Clinical Cancer Research CR Balducci Advances in Breast Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carvajal, R. D.
Right arrow Articles by Schwartz, G. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carvajal, R. D.
Right arrow Articles by Schwartz, G. K.
Related Collections
Right arrow Therapeutics and Targets
Right arrow Therapeutics and Targets: Identification, Validation, and Markers
Clinical Cancer Research Vol. 12, 6869-6875, December 1, 2006
© 2006 American Association for Cancer Research

Reviews

Aurora Kinases: New Targets for Cancer Therapy

Richard D. Carvajal3, Archie Tse1 and Gary K. Schwartz2

Authors' Affiliations: 1 Gastrointestinal Oncology Service and 2 Melanoma/Sarcoma Service, Laboratory of New Drug Development and 3 Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York

Requests for reprints: Gary K. Schwartz, Melanoma/Sarcoma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021. Phone: 212-639-8324; Fax: 212-717-3320; E-mail: schwartg{at}mskcc.org.

The Aurora kinase family is a collection of highly related serine/threonine kinases that functions as a key regulator of mitosis. In mammalian cells, Aurora has evolved into three related kinases known as Aurora-A, Aurora-B, and Aurora-C. These kinases are overexpressed in a number of human cancers, and transfection studies have established Aurora-A as a bone fide oncogene. Because Aurora overexpression is associated with malignancy, these kinases have been targeted for cancer therapy. This article reviews the multiple functions of Aurora kinase in the regulation of mitosis and the mitotic checkpoint, the role of abnormal Aurora kinase activity in the development of cancer, the putative mechanisms of Aurora kinase inhibition and its antitumor effects, the development of the first generation of Aurora kinase inhibitors, and prospects for the future of Aurora kinase inhibition in the treatment of cancer.




This article has been cited by other articles:


Home page
 Mol. Biol. CellHome page
J. S. Nair, A. L. Ho, A. N. Tse, J. Coward, H. Cheema, G. Ambrosini, N. Keen, and G. K. Schwartz
Aurora B Kinase Regulates the Postmitotic Endoreduplication Checkpoint via Phosphorylation of the Retinoblastoma Protein at Serine 780
Mol. Biol. Cell, April 15, 2009; 20(8): 2218 - 2228.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
E. C. VanderPorten, P. Taverna, J. N. Hogan, M. D. Ballinger, W. M. Flanagan, and R. V. Fucini
The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model
Mol. Cancer Ther., April 1, 2009; 8(4): 930 - 939.
[Abstract] [Full Text] [PDF]

Home page
 CA Cancer J ClinHome page
W. W. Ma and A. A. Adjei
Novel Agents on the Horizon for Cancer Therapy
CA Cancer J Clin, March 1, 2009; 59(2): 111 - 137.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
D. O. Cowley, J. A. Rivera-Perez, M. Schliekelman, Y. J. He, T. G. Oliver, L. Lu, R. O'Quinn, E. D. Salmon, T. Magnuson, and T. Van Dyke
Aurora-A Kinase Is Essential for Bipolar Spindle Formation and Early Development
Mol. Cell. Biol., February 15, 2009; 29(4): 1059 - 1071.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T.-L. Cha, M.-J. Chuang, S.-T. Wu, G.-H. Sun, S.-Y. Chang, D.-S. Yu, S.-M. Huang, S. K.-H. Huan, T.-C. Cheng, T.-T. Chen, et al.
Dual Degradation of Aurora A and B Kinases by the Histone Deacetylase Inhibitor LBH589 Induces G2-M Arrest and Apoptosis of Renal Cancer Cells
Clin. Cancer Res., February 1, 2009; 15(3): 840 - 850.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. Ochi, H. Fujiwara, K. Suemori, T. Azuma, Y. Yakushijin, T. Hato, K. Kuzushima, and M. Yasukawa
Aurora-A kinase: a novel target of cellular immunotherapy for leukemia
Blood, January 1, 2009; 113(1): 66 - 74.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
K. Wakahara, T. Ohno, M. Kimura, T. Masuda, S. Nozawa, T. Dohjima, T. Yamamoto, A. Nagano, G. Kawai, A. Matsuhashi, et al.
EWS-Fli1 Up-Regulates Expression of the Aurora A and Aurora B Kinases
Mol. Cancer Res., December 1, 2008; 6(12): 1937 - 1945.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L.-Y. Lu, J. L. Wood, L. Ye, K. Minter-Dykhouse, T. L. Saunders, X. Yu, and J. Chen
Aurora A Is Essential for Early Embryonic Development and Tumor Suppression
J. Biol. Chem., November 14, 2008; 283(46): 31785 - 31790.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W. Fiskus, Y. Wang, R. Joshi, R. Rao, Y. Yang, J. Chen, R. Kolhe, R. Balusu, K. Eaton, P. Lee, et al.
Cotreatment with Vorinostat Enhances Activity of MK-0457 (VX-680) against Acute and Chronic Myelogenous Leukemia Cells
Clin. Cancer Res., October 1, 2008; 14(19): 6106 - 6115.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Kojima, M. Konopleva, T. Tsao, H. Nakakuma, and M. Andreeff
Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia
Blood, October 1, 2008; 112(7): 2886 - 2895.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. G. Lin, A. Immaneni, W. M. Merritt, L. S. Mangala, S. W. Kim, M. M.K. Shahzad, Y. T.M. Tsang, G. N. Armaiz-Pena, C. Lu, A. A. Kamat, et al.
Targeting Aurora Kinase with MK-0457 Inhibits Ovarian Cancer Growth
Clin. Cancer Res., September 1, 2008; 14(17): 5437 - 5446.
[Abstract] [Full Text] [PDF]

Home page
 aacredbookHome page
T. L Schmit and N. Ahmad
Regulation of Mitosis via Mitotic Kinases: New Opportunities for Cancer Management
Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 133 - 150.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. Finetti, N. Cervera, E. Charafe-Jauffret, C. Chabannon, C. Charpin, M. Chaffanet, J. Jacquemier, P. Viens, D. Birnbaum, and F. Bertucci
Sixteen-Kinase Gene Expression Identifies Luminal Breast Cancers with Poor Prognosis
Cancer Res., February 1, 2008; 68(3): 767 - 776.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
P. Carpinelli, R. Ceruti, M. L. Giorgini, P. Cappella, L. Gianellini, V. Croci, A. Degrassi, G. Texido, M. Rocchetti, P. Vianello, et al.
PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer
Mol. Cancer Ther., December 1, 2007; 6(12): 3158 - 3168.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Yang, T. Ikezoe, C. Nishioka, T. Tasaka, A. Taniguchi, Y. Kuwayama, N. Komatsu, K. Bandobashi, K. Togitani, H. P. Koeffler, et al.
AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo
Blood, September 15, 2007; 110(6): 2034 - 2040.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Lassmann, Y. Shen, U. Jutting, P. Wiehle, A. Walch, G. Gitsch, A. Hasenburg, and M. Werner
Predictive Value of Aurora-A/STK15 Expression for Late Stage Epithelial Ovarian Cancer Patients Treated by Adjuvant Chemotherapy
Clin. Cancer Res., July 15, 2007; 13(14): 4083 - 4091.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. N. Landen Jr., Y. G. Lin, A. Immaneni, M. T. Deavers, W. M. Merritt, W. A. Spannuth, D. C. Bodurka, D. M. Gershenson, W. R. Brinkley, and A. K. Sood
Overexpression of the Centrosomal Protein Aurora-A Kinase is Associated with Poor Prognosis in Epithelial Ovarian Cancer Patients
Clin. Cancer Res., July 15, 2007; 13(14): 4098 - 4104.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
T. L. Schmit and N. Ahmad
Regulation of mitosis via mitotic kinases: new opportunities for cancer management
Mol. Cancer Ther., July 1, 2007; 6(7): 1920 - 1931.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
I. Irminger-Finger
Science of Cancer and Aging
J. Clin. Oncol., May 10, 2007; 25(14): 1844 - 1851.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2006 by the American Association for Cancer Research.