This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hines-Peralta, A. Articles by Goldberg, S. N. Search for Related Content PubMed PubMed Citation Articles by Hines-Peralta, A. Articles by Goldberg, S. N.

Review of Radiofrequency Ablation for Renal Cell Carcinoma

Minimally Invasive Tumor Therapy Laboratory, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts

This review will discuss how minimally invasive, image-guided radiofrequency (RF) tumor ablation [i.e., coagulating tumor using short-duration heating (<15 minutes) by directly applying temperatures >50°C via needle electrodes] is being incorporated as a clinical tool for the treatment of renal cell carcinoma. RF ablation has been used to treat focal liver tumors. Potential benefits of this thermal therapy include reduced morbidity and mortality compared with standard surgical resection and the ability to treat nonsurgical patients. More recently, this technique has been introduced to treat focal renal tumors, particularly incidental lesions smaller than 3 cm in elderly patients and those with comorbid conditions. Other uses have included treatment in patients with von Hippel-Lindau syndrome and other diseases that predispose patients to multiple renal carcinomas, where renal parenchymal preservation is desired. Techniques, complications, and results will be discussed. Additionally, strategies that we are currently studying to improve RF outcomes and enable the potential treatment of larger tumors will be addressed. Most notably, recent data on increased coagulation achieved by combining RF ablation with antivascular/antiangiogenic therapies, such as arsenic trioxide, that reduce blood flow and promote heat retention are provided.

This article has been cited by other articles:

				A. Hakime, A. Hines-Peralta, H. Peddi, M. B. Atkins, V. P. Sukhatme, S. Signoretti, M. Regan, and S. N. Goldberg Combination of Radiofrequency Ablation with Antiangiogenic Therapy for Tumor Ablation Efficacy: Study in Mice Radiology, August 1, 2007; 244(2): 464 - 470. [Abstract] [Full Text] [PDF]

				S. A. Solazzo, M. Ahmed, Z. Liu, A. U. Hines-Peralta, and S. N. Goldberg High-Power Generator for Radiofrequency Ablation: Larger Electrodes and Pulsing Algorithms in Bovine ex Vivo and Porcine in Vivo Settings Radiology, March 1, 2007; 242(3): 743 - 750. [Abstract] [Full Text] [PDF]

				A. Hines-Peralta, V. Sukhatme, M. Regan, S. Signoretti, Z.-j. Liu, and S. N. Goldberg Improved Tumor Destruction with Arsenic Trioxide and Radiofrequency Ablation in Three Animal Models Radiology, July 1, 2006; 240(1): 82 - 89. [Abstract] [Full Text] [PDF]

				A. U. Hines-Peralta, N. Pirani, P. Clegg, N. Cronin, T. P. Ryan, Z. Liu, and S. N. Goldberg Microwave Ablation: Results with a 2.45-GHz Applicator in ex Vivo Bovine and in Vivo Porcine Liver Radiology, April 1, 2006; 239(1): 94 - 102. [Abstract] [Full Text] [PDF]