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Molecular Pathways for Cancer Angioprevention

Authors' Affiliations: ¹ IRCCS Multimedica, Milan, Italy; ² Università degli Studi dell'Insubria, Varese, Italy; and ³ Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy

Requests for reprints: Adriana Albini, IRCCS Multimedica, Viale Fantoli 16/15, 20138 Milan, Italy. Phone: 39-25540-6574; Fax: 39-25540-6570; E-mail: adriana.albini{at}multimedica.it.

Abstract

By analogy to the success of cardiovascular medicine in reducing mortality through preventive measures, cancer chemoprevention has the potential to significantly reduce incidence and mortality due to tumors. Angiogenesis is an event inhibited by most of the promising cancer chemoprevention compounds, a concept we termed "angioprevention." Here, we review the signaling pathways that are targeted by diverse angioprevention compounds in endothelial cells. We highlight diverse mechanisms of action, implying that combination angioprevention approaches could further improve efficacy and be transferred to clinical practice.

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