| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Clinical Cancer Research, Vol 3, Issue 11 1949-1958, Copyright © 1997 by American Association for Cancer Research
ARTICLES |
MD Sternlicht, P Kedeshian, ZM Shao, S Safarians and SH Barsky
Department of Pathology, UCLA School of Medicine, Los Angeles, California 90024, USA.
Myoepithelial cells, which surround ducts and acini of glandular organs, form a natural border separating proliferating epithelial cells from basement membrane and underlying stroma. Myoepithelial cells in situ and in vitro constitutively express high amounts of proteinase inhibitors that include tissue inhibitor of metalloproteinase 1, protease nexin-II, alpha-1 antitrypsin, and maspin. Human myoepithelial xenografts (HMS-X, HMS-3X, and HMS-4X), which our laboratory has established, accumulate an abundant extracellular matrix containing sequestered proteinase inhibitors. Humatrix, a gel that we have derived from HMS-X, inhibits tumor cell invasion (down to 25% +/- 10% of Matrigel control; P < 0.01), and our recently established human myoepithelial cell lines, HMS-1, HMS-3, and HMS-4, inhibit tumor cell invasion in cellular invasion (down to 42% +/- 7% of control; P < 0.05) and in conditioned media assays (down to 30% +/- 8% of control; P < 0.01). The anti-invasive effects of HMS-1, HMS-3, and HMS-4 can be enhanced by phorbol 12-myristate 13-acetate (down to 2% +/- 1% of control) by a maspin-dependent mechanism and abolished by dexamethasone (up to 95% +/- 5% of control) by a maspin-independent mechanism (P < 0.01). HMS-X, HMS-3X, HMS-4X, and Humatrix inhibit tumor invasion and metastasis in severe combined immunodeficient mice (P < 0.001). The cumulative data suggest that myoepithelial cells are natural paracrine suppressors of invasion and metastasis and may specifically inhibit the progression of precancerous disease states to invasive cancer in vivo.
This article has been cited by other articles:
|
|
 |
|
  R.-A. Toillon, C. Lagadec, A. Page, V. Chopin, P.-E. Sautiere, J.-M. Ricort, J. Lemoine, M. Zhang, H. Hondermarck, and X. Le Bourhis Proteomics Demonstration That Normal Breast Epithelial Cells Can Induce Apoptosis of Breast Cancer Cells through Insulin-like Growth Factor-binding Protein-3 and Maspin Mol. Cell. Proteomics, July 1, 2007; 6(7): 1239 - 1247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lacroix Significance, detection and markers of disseminated breast cancer cells Endocr. Relat. Cancer, December 1, 2006; 13(4): 1033 - 1067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Li, S. Chang, X. Qi, J. A. Richardson, and E. N. Olson Requirement of a Myocardin-Related Transcription Factor for Development of Mammary Myoepithelial Cells Mol. Cell. Biol., August 1, 2006; 26(15): 5797 - 5808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Vargo-Gogola, B. M. Heckman, E. J. Gunther, L. A. Chodosh, and J. M. Rosen P190-B Rho GTPase-Activating Protein Overexpression Disrupts Ductal Morphogenesis and Induces Hyperplastic Lesions in the Developing Mammary Gland Mol. Endocrinol., June 1, 2006; 20(6): 1391 - 1405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M T Martins, A Altemani, L Freitas, and V C Araujo Maspin expression in carcinoma ex pleomorphic adenoma J. Clin. Pathol., December 1, 2005; 58(12): 1311 - 1314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Ivanova, S-Y Liao, M I Lerman, S Ivanov, and E J Stanbridge STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker J. Med. Genet., July 1, 2005; 42(7): 565 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Espinosa de los Monteros, M. Y. Millan, G. A. Ramirez, J. Ordas, C. Reymundo, and J. Martin de las Mulas Expression of Maspin in Mammary Gland Tumors of the Dog Vet. Pathol., May 1, 2005; 42(3): 250 - 257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Latha, W. Zhang, N. Cella, H. Y. Shi, and M. Zhang Maspin Mediates Increased Tumor Cell Apoptosis upon Induction of the Mitochondrial Permeability Transition Mol. Cell. Biol., March 1, 2005; 25(5): 1737 - 1748. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Teuliere, M. M. Faraldo, M.-A. Deugnier, M. Shtutman, A. Ben-Ze'ev, J. P. Thiery, and M. A. Glukhova Targeted activation of {beta}-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia Development, January 15, 2005; 132(2): 267 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Lacroix, R-A Toillon, and G Leclercq Stable 'portrait' of breast tumors during progression: data from biology, pathology and genetics Endocr. Relat. Cancer, September 1, 2004; 11(3): 497 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Khalkhali-Ellis, A. L. Christian, D. A. Kirschmann, E. M. Edwards, M. Rezaie-Thompson, M. A. Vasef, L. M. Gruman, R. E. B. Seftor, L. E. Norwood, and M. J. C. Hendrix Regulating the Tumor Suppressor Gene Maspin in Breast Cancer Cells: A Potential Mechanism for the Anticancer Properties of Tamoxifen Clin. Cancer Res., January 15, 2004; 10(2): 449 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. V. Offersen, B. S. Nielsen, G. Hoyer-Hansen, F. Rank, S. Hamilton-Dutoit, J. Overgaard, and P. A. Andreasen The Myofibroblast Is the Predominant Plasminogen Activator Inhibitor-1-Expressing Cell Type in Human Breast Carcinomas Am. J. Pathol., November 1, 2003; 163(5): 1887 - 1899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-K. Tai, O. J.-K. Tan, V. T.-K. Chow, R. Jin, J. L. Jones, P.-H. Tan, A. Jayasurya, and B.-H. Bay Differential Expression of Metallothionein 1 and 2 Isoforms in Breast Cancer Lines with Different Invasive Potential: Identification of a Novel Nonsilent Metallothionein-1H Mutant Variant Am. J. Pathol., November 1, 2003; 163(5): 2009 - 2019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ngamkitidechakul, D. J. Warejcka, J. M. Burke, W. J. O'Brien, and S. S. Twining Sufficiency of the Reactive Site Loop of Maspin for Induction of Cell-Matrix Adhesion and Inhibition of Cell Invasion: CONVERSION OF OVALBUMIN TO A MASPIN-LIKE MOLECULE J. Biol. Chem., August 22, 2003; 278(34): 31796 - 31806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Pia-Foschini, J S Reis-Filho, V Eusebi, and S R Lakhani Salivary gland-like tumours of the breast: surgical and molecular pathology J. Clin. Pathol., July 1, 2003; 56(7): 497 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Schmeichel and M. J. Bissell Modeling tissue-specific signaling and organ function in three dimensions J. Cell Sci., June 15, 2003; 116(12): 2377 - 2388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Khalkhali-Ellis and M. J. C. Hendrix Nitric Oxide Regulation of Maspin Expression in Normal Mammary Epithelial and Breast Cancer Cells Am. J. Pathol., May 1, 2003; 162(5): 1411 - 1417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rosner, K. Miyoshi, E. Landesman-Bollag, X. Xu, D. C. Seldin, A. R. Moser, C. L. MacLeod, G. Shyamala, A. E. Gillgrass, and R. D. Cardiff Pathway Pathology : Histological Differences Between ErbB/Ras and Wnt Pathway Transgenic Mammary Tumors Am. J. Pathol., September 1, 2002; 161(3): 1087 - 1097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Alpaugh, J. S. Tomlinson, Y. Ye, and S. H. Barsky Relationship of Sialyl-Lewisx/a Underexpression and E-Cadherin Overexpression in the Lymphovascular Embolus of Inflammatory Breast Carcinoma Am. J. Pathol., August 1, 2002; 161(2): 619 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V Speirs, G P Skliris, S E Burdall, and P J Carder Distinct expression patterns of ER{alpha} and ER{beta} in normal human mammary gland J. Clin. Pathol., May 1, 2002; 55(5): 371 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Gudjonsson, L. Ronnov-Jessen, R. Villadsen, F. Rank, M. J. Bissell, and O. W. Petersen Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition J. Cell Sci., January 1, 2002; 115(1): 39 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Y Shi, W. Zhang, R. Liang, S. Abraham, F. S. Kittrell, D. Medina, and M. Zhang Blocking Tumor Growth, Invasion, and Metastasis by Maspin in a Syngeneic Breast Cancer Model Cancer Res., September 1, 2001; 61(18): 6945 - 6951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Tomlinson, M. L. Alpaugh, and S. H. Barsky An Intact Overexpressed E-cadherin/{{alpha}},{beta}-Catenin Axis Characterizes the Lymphovascular Emboli of Inflammatory Breast Carcinoma Cancer Res., July 1, 2001; 61(13): 5231 - 5241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Liu, P. A. Pemberton, and A. D. Robertson Three-state Unfolding and Self-association of Maspin, a Tumor-suppressing Serpin J. Biol. Chem., October 15, 1999; 274(42): 29628 - 29632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Alpaugh, J. S. Tomlinson, Z.-M. Shao, and S. H. Barsky A Novel Human Xenograft Model of Inflammatory Breast Cancer Cancer Res., October 1, 1999; 59(20): 5079 - 5084. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
