This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Madjd, Z. Articles by Pinder, S. E. Search for Related Content PubMed PubMed Citation Articles by Madjd, Z. Articles by Pinder, S. E.

Loss of CD55 Is Associated with Aggressive Breast Tumors

¹ Cancer Research UK Academic Unit of Clinical Oncology, and ² Division of Histopathology, University of Nottingham, City Hospital, Nottingham, United Kingdom

Purpose: CD55 is a complement regulatory protein expressed by cells to protect them from bystander attack by complement. CD55 is overexpressed on some tumor cell lines, and in colorectal carcinomas, it has been shown to be an indicator of poor prognostic.

Experimental Design: A large set of samples (480) from patients with primary operable breast cancer followed for 4–192 months were included in the present study. The prognostic significance of CD55 was then investigated in these tumors using an anti-CD55 monoclonal antibody (RM1) that we raised against a synthetic peptide and a standard immunohistochemistry method.

Results: Ninety-five percent of the breast carcinomas expressed CD55 (RM1) with intensity ranging from weak (51%) to strong (6%). High expression of CD55 was significantly associated with low-grade (grades 1 or 2; P = 0.001), lymph node negativity (P = 0.031), and good prognosis tumors (Nottingham Prognostic Index < 3.4; P < 0.001). Survival analysis showed CD55 overexpression was associated with a more favorable outcome and loss of CD55 being associated with poor survival (P = 0.001). Intensity of CD55 expression was significantly correlated (P = 0.002) with intensity of CD59 expression (as shown in a previous study) in these series of patients.

Conclusions: In conclusion, we found that loss of both CD55 and CD59 in breast carcinomas is associated with a worse prognosis.

This article has been cited by other articles:

				J.-i. Ikeda, E. Morii, Y. Liu, Y. Qiu, N. Nakamichi, R. Jokoji, Y. Miyoshi, S. Noguchi, and K. Aozasa Prognostic Significance of CD55 Expression in Breast Cancer Clin. Cancer Res., August 1, 2008; 14(15): 4780 - 4786. [Abstract] [Full Text] [PDF]

				P. Rolland, Z. Madjd, L. Durrant, I. O Ellis, R. Layfield, and I. Spendlove The ubiquitin-binding protein p62 is expressed in breast cancers showing features of aggressive disease Endocr. Relat. Cancer, March 1, 2007; 14(1): 73 - 80. [Abstract] [Full Text] [PDF]