of RCC and discuss the clinical and biological insights obtained from these studies.
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