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New Frontiers in Translational Research in Neuro-oncology and the Blood-Brain Barrier: Report of the Tenth Annual Blood-Brain Barrier Disruption Consortium Meeting

¹ Department of Neurology, Oregon Health & Science University, Portland, Oregon; ² Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York; ³ Divisions of Pediatrics and Community Oncology, M.D. Anderson Cancer Center, Houston, Texas; ⁴ Department of Neuro-oncology and Neurosurgery, H. Lee Moffitt Cancer Center, Tampa, Florida; ⁵ Department of Pharmacology, Program in Neurosciences and Physiological Sciences, University of Arizona Medical School, Tucson, Arizona; ⁶ Department of Neurology, Wayne State University, Detroit, Michigan; ⁷ Department of Biochemistry and Molecular Biology, University of Minnesota School of Medicine, Duluth, Minnesota; ⁸ Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota; ⁹ National Cancer Institute, Cancer Imaging Program, Bethesda, Maryland; ¹⁰ Department of Hematology, Oncology, and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany; ¹¹ Department of Neurosurgery, Massachusetts General Hospital Neurosurgical Service, Harvard Medical School, Boston, Massachusetts; ¹² Department of Hematology and Medical Oncology and ¹³ Adult Neuro-oncology Brain Tumor Institute, Cleveland Clinic Foundation, Cleveland, Ohio; ¹⁴ Department of Physiology and Biophysics, Chicago Medical School, North Chicago, Illinois; ¹⁵ Department of Neurosurgery, Massachusetts General Hospital-East Molecular Neurosurgery Laboratory, Harvard Medical School, Charlestown, Massachusetts; and ¹⁶ Department of Pharmaceutical Sciences, Texas Tech, Amarillo, Texas

Requests for reprints: Edward A. Neuwelt, Department of Neurology, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road-L603. Portland, OR 97201. Phone: 503-494-5626; Fax: 1-503 494-5627; E-mail: neuwelte{at}ohsu.edu .

The blood-brain barrier (BBB) presents a major obstacle to the treatment of malignant brain tumors and other central nervous system (CNS) diseases. For this reason, a meeting partially funded by an NIH R13 grant was convened to discuss recent advances and future directions in translational research in neuro-oncology and the BBB. Cell biology and transport across the BBB, delivery of agents to the CNS, neuroimaging, angiogenesis, immunotherapy, and gene therapy, as well as glioma, primary CNS lymphoma, and metastases to the CNS were discussed. Transport across the BBB relates to the neurovascular unit, which consists not only of endothelial cells but also of pericyte, glia, and neuronal elements.

Key Words: brain tumors • gene therapy • immunotherapy • angiogenesis • brain delivery • chemoprotection