This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Google Scholar Articles by Dorfman, G. S. PubMed PubMed Citation Articles by Dorfman, G. S. Related Collections Clinical Research Clinical Research: Imaging, Diagnosis, and Prognosis Therapeutics and Targets Therapeutics and Targets: Identification, Validation, and Markers

The Translational Research Working Group Developmental Pathway for Image-Based Assessment Modalities

Authors' Affiliations: ¹ Weill Cornell Medical College, New York, New York; ² Duke University, Durham, North Carolina; ³ University of Pennsylvania, Philadelphia, Pennsylvania; and ⁴ Vanderbilt University, Nashville, Tennessee

Requests for reprints: Lynn M. Matrisian, Department of Cancer Biology, 771 PRB, 2220 Pierce Avenue, Nashville, TN 37232-6840. Phone: 615-322-0375; Fax: 615-936-2911; E-mail: Lynn.matrisian{at}vanderbilt.edu.

Abstract

The Image-based assessment modality (IM) pathway refers to one of six Translational Research Working Group (TRWG) pathways that, together, describe the core domains of early translational cancer research. This pathway focuses on approaches that are based on the interaction of energy and living organisms to analyze tissue noninvasively so as to reveal properties relevant to the detection, diagnosis, or prognosis of cancer and precancer; or the response of the cancer to therapy. Examples include, but are not limited to, magnetic resonance imaging and positron emission tomography, as well as contemporary contrast agents designed to probe specific molecular constituents of tumors. The IM pathway is presented as a general outline of the steps required for the effective development, optimization, testing, and validation of image-based modalities. The distinctive features of the IM pathway and issues encountered that represent obstacles to effective and efficient progress through the pathway are discussed. The IM pathway also forms a framework to identify opportunities to address current barriers and is expected to adapt and evolve as the field advances.

This article has been cited by other articles:

				E. T. Hawk, L. M. Matrisian, W. G. Nelson, G. S. Dorfman, L. Stevens, J. Kwok, J. Viner, J. Hautala, O. Grad, and for the Translational Research Working Group The Translational Research Working Group Developmental Pathways: Introduction and Overview Clin. Cancer Res., September 15, 2008; 14(18): 5664 - 5671. [Abstract] [Full Text] [PDF]

				G. C. Prendergast Cancer Research: Historical Overviews and Better Translational Pathways Cancer Reviews Online Content, January 1, 2008; 2008(10): 19 - 20. [Full Text] [PDF]