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Focal Adhesion Kinase: Targeting Adhesion Signaling Pathways for Therapeutic Intervention

Authors' Affiliations: ¹ Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia and ² Pfizer Oncology, Groton, Connecticut

Requests for reprints: J. Thomas Parsons, Department of Microbiology, University of Virginia Health System, P.O. Box 800734, Charlottesville, VA 22908. Phone: 434-924-5395; Fax: 434-982-1071; E-mail: jtp{at}virginia.edu.

Abstract

The tumor microenvironment plays a central role in cancer progression and metastasis. Within this environment, cancer cells respond to a host of signals including growth factors and chemotactic factors, as well as signals from adjacent cells, cells in the surrounding stroma, and signals from the extracellular matrix. Targeting the pathways that mediate many of these signals has been a major goal in the effort to develop therapeutics.