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Imaging, Diagnosis, Prognosis |
Authors' Affiliations: 1 Department of Otolaryngology Head and Neck Surgery, Universitätsklinikum Ulm, Ulm, Germany; Institutes of 2 Pathology and 3 Biomathematics and Biometry, GSF-National Research Center for Environment and Health, Neuherberg, Germany; 4 Department of Otolaryngology Head and Neck Surgery, Technical University of Munich, Munich, Germany; and 5 Institute of Pathology, Universitätsklinikum Freiburg, Freiburg, Germany
Requests for reprints: Axel Walch, Institut für Pathologie, GSF-Forschungszentrum für Umwelt und Gesundheit, Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany. Phone: 49-89-3187-2739; Fax: 49-89-3187-3349; E-mail: axel.walch{at}gsf.de.
Purpose: Aurora kinase A (AURKA/STK15/BTAK) encodes a serine/threonine kinase associated with chromosomal distribution and its up-regulation induces chromosomal instability, thereby leading to aneuploidy and cell transformation in several types of cancer. In this study, we investigated the role of AURKA in head and neck squamous cell carcinoma (HNSCC).
Experimental Design: The mRNA expression levels of AURKA were compared in tumor tissues of 66 HNSCC patients with those in corresponding normal squamous epithelium by real-time quantitative reverse transcriptase-PCR. In addition, the association between AURKA mRNA and protein expression, centrosome abnormalities, and aneuploidy was studied in a subset of cases (n = 34). All molecular variables were correlated to histomorphologic findings and clinical follow-up data of the patients.
Results: AURKA mRNA up-regulation was significantly associated with tumor stage and the occurrence of regional lymph node, as well as distant metastasis (P < 0.0001 for all). Similarly, a correlation was found for protein expression and the occurrence of regional lymph node (P = 0.0183) and distant metastasis (P = 0.03). The mRNA was positively associated with protein expression (P = 0.003) and centrosome abnormalities (P = 0.03). Cox regression analysis revealed that AURKA mRNA up-regulation correlated with disease-free survival of the patients (P = 0.03) as well as shorter overall survival (P < 0.001).
Conclusions: We conclude that the up-regulation of AURKA mRNA may play a critical role in the tumor progression of HNSCC and provides useful information as a prognostic factor for HNSCC patients.
Commentaries
Clin. Cancer Res. 2006 12: 5003-5004.
Clin. Cancer Res. 2006 12: 5005-5006.
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