This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sato, N. Articles by Tanaka, M. Search for Related Content PubMed PubMed Citation Articles by Sato, N. Articles by Tanaka, M.

Centrosome Abnormalities in Pancreatic Ductal Carcinoma

Department of Surgery I, Kyushu University Faculty of Medicine, Fukuoka 812-8582, Japan

The centrosome plays an important role in microtubule nucleation and organization, ensuring the establishment of cell polarity and balanced chromosome segregation. Recent studies have suggested that the loss of cell polarity and/or chromosome missegregation (aneuploidy) in human malignant tumors could result from defects in centrosome function. Using immunofluorescence analysis with an antibody to -tubulin (a well-characterized centrosomal component), we examined surgically resected human pancreatic tissues for centrosome abnormalities. The tissues included ductal carcinomas (n = 13), adenomas (n = 3), endocrine tumors (n = 3), chronic pancreatitis (n = 5), and normal pancreatic tissues (n = 12). We found that most (85%) carcinomas and some adenomas displayed abnormal centrosome profiles, characterized by an increase in size and number of centrosomes, and by their irregular distribution. In contrast, none of normal ductal and stromal tissues showed these abnormalities. These findings suggest that centrosome abnormalities may develop at a relatively early stage of pancreatic ductal carcinogenesis.

This article has been cited by other articles:

				W. J. Chng, E. Braggio, G. Mulligan, B. Bryant, E. Remstein, R. Valdez, A. Dogan, and R. Fonseca The centrosome index is a powerful prognostic marker in myeloma and identifies a cohort of patients that might benefit from aurora kinase inhibition Blood, February 1, 2008; 111(3): 1603 - 1609. [Abstract] [Full Text] [PDF]

				A. D. Slack, Z. Chen, A. D. Ludwig, J. Hicks, and J. M. Shohet MYCN-Directed Centrosome Amplification Requires MDM2-Mediated Suppression of p53 Activity in Neuroblastoma Cells Cancer Res., March 15, 2007; 67(6): 2448 - 2455. [Abstract] [Full Text] [PDF]

				A. F. Hezel, A. C. Kimmelman, B. Z. Stanger, N. Bardeesy, and R. A. DePinho Genetics and biology of pancreatic ductal adenocarcinoma. Genes & Dev., May 15, 2006; 20(10): 1218 - 1249. [Abstract] [Full Text] [PDF]

				W. J. Chng, G. J. Ahmann, K. Henderson, R. Santana-Davila, P. R. Greipp, M. A. Gertz, M. Q. Lacy, A. Dispenzieri, S. Kumar, S. V. Rajkumar, et al. Clinical implication of centrosome amplification in plasma cell neoplasm Blood, May 1, 2006; 107(9): 3669 - 3675. [Abstract] [Full Text] [PDF]

				Q. Wang, X. Du, J. Meinkoth, Y. Hirohashi, H. Zhang, Q. Liu, M. Richter, and M. I. Greene Characterization of Su48, a centrosome protein essential for cell division PNAS, April 25, 2006; 103(17): 6512 - 6517. [Abstract] [Full Text] [PDF]

				E. Sugihara, M. Kanai, S. Saito, T. Nitta, H. Toyoshima, K. Nakayama, K. I. Nakayama, K. Fukasawa, M. Schwab, H. Saya, et al. Suppression of Centrosome Amplification after DNA Damage Depends on p27 Accumulation. Cancer Res., April 15, 2006; 66(8): 4020 - 4029. [Abstract] [Full Text] [PDF]

				K. Hida, Y. Hida, D. N. Amin, A. F. Flint, D. Panigrahy, C. C. Morton, and M. Klagsbrun Tumor-Associated Endothelial Cells with Cytogenetic Abnormalities Cancer Res., November 15, 2004; 64(22): 8249 - 8255. [Abstract] [Full Text] [PDF]

				S. Rojanala, H. Han, R. M. Munoz, W. Browne, R. Nagle, D. D. Von Hoff, and D. J. Bearss The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer Mol. Cancer Ther., April 1, 2004; 3(4): 451 - 457. [Abstract] [Full Text] [PDF]

				A. J. Schaeffer, M. Nguyen, A. Liem, D. Lee, C. Montagna, P. F. Lambert, T. Ried, and M. J. Difilippantonio E6 and E7 Oncoproteins Induce Distinct Patterns of Chromosomal Aneuploidy in Skin Tumors from Transgenic Mice Cancer Res., January 15, 2004; 64(2): 538 - 546. [Abstract] [Full Text] [PDF]

				G. A. Pihan, J. Wallace, Y. Zhou, and S. J. Doxsey Centrosome Abnormalities and Chromosome Instability Occur Together in Pre-invasive Carcinomas Cancer Res., March 15, 2003; 63(6): 1398 - 1404. [Abstract] [Full Text] [PDF]

				D. Li, J. Zhu, P. F. Firozi, J. L. Abbruzzese, D. B. Evans, K. Cleary, H. Friess, and S. Sen Overexpression of Oncogenic STK15/BTAK/Aurora A Kinase in Human Pancreatic Cancer Clin. Cancer Res., March 1, 2003; 9(3): 991 - 997. [Abstract] [Full Text] [PDF]

				K. Neben, C. Giesecke, S. Schweizer, A. D. Ho, and A. Kramer Centrosome aberrations in acute myeloid leukemia are correlated with cytogenetic risk profile Blood, January 1, 2003; 101(1): 289 - 291. [Abstract] [Full Text] [PDF]