Clinical Cancer Research Targets AACR Membership
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jeng, Y.-M.
Right arrow Articles by Hsu, H.-C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jeng, Y.-M.
Right arrow Articles by Hsu, H.-C.
Clinical Cancer Research Vol. 10, 2065-2071, March 2004
© 2004 American Association for Cancer Research

Molecular Oncology, Markers, Clinical Correlates

Overexpression and Amplification of Aurora-A in Hepatocellular Carcinoma

Yung-Ming Jeng1,2, Shian-Yang Peng4, Chiao-Ying Lin3 and Hey-Chi Hsu1,2

1 Department of Pathology, National Taiwan University Hospital; 2 Graduate Institute of Pathology and 3 Clinical Dentistry, College of Medicine, National Taiwan University; and 4 Department of General Education, National Taipei College of Nursing, Taipei, Taiwan

Purpose: Aurora-A/STK15/BTAK, a centrosome-associated serine/threonine kinase, has been shown to induce chromosomal instability, leading to aneuploidy and cell transformation. The purpose of this study was to investigate the expression and amplification of Aurora-A in hepatocellular carcinoma (HCC).

Experimental Design: Aurora-A mRNA levels were measured in 224 HCCs and 199 paired nontumorous liver tissues by reverse transcription-PCR. Aurora-A mRNA and protein levels of 8 were also measured by reverse transcription-PCR and Western blot hybridization in 8 liver cancer cell lines. Amplification of Aurora-A was determined by Southern blot hybridization in 99 cases.

Results: Aurora-A was overexpressed in 137 of 224 (61%) HCCs and all 8 of the cell lines. Overexpression of Aurora-A was associated with high-grade (grade II-IV), and high-stage (stage IIIB-IV) tumors, p53 mutation, infrequent ß-catenin mutation, and poor outcome. Aurora-A overexpression and p53 mutation acted synergistically toward poor prognosis. Amplification of Aurora-A was detected only in 3 HCCs.

Conclusion: The results show that Aurora-A is overexpressed frequently in HCC, and correlated with high grade and high stage, indicating that overexpression of Aurora-A plays a role in the development and progression of HCC.




This article has been cited by other articles:


Home page
 Mol Cancer ResHome page
C.-C. Li, H.-Y. Chu, C.-W. Yang, C.-K. Chou, and T.-F. Tsai
Aurora-A Overexpression in Mouse Liver Causes p53-Dependent Premitotic Arrest during Liver Regeneration
Mol. Cancer Res., May 1, 2009; 7(5): 678 - 688.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
E. C. VanderPorten, P. Taverna, J. N. Hogan, M. D. Ballinger, W. M. Flanagan, and R. V. Fucini
The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model
Mol. Cancer Ther., April 1, 2009; 8(4): 930 - 939.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. J. Perugorria, J. Castillo, M. U. Latasa, S. Goni, V. Segura, B. Sangro, J. Prieto, M. A. Avila, and C. Berasain
Wilms' Tumor 1 Gene Expression in Hepatocellular Carcinoma Promotes Cell Dedifferentiation and Resistance to Chemotherapy
Cancer Res., February 15, 2009; 69(4): 1358 - 1367.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
Y.-C. Shen, F.-C. Hu, Y.-M. Jeng, Y.-T. Chang, Z.-Z. Lin, M.-C. Chang, C. Hsu, and A.-L. Cheng
Nuclear Overexpression of Mitotic Regulatory Proteins in Biliary Tract Cancer: Correlation with Clinicopathologic Features and Patient Survival
Cancer Epidemiol. Biomarkers Prev., February 1, 2009; 18(2): 417 - 423.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
K. Wakahara, T. Ohno, M. Kimura, T. Masuda, S. Nozawa, T. Dohjima, T. Yamamoto, A. Nagano, G. Kawai, A. Matsuhashi, et al.
EWS-Fli1 Up-Regulates Expression of the Aurora A and Aurora B Kinases
Mol. Cancer Res., December 1, 2008; 6(12): 1937 - 1945.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C.-Y. Ko, H.-C. Hsu, M.-R. Shen, W.-C. Chang, and J.-M. Wang
Epigenetic Silencing of CCAAT/Enhancer-binding Protein {delta} Activity by YY1/Polycomb Group/DNA Methyltransferase Complex
J. Biol. Chem., November 7, 2008; 283(45): 30919 - 30932.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
A. Klein, D. Flugel, and T. Kietzmann
Transcriptional Regulation of Serine/Threonine Kinase-15 (STK15) Expression by Hypoxia and HIF-1
Mol. Biol. Cell, September 1, 2008; 19(9): 3667 - 3675.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
O. Gautschi, J. Heighway, P. C. Mack, P. R. Purnell, P. N. Lara Jr., and D. R. Gandara
Aurora Kinases as Anticancer Drug Targets
Clin. Cancer Res., March 15, 2008; 14(6): 1639 - 1648.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
E. Ogawa, K. Takenaka, H. Katakura, M. Adachi, Y. Otake, Y. Toda, H. Kotani, T. Manabe, H. Wada, and F. Tanaka
Perimembrane Aurora-A Expression is a Significant Prognostic Factor in Correlation with Proliferative Activity in Non-Small-Cell Lung Cancer (NSCLC)
Ann. Surg. Oncol., February 1, 2008; 15(2): 547 - 554.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
P. Carpinelli, R. Ceruti, M. L. Giorgini, P. Cappella, L. Gianellini, V. Croci, A. Degrassi, G. Texido, M. Rocchetti, P. Vianello, et al.
PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer
Mol. Cancer Ther., December 1, 2007; 6(12): 3158 - 3168.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. A. Kulkarni, M. Loddo, E. Leo, M. Rashid, K. L. Eward, T. R. Fanshawe, J. Butcher, A. Frost, J. A. Ledermann, G. H. Williams, et al.
DNA Replication Licensing Factors and Aurora Kinases are Linked to Aneuploidy and Clinical Outcome in Epithelial Ovarian Carcinoma
Clin. Cancer Res., October 15, 2007; 13(20): 6153 - 6161.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. N. Landen Jr., Y. G. Lin, A. Immaneni, M. T. Deavers, W. M. Merritt, W. A. Spannuth, D. C. Bodurka, D. M. Gershenson, W. R. Brinkley, and A. K. Sood
Overexpression of the Centrosomal Protein Aurora-A Kinase is Associated with Poor Prognosis in Epithelial Ovarian Cancer Patients
Clin. Cancer Res., July 15, 2007; 13(14): 4098 - 4104.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
W.-H. Su, C.-C. Chao, S.-H. Yeh, D.-S. Chen, P.-J. Chen, and Y.-S. Jou
OncoDB.HCC: an integrated oncogenomic database of hepatocellular carcinoma revealed aberrant cancer target genes and loci
Nucleic Acids Res., January 12, 2007; 35(suppl_1): D727 - D731.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. Reiter, P. Gais, U. Jutting, M. K. Steuer-Vogt, A. Pickhard, K. Bink, S. Rauser, S. Lassmann, H. Hofler, M. Werner, et al.
Aurora Kinase A Messenger RNA Overexpression Is Correlated with Tumor Progression and Shortened Survival in Head and Neck Squamous Cell Carcinoma
Clin. Cancer Res., September 1, 2006; 12(17): 5136 - 5141.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
Y.-C. Hsu, H.-H. Fu, Y.-M. Jeng, P.-H. Lee, and S.-D. Yang
Proline-Directed Protein Kinase FA Is a Powerful and Independent Prognostic Predictor for Progression and Patient Survival of Hepatocellular Carcinoma
J. Clin. Oncol., August 10, 2006; 24(23): 3780 - 3788.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. Soncini, P. Carpinelli, L. Gianellini, D. Fancelli, P. Vianello, L. Rusconi, P. Storici, P. Zugnoni, E. Pesenti, V. Croci, et al.
PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity.
Clin. Cancer Res., July 1, 2006; 12(13): 4080 - 4089.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Lopez-Rios, S. Chuai, R. Flores, S. Shimizu, T. Ohno, K. Wakahara, P. B. Illei, S. Hussain, L. Krug, M. F. Zakowski, et al.
Global Gene Expression Profiling of Pleural Mesotheliomas: Overexpression of Aurora Kinases and P16/CDKN2A Deletion as Prognostic Factors and Critical Evaluation of Microarray-Based Prognostic Prediction.
Cancer Res., March 15, 2006; 66(6): 2970 - 2979.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
K. Yamashita, H. Igarashi, Y. Kitayama, T. Ozawa, S. Kiyose, H. Konno, T. Kazui, S. Ishikawa, H. Aburatani, F. Tanioka, et al.
Chromosomal Numerical Abnormality Profiles of Gastrointestinal Stromal Tumors
Jpn. J. Clin. Oncol., February 1, 2006; 36(2): 85 - 92.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Hata, T. Furukawa, M. Sunamura, S. Egawa, F. Motoi, N. Ohmura, T. Marumoto, H. Saya, and A. Horii
RNA Interference Targeting Aurora Kinase A Suppresses Tumor Growth and Enhances the Taxane Chemosensitivity in Human Pancreatic Cancer Cells
Cancer Res., April 1, 2005; 65(7): 2899 - 2905.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Tong, Y. Zhong, J. Kong, L. Dong, Y. Song, M. Fu, Z. Liu, M. Wang, L. Guo, S. Lu, et al.
Overexpression of Aurora-A Contributes to Malignant Development of Human Esophageal Squamous Cell Carcinoma
Clin. Cancer Res., November 1, 2004; 10(21): 7304 - 7310.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2004 by the American Association for Cancer Research.