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The Challenge of Herbal Therapies for Prostate Cancer

Authors' Affiliation: Cancer Biology and Division of Hematology-Oncology. Beth Israel Deaconess Medical Center and Harvard Medical School. Boston, Massachusetts

Requests for reprints: Glenn J. Bubley, Beth Israel Deaconess Medical Center, CLS: Room 449, 330 Brookline Avenue, Boston, MA 02215. E-mail: gbubley{at}bidmc.harvard.edu.

Abstract

The paper by Singh et al. shows that silibinin inhibits prostate cancer growth in the TRAMP mouse model. Among its other properties, silibinin inhibits the progression of prostate cancer by decreasing angiogenesis and tumor invasion. Identification of the biological effects of herbal remedies such as silibinin is critical for their development as anticancer treatments.

Key Article

Silibinin Inhibits Established Prostate Tumor Growth, Progression, Invasion, and Metastasis and Suppresses Tumor Angiogenesis and Epithelial-Mesenchymal Transition in Transgenic Adenocarcinoma of the Mouse Prostate Model Mice

Rana P. Singh, Komal Raina, Girish Sharma, and Rajesh Agarwal
Clin. Cancer Res. 2008 14: 7773-7780. [Abstract] [Full Text] [PDF]