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The Use of Magnetic Resonance Imaging to Noninvasively Detect Genetic Signatures in Oligodendroglioma

Authors' Affiliations: Departments of ¹ Electrical and Computer Engineering, ² Clinical Neurosciences, ³ Oncology, ⁴ Radiology, and ⁵ Pathology and Laboratory Medicine, ⁶ Seaman Family MR Research Centre, ⁷ Clark Smith Brain Tumor Centre of the Southern Alberta Cancer Research Institute, and ⁸ Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta; and ⁹ Department of Neurology, University of Virginia, Charlottesville, Virginia

Requests for reprints: Gregory Cairncross, Foothills Medical Centre, 1403 29th Street Northwest, Calgary, Alberta, Canada T2N 2T9. Phone: 403-944-1260; Fax: 403-270-7878; E-mail: jgcairnx{at}ucalgary.ca.

Background: Some patients with low-grade glioma have extraordinarily long survival times; current, early treatment does not prolong their lives. For this reason, therapies that sometimes have neurologic side effects are often deferred intentionally.

Methods: In a study of oligodendrogliomas, we used a quantitative method of MR analysis based on the S-transform to investigate whether codeletion of chromosomes 1p and 19q, a marker of good prognosis, could be predicted accurately by measuring image texture.

Results: Differences in texture were seen between tumors with codeletion of chromosomes 1p and 19q and those with intact 1p and 19q alleles on contrast-enhanced T1-weighted and T2-weighted MR images. Quantitative MR texture on T2 images predicted codeletion of chromosomes 1p and 19q with high sensitivity and specificity.

Conclusions: This new method of MR image interpretation may have the potential to augment the diagnostic assessment of patients with suspected low-grade glioma.