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Colon Cancer: It's CIN or CIMP

Author's Affiliation: University of Texas M. D. Anderson Cancer Center, Houston, Texas

Requests for reprints: Jean-Pierre Issa, Department of Leukemia, M. D. Anderson Cancer Center, Unit 428, 1515 Holcombe, Houston, TX 77030. Phone: 713-745-2260; Fax: 713-794-4297; E-mail: jpissa{at}mdanderson.org.

Abstract

Combined genetic and epigenetic analysis of sporadic colon cancer suggest that it can no longer be viewed as a single disease. There are at least three different subsets with distinct clinico-pathologic features, with important implications for preventions, screening, and therapy.

Key Article

CpG Island Methylator Phenotype Associates with Low-Degree Chromosomal Abnormalities in Colorectal Cancer

Yu-Wei Cheng, Hanna Pincas, Manny D. Bacolod, Gunter Schemmann, Sarah F. Giardina, Jianmin Huang, Sandra Barral, Kamran Idrees, Sajid A. Khan, Zhaoshi Zeng, Shoshana Rosenberg, Daniel A. Notterman, Jurg Ott, Philip Paty, and Francis Barany
Clin. Cancer Res. 2008 14: 6005-6013. [Abstract] [Full Text] [PDF]