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Imaging Tumor Vascular Heterogeneity and Angiogenesis using Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Authors' Affiliations: ¹ Imaging Science and Biomedical Engineering, University of Manchester and ² Cancer Research UK, Department of Medical Oncology, Christie Hospital, Manchester, United Kingdom

Requests for reprints: James P.B. O'Connor, Imaging Science and Biomedical Engineering, University of Manchester, Ground Floor, Stopford Building, Oxford Road, Manchester M13 9PT, United Kingdom. Phone: 44-161-275-5770; Fax: 44-161-275-1138; E-mail: james.o'connor{at}manchester.ac.uk.

Abstract

This article reviews the application of dynamic contrast-enhanced magnetic resonance imaging in both clinical studies and early-phase trials of angiogenesis inhibitors. Emphasis is placed on how variation in image acquisition and analysis affects the meaning and use of derived variables. We then review the potential for future developments, with particular reference to the application of dynamic contrast-enhanced magnetic resonance imaging to evaluate the heterogeneity of tumor tissues.

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