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Clinical Cancer Research, Vol 4, Issue 3 693-696, Copyright © 1998 by American Association for Cancer Research
ARTICLES |
SM Melana, JF Holland and BG Pogo
Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.
The effect of zidovudine (3'-azido-3'-deoxythymidine; AZT) was investigated in four breast cancer cell lines, a T4 cell leukemia, and a normal breast cell line in vitro. AZT inhibited the growth of all tumoral cell lines, but it did so in a wide range of concentrations. The growth of a normal breast cell line was also inhibited, although it required a much higher concentration. Furthermore, AZT inhibited colony formation in soft agar and telomerase activity. These results indicated that AZT can be potentially used, alone or in combination, as an anti-breast cancer agent.
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