Clinical Cancer Research, Vol 4, Issue 2 407-410, Copyright © 1998 by American Association for Cancer Research

ARTICLES

Prognostic value of alpha 6 beta 4 integrin expression in breast carcinomas is affected by laminin production from tumor cells

E Tagliabue, C Ghirelli, P Squicciarini, P Aiello, MI Colnaghi and S Menard
Division of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy.

Immunocytochemical analysis of breast carcinoma specimens for alpha 6 beta 4 integrin expression and other different pathobiological markers revealed beta 4 integrin subunit expression in 36 of 80 cases analyzed and a significant association only with alpha 6 integrin subunit expression (P < 0.01) and laminin production (P = 0.01) by tumor cells. Survival analysis indicated that beta 4 and alpha 6 expression are associated with poor prognosis (P = 0.02), whereas laminin production showed only borderline association (P = 0.06). However, analysis of disease outcome in relation to expression of both alpha 6 beta 4 and laminin indicated best outcomes for patients with tumors producing laminin but not expressing alpha 6 beta 4 integrin, whereas worst outcomes were observed for alpha 6 beta 4- and laminin-positive tumors, indicating that alpha 6 beta 4 expression was associated with prognosis, mainly in the laminin-producing tumor subset. These data indicate that the prognostic value of alpha 6 beta 4 integrin expression is affected by laminin production from tumor cells and suggest that interaction between these two molecules mediates distinct signals that are important for tumor progression.

This article has been cited by other articles:

				A. Brendle, H. Lei, A. Brandt, R. Johansson, K. Enquist, R. Henriksson, K. Hemminki, P. Lenner, and A. Forsti Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker Carcinogenesis, July 1, 2008; 29(7): 1394 - 1399. [Abstract] [Full Text] [PDF]

				J. C. Friedland, J. N. Lakins, M. G. Kazanietz, J. Chernoff, D. Boettiger, and V. M. Weaver {alpha}6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-{kappa}B-dependent resistance to apoptosis in 3D mammary acini J. Cell Sci., October 15, 2007; 120(20): 3700 - 3712. [Abstract] [Full Text] [PDF]

				S. M. Rodriguez-Pinilla, D. Sarrio, E. Honrado, G. Moreno-Bueno, D. Hardisson, F. Calero, J. Benitez, and J. Palacios Vimentin and laminin expression is associated with basal-like phenotype in both sporadic and BRCA1-associated breast carcinomas J. Clin. Pathol., September 1, 2007; 60(9): 1006 - 1012. [Abstract] [Full Text] [PDF]

				J. Chia, N. Kusuma, R. Anderson, B. Parker, B. Bidwell, L. Zamurs, E. Nice, and N. Pouliot Evidence for a Role of Tumor-Derived Laminin-511 in the Metastatic Progression of Breast Cancer Am. J. Pathol., June 1, 2007; 170(6): 2135 - 2148. [Abstract] [Full Text] [PDF]

				G. Bon, V. Folgiero, G. Bossi, L. Felicioni, A. Marchetti, A. Sacchi, and R. Falcioni Loss of {beta}4 Integrin Subunit Reduces the Tumorigenicity of MCF7 Mammary Cells and Causes Apoptosis upon Hormone Deprivation. Clin. Cancer Res., June 1, 2006; 12(11): 3280 - 3287. [Abstract] [Full Text] [PDF]

				S.-O. Yoon, S. Shin, and E. A. Lipscomb A Novel Mechanism for Integrin-Mediated Ras Activation in Breast Carcinoma Cells: The {alpha}6{beta}4 Integrin Regulates ErbB2 Translation and Transactivates Epidermal Growth Factor Receptor/ErbB2 Signaling. Cancer Res., March 1, 2006; 66(5): 2732 - 2739. [Abstract] [Full Text] [PDF]

				E. A. Lipscomb, K. J. Simpson, S. R. Lyle, J. E. Ring, A. S. Dugan, and A. M. Mercurio The {alpha}6{beta}4 Integrin Maintains the Survival of Human Breast Carcinoma Cells In vivo Cancer Res., December 1, 2005; 65(23): 10970 - 10976. [Abstract] [Full Text] [PDF]

				K S Nair, R Naidoo, and R Chetty Expression of cell adhesion molecules in oesophageal carcinoma and its prognostic value J. Clin. Pathol., April 1, 2005; 58(4): 343 - 351. [Abstract] [Full Text] [PDF]

				B. Davidson, S. Konstantinovsky, S. Nielsen, H. P. Dong, A. Berner, M. Vyberg, and R. Reich Altered Expression of Metastasis-Associated and Regulatory Molecules in Effusions from Breast Cancer Patients: A Novel Model for Tumor Progression Clin. Cancer Res., November 1, 2004; 10(21): 7335 - 7346. [Abstract] [Full Text] [PDF]

				L. K. Diaz, X. Zhou, K. Welch, A. Sahin, and M. Z. Gilcrease Chromogenic In Situ Hybridization for {alpha}6{beta}4 Integrin in Breast Cancer: Correlation with Protein Expression J. Mol. Diagn., February 1, 2004; 6(1): 10 - 15. [Abstract] [Full Text]

				N. Zahir, J. N. Lakins, A. Russell, W. Ming, C. Chatterjee, G. I. Rozenberg, M. P. Marinkovich, and V. M. Weaver Autocrine laminin-5 ligates {alpha}6{beta}4 integrin and activates RAC and NF{kappa}B to mediate anchorage-independent survival of mammary tumors J. Cell Biol., December 22, 2003; 163(6): 1397 - 1407. [Abstract] [Full Text] [PDF]

				M. Abdel-Ghany, H.-C. Cheng, R. C. Elble, H. Lin, J. DiBiasio, and B. U. Pauli The Interacting Binding Domains of the {beta}4 Integrin and Calcium-activated Chloride Channels (CLCAs) in Metastasis J. Biol. Chem., December 5, 2003; 278(49): 49406 - 49416. [Abstract] [Full Text] [PDF]

				G. van der Pluijm, B. Sijmons, H. Vloedgraven, C. van der Bent, J.-W. Drijfhout, J. Verheijen, P. Quax, M. Karperien, S. Papapoulos, and C. Lowik Urokinase-Receptor/Integrin Complexes Are Functionally Involved in Adhesion and Progression of Human Breast Cancer in Vivo Am. J. Pathol., September 1, 2001; 159(3): 971 - 982. [Abstract] [Full Text] [PDF]

				L. M. Shaw Identification of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 as Signaling Intermediates in the {alpha}6{beta}4 Integrin-Dependent Activation of Phosphoinositide 3-OH Kinase and Promotion of Invasion Mol. Cell. Biol., August 1, 2001; 21(15): 5082 - 5093. [Abstract] [Full Text] [PDF]

				G. J. Mizejewski Role of Integrins in Cancer: Survey of Expression Patterns Experimental Biology and Medicine, November 1, 1999; 222(2): 124 - 138. [Abstract] [Full Text]

				M. V. Carriero, S. D. Vecchio, M. Capozzoli, P. Franco, L. Fontana, A. Zannetti, G. Botti, G. D'Aiuto, M. Salvatore, and M. P. Stoppelli Urokinase Receptor Interacts with {{alpha}}v{{beta}}5 Vitronectin Receptor, Promoting Urokinase-dependent Cell Migration in Breast Cancer Cancer Res., October 1, 1999; 59(20): 5307 - 5314. [Abstract] [Full Text] [PDF]