Clinical Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention
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Clinical Cancer Research, Vol 2, Issue 9 1439-1444, Copyright © 1996 by American Association for Cancer Research

ARTICLES

Alteration of p53 damage response by tamoxifen treatment

C Guillot, N Falette, S Courtois, T Voeltzel, E Garcia, M Ozturk and A Puisieux
INSERM U453, and Unite d'Oncologie Moleculaire, Centre Leon Berard, 28 rue Laennec, 69008 Lyon, France.

Hormone therapy is often used in association with chemotherapy in the treatment of estrogen-responsive breast cancers. By using breast adenocarcinoma cell lines, we show that antiestrogen treatment leads to a dramatic decrease of p53 protein levels. This effect leads to a loss of wild-type p53 response to genotoxic treatment. This inhibition is assessed by the lack of p53 protein accumulation and the loss of the p53-dependent induction of p21(WAF1/CIP1) expression. Given that the effects of several anticancer agents are mediated through DNA damage, these observations suggest that antiestrogen treatment could modulate cellular response to chemotherapeutic agents.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1996 by the American Association for Cancer Research.