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Infrequent Germ-line Mutation of the E-cadherin Gene in Japanese Familial Gastric Cancer Kindreds¹

Second Department of Surgery [S. I., W. I., T. Y., Z. N., K. S.] and Department of Hygiene and Oncology [Y. A., Y. Y.], Tokyo Medical and Dental University School of Medicine, Tokyo 113-8519, and Department of Surgery, Hoshi General Hospital, Fukushima 963 [T. N.], Japan

Germ-line mutation of the E-cadherin gene was reported in familial gastric cancer (FGC) kindreds from New Zealand. Therefore, we analyzed all of the exons of E-cadherin by PCR-single-strand conformational polymorphism analysis in 16 patients from 14 Japanese FGC kindreds. However, no germ-line mutation was detected, suggesting that a predisposition to FGCs by E-cadherin gene mutation is infrequent in Japanese cases.

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