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v Integrins Lead the Way for Colorectal Metastases

Author's Affiliation: Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Houston, Texas

Requests for reprints: Joseph H. McCarty, Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Unit 173, 1515 Holcombe Boulevard, Houston, TX 77030. Phone: 713-792-0429; Fax: 713-792-8747; E-mail: jhmccarty{at}mdanderson.org.

Abstract

In this issue of Clinical Cancer Research, Conti et al. identify a crucial cell adhesion and signaling axis that promotes the proliferation, survival, and drug-resistant properties of metastatic colorectal cancer cells in the liver. The components of this pathway may be effective targets for therapeutically treating established metastatic tumors in patients with colorectal adenocarcinomas.

Key Article

The Desmoplastic Reaction Surrounding Hepatic Colorectal Adenocarcinoma Metastases Aids Tumor Growth and Survival via _v Integrin Ligation

John A. Conti, Timothy J. Kendall, Adrian Bateman, Thomas A. Armstrong, Andrew Papa-Adams, Qian Xu, Graham Packham, John N. Primrose, R. Christopher Benyon, and John P. Iredale
Clin. Cancer Res. 2008 14: 6405-6413. [Abstract] [Full Text] [PDF]