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Input of DNA Microarrays to Identify Novel Mechanisms in Multiple Myeloma Biology and Therapeutic Applications

Authors' Affiliations: ¹ CHU Montpellier, Institut de Recherche en Biothérapies, Hôpital Saint-Eloi; ² Institut National de la Sante et de la Recherche Medicale, U847; ³ Université Montpellier1, UFR de Médecine; ⁴ CHU Montpellier, Service d'Hématologie et d'Oncologie Médicale, Montpellier, France; and ⁵ Medizinische Klinik und Poliklinik V, Universitätsklinikum Heidelberg, Germany

Requests for reprints: Bernard Klein, Institut de Recherche en Biothérapies, CHU Montpellier, Hôpital Saint-Eloi, Av Augustin Fliche, Montpellier F-34285, France. Phone: 33-4-67-33-78-88; Fax: 33-4-67-33-70-05; E-mail: klein{at}montp.inserm.fr.

Multiple myeloma is a B-cell neoplasia characterized by the proliferation of a clone of malignant plasma cells in the bone marrow. We review here the input of gene expression profiling of myeloma cells and of their tumor microenvironment to develop new tumor classifiers, to better understand the biology of myeloma cells, to identify some mechanisms of drug sensitivity and resistance, to identify new myeloma growth factors, and to depict the complex interactions between tumor cells and their microenvironment. We discuss how these findings may improve the clinical outcome of this still incurable disease.

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				G. C. Prendergast Metastasis, miRNAs, Multiple Myeloma, and More Cancer Reviews Online Content, January 1, 2008; 2008(1): 1 - 1. [Full Text] [PDF]