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Clinical Cancer Research Vol. 11, 7322-7327, October 15, 2005
© 2005 American Association for Cancer Research

Imaging, Diagnosis, Prognosis

Increased Intratumor V{alpha}24-Positive Natural Killer T Cells: A Prognostic Factor for Primary Colorectal Carcinomas

Tsuyoshi Tachibana1, Hisashi Onodera1, Tatsuaki Tsuruyama2, Akira Mori1, Satoshi Nagayama1, Hiroshi Hiai3 and Masayuki Imamura1

Authors' Affiliations: Departments of 1 Surgery and Surgical Basic Science, and 2 Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Kyoto, and 3 Shiga Medical Center for Adults, Shiga, Japan

Requests for reprints: Hisashi Onodera, Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawara-cho, Sakyo-ku, Kyoto 606-8507, Japan. Phone: 81-75-751-3627; Fax: 81-75-751-3219; E-mail: onohisa{at}kuhp.kyoto-u.ac.jp.

Purpose: Human invariant natural killer T (NKT) cells are novel, distinct lymphocyte populations with a restricted T-cell receptor repertoire (V{alpha}24-Vß11). They play a pivotal role in immunoregulation and in antitumor activities. This study focused on V{alpha}24+ NKT cells in colorectal carcinomas and their clinicopathologic significance.

Experimental Design: V{alpha}24+ NKT-cell infiltration immunohistochemistry was studied in a total of 103 colorectal carcinoma cases. The degree of NKT-cell infiltration in tumors was evaluated as low (<7 NKT cells/5 HPF) or high (≥7 NKT cells/5 HPF). The correlation between the degree of infiltrated V{alpha}24+ NKT cells and clinicopathologic variables was studied statistically.

Results: A small number of V{alpha}24+ NKT cells were found in the normal colorectal mucosa (2.6 ± 3.7 cells/5 HPF); however, their number increased remarkably in colorectal carcinomas (15.2 ± 16.3 cells/5 HPF; P = 0.0003) and a majority showed phenotype of activation. Higher NKT-cell infiltration was more frequent in women than in men (P = 0.034) and correlated with fewer lymph node metastases (P = 0.042). Patients with high NKT-cell infiltration showed higher overall (P = 0.018) as well as disease-free (P = 0.0006) survival rates. Intratumor NKT-cell infiltration was an independent prognostic factor for the overall (P = 0.033) and disease-free (P = 0.0064) survival rates.

Conclusions: Increased infiltration of V{alpha}24+ NKT cells was observed in colorectal carcinomas. Higher V{alpha}24+ NKT-cell infiltration in colorectal carcinomas was an independent prognostic factor for favorable prognosis.




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