Clinical Cancer Research CTRC-AACR San Antonio Breast Cancer Symposium Translational Cancer Medicine 2008: Cancer Clinical Trials and Personalized Medicine
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Data
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rouzier, R.
Right arrow Articles by Pusztai, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rouzier, R.
Right arrow Articles by Pusztai, L.
Clinical Cancer Research Vol. 11, 5678-5685, August 15, 2005
© 2005 American Association for Cancer Research

Human Cancer Biology

Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy

Roman Rouzier1,4, Charles M. Perou5, W. Fraser Symmans2, Nuhad Ibrahim1, Massimo Cristofanilli1, Keith Anderson3, Kenneth R. Hess3, James Stec6,7, Mark Ayers6, Peter Wagner1, Paolo Morandi1, Chang Fan5, Islam Rabiul1, Jeffrey S. Ross6, Gabriel N. Hortobagyi1 and Lajos Pusztai1

Authors' Affiliations: Departments of 1 Breast Medical Oncology, 2 Pathology, and 3 Biostatistics and Applied Mathematics, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 4 Unité Propre de l'Enseignement Supérieur EA 3535, Institut Gustave Roussy, Villejuif, France; 5 Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina; 6 Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts; and 7 Albany Medical College, Albany, New York

Requests for reprints: Lajos Pusztai, Department of Breast Medical Oncology, University of Texas M.D. Anderson Cancer Center, Unit 424, 1515 Holcombe Boulevard, Houston, TX 77030-4009. Phone: 713-792-2817; Fax: 713-794-4385; E-mail: lpusztai{at}mdanderson.org.

Purpose: Molecular classification of breast cancer has been proposed based on gene expression profiles of human tumors. Luminal, basal-like, normal-like, and erbB2+ subgroups were identified and were shown to have different prognoses. The goal of this research was to determine if these different molecular subtypes of breast cancer also respond differently to preoperative chemotherapy.

Experimental Design: Fine needle aspirations of 82 breast cancers were obtained before starting preoperative paclitaxel followed by 5-fluorouracil, doxorubicin, and cyclophosphamide chemotherapy. Gene expression profiling was done with Affymetrix U133A microarrays and the previously reported "breast intrinsic" gene set was used for hierarchical clustering and multidimensional scaling to assign molecular class.

Results: The basal-like and erbB2+ subgroups were associated with the highest rates of pathologic complete response (CR), 45% [95% confidence interval (95% CI), 24-68] and 45% (95% CI, 23-68), respectively, whereas the luminal tumors had a pathologic CR rate of 6% (95% CI, 1-21). No pathologic CR was observed among the normal-like cancers (95% CI, 0-31). Molecular class was not independent of conventional cliniocopathologic predictors of response such as estrogen receptor status and nuclear grade. None of the 61 genes associated with pathologic CR in the basal-like group were associated with pathologic CR in the erbB2+ group, suggesting that the molecular mechanisms of chemotherapy sensitivity may vary between these two estrogen receptor–negative subtypes.

Conclusions: The basal-like and erbB2+ subtypes of breast cancer are more sensitive to paclitaxel- and doxorubicin-containing preoperative chemotherapy than the luminal and normal-like cancers.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
C. O'Brien, G. Cavet, A. Pandita, X. Hu, L. Haydu, S. Mohan, K. Toy, C. S. Rivers, Z. Modrusan, L. C. Amler, et al.
Functional Genomics Identifies ABCC3 as a Mediator of Taxane Resistance in HER2-Amplified Breast Cancer
Cancer Res., July 1, 2008; 68(13): 5380 - 5389.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Schmidt, D. Bohm, C. von Torne, E. Steiner, A. Puhl, H. Pilch, H.-A. Lehr, J. G. Hengstler, H. Kolbl, and M. Gehrmann
The Humoral Immune System Has a Key Prognostic Impact in Node-Negative Breast Cancer
Cancer Res., July 1, 2008; 68(13): 5405 - 5413.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
F.-C. Bidard, M.-C. Matthieu, P. Chollet, I. Raoefils, C. Abrial, J. Domont, M. Spielmann, S. Delaloge, F. Andre, and F. Penault-Llorca
p53 status and efficacy of primary anthracyclines/alkylating agent-based regimen according to breast cancer molecular classes
Ann. Onc., July 1, 2008; 19(7): 1261 - 1265.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
B. Sirohi, M. Arnedos, S. Popat, S. Ashley, A. Nerurkar, G. Walsh, S. Johnston, and I. E. Smith
Platinum-based chemotherapy in triple-negative breast cancer
Ann. Onc., June 20, 2008; (2008) mdn395v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
R A Walker
Immunohistochemical markers as predictive tools for breast cancer
J. Clin. Pathol., June 1, 2008; 61(6): 689 - 696.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
E. A. Rakha, J. S. Reis-Filho, and I. O. Ellis
Basal-Like Breast Cancer: A Critical Review
J. Clin. Oncol., May 20, 2008; 26(15): 2568 - 2581.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Smid, Y. Wang, Y. Zhang, A. M. Sieuwerts, J. Yu, J. G.M. Klijn, J. A. Foekens, and J. W.M. Martens
Subtypes of Breast Cancer Show Preferential Site of Relapse
Cancer Res., May 1, 2008; 68(9): 3108 - 3114.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
O. Gluz, U. A. Nitz, N. Harbeck, E. Ting, R. Kates, A. Herr, W. Lindemann, C. Jackisch, W. E. Berdel, H. Kirchner, et al.
Triple-negative high-risk breast cancer derives particular benefit from dose intensification of adjuvant chemotherapy: results of WSG AM-01 trial
Ann. Onc., May 1, 2008; 19(5): 861 - 870.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
E Korsching, S S Jeffrey, W Meinerz, T Decker, W Boecker, and H Buerger
Basal carcinoma of the breast revisited: an old entity with new interpretations
J. Clin. Pathol., May 1, 2008; 61(5): 553 - 560.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
J. S. Ross, C. Hatzis, W. F. Symmans, L. Pusztai, and G. N. Hortobagyi
Commercialized Multigene Predictors of Clinical Outcome for Breast Cancer
Oncologist, May 1, 2008; 13(5): 477 - 493.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. Puhalla, E. Mrozek, D. Young, S. Ottman, A. McVey, K. Kendra, N. J. Merriman, M. Knapp, T. Patel, M. E. Thompson, et al.
Randomized Phase II Adjuvant Trial of Dose-Dense Docetaxel Before or After Doxorubicin Plus Cyclophosphamide in Axillary Node-Positive Breast Cancer
J. Clin. Oncol., April 1, 2008; 26(10): 1691 - 1697.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
L. Pusztai
Current Status of Prognostic Profiling in Breast Cancer
Oncologist, April 1, 2008; 13(4): 350 - 360.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
H. D. Bear
Measuring Circulating Tumor Cells As a Surrogate End Point for Adjuvant Therapy of Breast Cancer: What Do They Mean and What Should We Do About Them?
J. Clin. Oncol., March 10, 2008; 26(8): 1195 - 1197.
[Full Text] [PDF]

Home page
 Brief Funct Genomic ProteomicHome page
I. G. Yulug and B. Gur-Dedeoglu
Functional genomics in translational cancer research: focus on breast cancer
Brief Funct Genomic Proteomic, March 7, 2008; (2008) eln009v1.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. C.U. Cheang, D. Voduc, C. Bajdik, S. Leung, S. McKinney, S. K. Chia, C. M. Perou, and T. O. Nielsen
Basal-Like Breast Cancer Defined by Five Biomarkers Has Superior Prognostic Value than Triple-Negative Phenotype
Clin. Cancer Res., March 1, 2008; 14(5): 1368 - 1376.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. A. Sparano and S. Paik
Development of the 21-Gene Assay and Its Application in Clinical Practice and Clinical Trials
J. Clin. Oncol., February 10, 2008; 26(5): 721 - 728.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Rakha, I. Ellis, and J. Reis-Filho
Are Triple-Negative and Basal-Like Breast Cancer Synonymous?
Clin. Cancer Res., January 15, 2008; 14(2): 618 - 618.
[Full Text] [PDF]

Home page
 JCOHome page
J. S. Jeruss, E. A. Mittendorf, S. L. Tucker, A. M. Gonzalez-Angulo, T. A. Buchholz, A. A. Sahin, J. N. Cormier, A. U. Buzdar, G. N. Hortobagyi, and K. K. Hunt
Combined Use of Clinical and Pathologic Staging Variables to Define Outcomes for Breast Cancer Patients Treated With Neoadjuvant Therapy
J. Clin. Oncol., January 10, 2008; 26(2): 246 - 252.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
S. Paik, Y. Taniyama, and C. E. Geyer Jr
Anthracyclines in the Treatment of HER2-Negative Breast Cancer
J Natl Cancer Inst, January 2, 2008; 100(1): 2 - 4.
[Full Text] [PDF]

Home page
 Am Soc Clin Oncol Ed BookHome page
E. J. Wasserman and A. R. Tan
Evolving Strategies for the Treatment of "Triple-Negative" Breast Cancer
ASCO Educational Book, January 1, 2008; 2008(1): 120 - 126.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J.-H. Chen, R. S. Mehta, P. M. Carpenter, O. Nalcioglu, and M.-Y. Su
Magnetic Resonance Imaging in Predicting Pathological Response of Triple Negative Breast Cancer Following Neoadjuvant Chemotherapy
J. Clin. Oncol., December 10, 2007; 25(35): 5667 - 5669.
[Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
L Da Silva, C Clarke, and S R Lakhani
Demystifying basal-like breast carcinomas
J. Clin. Pathol., December 1, 2007; 60(12): 1328 - 1332.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
L. Lusa, L. M. McShane, J. F. Reid, L. De Cecco, F. Ambrogi, E. Biganzoli, M. Gariboldi, and M. A. Pierotti
Challenges in Projecting Clustering Results Across Gene Expression Profiling Datasets
J Natl Cancer Inst, November 21, 2007; 99(22): 1715 - 1723.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. Ignatiadis, N. Xenidis, M. Perraki, S. Apostolaki, E. Politaki, M. Kafousi, E. N. Stathopoulos, A. Stathopoulou, E. Lianidou, G. Chlouverakis, et al.
Different Prognostic Value of Cytokeratin-19 mRNA Positive Circulating Tumor Cells According to Estrogen Receptor and HER2 Status in Early-Stage Breast Cancer
J. Clin. Oncol., November 20, 2007; 25(33): 5194 - 5202.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Wienke, G. C. Davies, D. A. Johnson, J. Sturge, M. B.K. Lambros, K. Savage, S. E. Elsheikh, A. R. Green, I. O. Ellis, D. Robertson, et al.
The Collagen Receptor Endo180 (CD280) Is Expressed on Basal-like Breast Tumor Cells and Promotes Tumor Growth In vivo
Cancer Res., November 1, 2007; 67(21): 10230 - 10240.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
D. F. Hayes, A. D. Thor, L. G. Dressler, D. Weaver, S. Edgerton, D. Cowan, G. Broadwater, L. J. Goldstein, S. Martino, J. N. Ingle, et al.
HER2 and Response to Paclitaxel in Node-Positive Breast Cancer
N. Engl. J. Med., October 11, 2007; 357(15): 1496 - 1506.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. D. Minna, L. Girard, and Y. Xie
Tumor mRNA Expression Profiles Predict Responses to Chemotherapy
J. Clin. Oncol., October 1, 2007; 25(28): 4329 - 4336.
[Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
C. U. Ihemelandu, L. D. Leffall Jr., R. L. Dewitty, T. J. Naab, H. M. Mezghebe, K. H. Makambi, L. Adams-Campbell, and W. A. Frederick
Molecular Breast Cancer Subtypes in Premenopausal African-American Women, Tumor Biologic Factors and Clinical Outcome
Ann. Surg. Oncol., October 1, 2007; 14(10): 2994 - 3003.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
R Conforti, T Boulet, G Tomasic, E Taranchon, R Arriagada, M Spielmann, M Ducourtieux, J. Soria, T Tursz, S Delaloge, et al.
Breast cancer molecular subclassification and estrogen receptor expression to predict efficacy of adjuvant anthracyclines-based chemotherapy: a biomarker study from two randomized trials
Ann. Onc., September 1, 2007; 18(9): 1477 - 1483.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
S. M. Rodriguez-Pinilla, D. Sarrio, E. Honrado, G. Moreno-Bueno, D. Hardisson, F. Calero, J. Benitez, and J. Palacios
Vimentin and laminin expression is associated with basal-like phenotype in both sporadic and BRCA1-associated breast carcinomas
J. Clin. Pathol., September 1, 2007; 60(9): 1006 - 1012.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
K. Altundag, D. S Dede, and T. Purnak
Albumin-bound paclitaxel (ABI-007; Abraxane) in the management of basal-like breast carcinoma
J. Clin. Pathol., August 1, 2007; 60(8): 958 - 958.
[Full Text] [PDF]

Home page
 Ann OncolHome page
P. Lonning, S Knappskog, V Staalesen, R Chrisanthar, and J. Lillehaug
Breast cancer prognostication and prediction in the postgenomic era
Ann. Onc., August 1, 2007; 18(8): 1293 - 1306.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
M. F. Burkart, J. D. Wren, J. I. Herschkowitz, C. M. Perou, and H. R. Garner
Clustering microarray-derived gene lists through implicit literature relationships
Bioinformatics, August 1, 2007; 23(15): 1995 - 2003.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Verlinden, I. Vanden Bempt, G. Eelen, M. Drijkoningen, I. Verlinden, K. Marchal, C. De Wolf-Peeters, M.-R. Christiaens, L. Michiels, R. Bouillon, et al.
The E2F-Regulated Gene Chk1 Is Highly Expressed in Triple-Negative Estrogen Receptor /Progesterone Receptor /HER-2 Breast Carcinomas
Cancer Res., July 15, 2007; 67(14): 6574 - 6581.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. Agulnik, G. da Cunha Santos, D. Hedley, T. Nicklee, P. P. dos Reis, J. Ho, G. R. Pond, H. Chen, S. Chen, Y. Shyr, et al.
Predictive and Pharmacodynamic Biomarker Studies in Tumor and Skin Tissue Samples of Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Treated With Erlotinib
J. Clin. Oncol., June 1, 2007; 25(16): 2184 - 2190.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
S. Paik
Development and Clinical Utility of a 21-Gene Recurrence Score Prognostic Assay in Patients with Early Breast Cancer Treated with Tamoxifen
Oncologist, June 1, 2007; 12(6): 631 - 635.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. A. Carey, E. C. Dees, L. Sawyer, L. Gatti, D. T. Moore, F. Collichio, D. W. Ollila, C. I. Sartor, M. L. Graham, and C. M. Perou
The Triple Negative Paradox: Primary Tumor Chemosensitivity of Breast Cancer Subtypes
Clin. Cancer Res., April 15, 2007; 13(8): 2329 - 2334.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
K. Altundag, H. Harputluoglu, S. Aksoy, and I. H. Gullu
Potential Chemotherapy Options in the Triple Negative Subtype of Breast Cancer
J. Clin. Oncol., April 1, 2007; 25(10): 1294 - 1295.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Huang, K. Reeves, X. Han, C. Fairchild, S. Platero, T. W. Wong, F. Lee, P. Shaw, and E. Clark
Identification of Candidate Molecular Markers Predicting Sensitivity in Solid Tumors to Dasatinib: Rationale for Patient Selection
Cancer Res., March 1, 2007; 67(5): 2226 - 2238.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. N. Harris, F. You, S. J. Schnitt, A. Witkiewicz, X. Lu, D. Sgroi, P. D. Ryan, S. E. Come, H. J. Burstein, B.-A. Lesnikoski, et al.
Predictors of Resistance to Preoperative Trastuzumab and Vinorelbine for HER2-Positive Early Breast Cancer
Clin. Cancer Res., February 15, 2007; 13(4): 1198 - 1207.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
C. R. James, J. E. Quinn, P. B. Mullan, P. G. Johnston, and D. P. Harkin
BRCA1, a Potential Predictive Biomarker in the Treatment of Breast Cancer
Oncologist, February 1, 2007; 12(2): 142 - 150.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. Diallo-Danebrock, E. Ting, O. Gluz, A. Herr, S. Mohrmann, H. Geddert, A. Rody, K.-L. Schaefer, S. E. Baldus, A. Hartmann, et al.
Protein Expression Profiling in High-Risk Breast Cancer Patients Treated with High-Dose or Conventional Dose-Dense Chemotherapy
Clin. Cancer Res., January 15, 2007; 13(2): 488 - 497.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
B. G. Haffty, Q. Yang, M. Reiss, T. Kearney, S. A. Higgins, J. Weidhaas, L. Harris, W. Hait, and D. Toppmeyer
Locoregional Relapse and Distant Metastasis in Conservatively Managed Triple Negative Early-Stage Breast Cancer
J. Clin. Oncol., December 20, 2006; 24(36): 5652 - 5657.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
S. K Gruvberger-Saal, H. E Cunliffe, K. M Carr, and I. A Hedenfalk
Microarrays in breast cancer research and clinical practice - the future lies ahead
Endocr. Relat. Cancer, December 1, 2006; 13(4): 1017 - 1031.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
T. Sorlie, C. M. Perou, C. Fan, S. Geisler, T. Aas, A. Nobel, G. Anker, L. A. Akslen, D. Botstein, A.-L. Borresen-Dale, et al.
Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer.
Mol. Cancer Ther., November 1, 2006; 5(11): 2914 - 2918.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
F. Bertucci, D. Birnbaum, and A. Goncalves
Proteomics of Breast Cancer: Principles and Potential Clinical Applications
Mol. Cell. Proteomics, October 1, 2006; 5(10): 1772 - 1786.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
K. R. Hess, K. Anderson, W. F. Symmans, V. Valero, N. Ibrahim, J. A. Mejia, D. Booser, R. L. Theriault, A. U. Buzdar, P. J. Dempsey, et al.
Pharmacogenomic Predictor of Sensitivity to Preoperative Chemotherapy With Paclitaxel and Fluorouracil, Doxorubicin, and Cyclophosphamide in Breast Cancer
J. Clin. Oncol., September 10, 2006; 24(26): 4236 - 4244.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
L. Pusztai, C. Mazouni, K. Anderson, Y. Wu, and W. F. Symmans
Molecular Classification of Breast Cancer: Limitations and Potential
Oncologist, September 1, 2006; 11(8): 868 - 877.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
S Banerjee, J S Reis-Filho, S Ashley, D Steele, A Ashworth, S R Lakhani, and I E Smith
Basal-like breast carcinomas: clinical outcome and response to chemotherapy
J. Clin. Pathol., July 1, 2006; 59(7): 729 - 735.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. E. Hochreiter, H. Xiao, E. M. Goldblatt, S. M. Gryaznov, K. D. Miller, S. Badve, G. W. Sledge, and B.-S. Herbert
Telomerase Template Antagonist GRN163L Disrupts Telomere Maintenance, Tumor Growth, and Metastasis of Breast Cancer.
Clin. Cancer Res., May 15, 2006; 12(10): 3184 - 3192.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
O. Thuerigen, A. Schneeweiss, G. Toedt, P. Warnat, M. Hahn, H. Kramer, B. Brors, C. Rudlowski, A. Benner, F. Schuetz, et al.
Gene Expression Signature Predicting Pathologic Complete Response With Gemcitabine, Epirubicin, and Docetaxel in Primary Breast Cancer
J. Clin. Oncol., April 20, 2006; 24(12): 1839 - 1845.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Anderson, K. R. Hess, M. Kapoor, S. Tirrell, J. Courtemanche, B. Wang, Y. Wu, Y. Gong, G. N. Hortobagyi, W. F. Symmans, et al.
Reproducibility of Gene Expression Signature-Based Predictions in Replicate Experiments
Clin. Cancer Res., March 15, 2006; 12(6): 1721 - 1727.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. M. Rodriguez-Pinilla, D. Sarrio, E. Honrado, D. Hardisson, F. Calero, J. Benitez, and J. Palacios
Prognostic Significance of Basal-Like Phenotype and Fascin Expression in Node-Negative Invasive Breast Carcinomas
Clin. Cancer Res., March 1, 2006; 12(5): 1533 - 1539.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
V. Nygaard and E. Hovig
Options available for profiling small samples: a review of sample amplification technology when combined with microarray profiling
Nucleic Acids Res., February 9, 2006; 34(3): 996 - 1014.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
R. L. Prentice, B. Caan, R. T. Chlebowski, R. Patterson, L. H. Kuller, J. K. Ockene, K. L. Margolis, M. C. Limacher, J. E. Manson, L. M. Parker, et al.
Low-Fat Dietary Pattern and Risk of Invasive Breast Cancer: The Women's Health Initiative Randomized Controlled Dietary Modification Trial
JAMA, February 8, 2006; 295(6): 629 - 642.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. Yuan, Y. Xu, J.-H. Woo, Y. Wang, Y. K. Bae, D.-S. Yoon, R. P. Wersto, E. Tully, K. Wilsbach, and E. Gabrielson
Increased Expression of Mitotic Checkpoint Genes in Breast Cancer Cells with Chromosomal Instability
Clin. Cancer Res., January 15, 2006; 12(2): 405 - 410.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
N. U. Lin, R. Gelman, and E. P. Winer
Dose Density in Breast Cancer: A Simple Message?
J Natl Cancer Inst, December 7, 2005; 97(23): 1712 - 1714.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research