| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Molecular Oncology, Markers, Clinical Correlates |
Department of Surgery I, National Defense Medical College, Tokorozawa 359-8513, Japan
Although recent
studies have demonstrated that cyclooxygenase (COX)-2 is overexpressed
in various cancers including gastric cancer, the mechanisms underlying
the contribution of COX-2 to tumorigenesis and tumor promotion still
remain unclear. To determine the role of COX-2, we investigated the
COX-2 expression, the prostaglandin (PG) levels, and the microvessel
density in 42 patients with primary gastric adenocarcinoma. COX-2
protein was overexpressed in 31 (74%) of 42 gastric cancers based on
an immunoblot analysis. The intensity of COX-2 expression was found to
significantly correlate with lymph node involvement. The COX-2
overexpressed cases showed significantly elevated levels of
prostaglandin E2 (PGE2) in cancer
tissues in comparison with the normal gastric mucosa by an immunoassay
(201 ± 90 versus 161 ± 57 ng/mg protein;
P < 0.05). However, the COX-2 overexpression was
not related to the levels of thromboxane B2 and
6-keto-prostaglandin F1
. The density of
microvessel immunostained with CD34 was significantly higher in
patients demonstrating COX-2 overexpression than in those without such
expression (63 ± 21 versus 45 ± 17/200 x; P < 0.01). Our data thus suggested COX-2
overexpression to be associated with increased PGE2
biosynthesis and angiogenesis in gastric cancer, which indicates that
COX-2 may play a role in the development of gastric cancer.
This article has been cited by other articles:
|
|
 |
|
  J. Yokokawa, V. Cereda, C. Remondo, J. L. Gulley, P. M. Arlen, J. Schlom, and K. Y. Tsang Enhanced Functionality of CD4+CD25highFoxP3+ Regulatory T Cells in the Peripheral Blood of Patients with Prostate Cancer Clin. Cancer Res., February 15, 2008; 14(4): 1032 - 1040. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kuriki, K. Wakai, K. Matsuo, A. Hiraki, T. Suzuki, Y. Yamamura, K. Yamao, T. Nakamura, M. Tatematsu, and K. Tajima Gastric Cancer Risk and Erythrocyte Composition of Docosahexaenoic Acid with Anti-inflammatory Effects Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2406 - 2415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Hohla, A. V. Schally, K. Szepeshazi, J. L. Varga, S. Buchholz, F. Koster, E. Heinrich, G. Halmos, F. G. Rick, C. Kannadka, et al. Synergistic inhibition of growth of lung carcinomas by antagonists of growth hormone-releasing hormone in combination with docetaxel PNAS, September 26, 2006; 103(39): 14513 - 14518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Pruthi, J. E. Derksen, D. Moore, C. C. Carson, G. Grigson, C. Watkins, and E. Wallen Phase II Trial of Celecoxib in Prostate-Specific Antigen Recurrent Prostate Cancer after Definitive Radiation Therapy or Radical Prostatectomy. Clin. Cancer Res., April 1, 2006; 12(7): 2172 - 2177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D Wang and R N DuBois PROSTAGLANDINS AND CANCER Gut, January 1, 2006; 55(1): 115 - 122. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mazhar, R. Gillmore, and J. Waxman COX and cancer QJM, October 1, 2005; 98(10): 711 - 718. [Full Text] [PDF]
|
|
|
|
|
|
M.-T. Lin, C.-Y. Zuon, C.-C. Chang, S.-T. Chen, C.-P. Chen, B.-R. Lin, M.-Y. Wang, Y.-M. Jeng, K.-J. Chang, P.-H. Lee, et al. Cyr61 Induces Gastric Cancer Cell Motility/Invasion via Activation of the Integrin/Nuclear Factor-{kappa}B/Cyclooxygenase-2 Signaling Pathway Clin. Cancer Res., August 15, 2005; 11(16): 5809 - 5820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H M. Prince, L. Mileshkin, A. Roberts, V. Ganju, C. Underhill, J. Catalano, R. Bell, J. F. Seymour, D. Westerman, P. J. Simmons, et al. A Multicenter Phase II Trial of Thalidomide and Celecoxib for Patients with Relapsed and Refractory Multiple Myeloma Clin. Cancer Res., August 1, 2005; 11(15): 5504 - 5514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ito, M. Duxbury, E. Benoit, T. E. Clancy, M. J. Zinner, S. W. Ashley, and E. E. Whang Prostaglandin E2 Enhances Pancreatic Cancer Invasiveness through an Ets-1-Dependent Induction of Matrix Metalloproteinase-2 Cancer Res., October 15, 2004; 64(20): 7439 - 7446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pold, K. Krysan, A. Pold, M. Dohadwala, N. Heuze-Vourc'h, J. T. Mao, K. L. Riedl, S. Sharma, and S. M. Dubinett Cyclooxygenase-2 Modulates the Insulin-Like Growth Factor Axis in Non-Small-Cell Lung Cancer Cancer Res., September 15, 2004; 64(18): 6549 - 6555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Baldi, D Santini, F Vasaturo, M Santini, G Vicidomini, M P. Di Marino, V Esposito, A M Groeger, G Liuzzi, B Vincenzi, et al. Prognostic significance of cyclooxygenase-2 (COX-2) and expression of cell cycle inhibitors p21 and p27 in human pleural malignant mesothelioma Thorax, May 1, 2004; 59(5): 428 - 433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pold, L. X. Zhu, S. Sharma, M. D. Burdick, Y. Lin, P. P. N. Lee, A. Pold, J. Luo, K. Krysan, M. Dohadwala, et al. Cyclooxygenase-2-Dependent Expression of Angiogenic CXC Chemokines ENA-78/CXC Ligand (CXCL) 5 and Interleukin-8/CXCL8 in Human Non-Small Cell Lung Cancer Cancer Res., March 1, 2004; 64(5): 1853 - 1860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P J Hu, J Yu, Z R Zeng, W K Leung, H L Lin, B D Tang, A H C Bai, and J J Y Sung Chemoprevention of gastric cancer by celecoxib in rats Gut, February 1, 2004; 53(2): 195 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Dohadwala, R. K. Batra, J. Luo, Y. Lin, K. Krysan, M. Pold, S. Sharma, and S. M. Dubinett Autocrine/Paracrine Prostaglandin E2 Production by Non-small Cell Lung Cancer Cells Regulates Matrix Metalloproteinase-2 and CD44 in Cyclooxygenase-2-dependent Invasion J. Biol. Chem., December 20, 2002; 277(52): 50828 - 50833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Kisley, B. S. Barrett, L. D. Dwyer-Nield, A. K. Bauer, D. C. Thompson, and A. M. Malkinson Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice Carcinogenesis, October 1, 2002; 23(10): 1653 - 1660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Costa, R Soares, J S Reis-Filho, D Leitao, I Amendoeira, and F C Schmitt Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer J. Clin. Pathol., June 1, 2002; 55(6): 429 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Edwards, S. P. Faux, S. M. Plummer, K. R. Abrams, R. A. Walker, D. A. Waller, and K. J. O'Byrne Cyclooxygenase-2 Expression Is a Novel Prognostic Factor in Malignant Mesothelioma Clin. Cancer Res., June 1, 2002; 8(6): 1857 - 1862. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Davies, L.-A. Martin, N. Sacks, and M. Dowsett Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemoprevention Ann. Onc., May 1, 2002; 13(5): 669 - 678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Wallace Nutritional and Botanical Modulation of the Inflammatory Cascade--Eicosanoids, Cyclooxygenases, and Lipoxygenases-- As an Adjunct in Cancer Therapy Integr Cancer Ther, March 1, 2002; 1(1): 7 - 37. [Abstract] [PDF]
|
|
|
|
|
|
K. Saukkonen, O. Nieminen, B. van Rees, S. Vilkki, M. Harkonen, M. Juhola, J.-P. Mecklin, P. Sipponen, and A. Ristimaki Expression of Cyclooxygenase-2 in Dysplasia of the Stomach and in Intestinal-type Gastric Adenocarcinoma Clin. Cancer Res., July 1, 2001; 7(7): 1923 - 1931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shono, P. J. Tofilon, J. M. Bruner, O. Owolabi, and F. F. Lang Cyclooxygenase-2 Expression in Human Gliomas: Prognostic Significance and Molecular Correlations Cancer Res., June 1, 2001; 61(11): 4375 - 4381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hyun Song, H.-S. Jong, H. H. Choi, H. Inoue, T. Tanabe, N. K. Kim, and Y.-J. Bang Transcriptional Silencing of Cyclooxygenase-2 by Hyper-methylation of the 5' CpG Island in Human Gastric Carcinoma Cells Cancer Res., June 1, 2001; 61(11): 4628 - 4635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Md. A. Rahman, D. K. Dhar, E. Yamaguchi, S. Maruyama, T. Sato, H. Hayashi, T. Ono, A. Yamanoi, H. Kohno, and N. Nagasue Coexpression of Inducible Nitric Oxide Synthase and COX-2 in Hepatocellular Carcinoma and Surrounding Liver: Possible Involvement of COX-2 in the Angiogenesis of Hepatitis C Virus-positive Cases Clin. Cancer Res., May 1, 2001; 7(5): 1325 - 1332. [Abstract] [Full Text]
|
|
|
|
|
|
M. Akhtar, Y. Cheng, R. M. Magno, H. Ashktorab, D. T. Smoot, S. J. Meltzer, and K. T. Wilson Promoter Methylation Regulates Helicobacter pylori-stimulated Cyclooxygenase-2 Expression in Gastric Epithelial Cells Cancer Res., March 1, 2001; 61(6): 2399 - 2403. [Abstract] [Full Text]
|
|
|
|
|
|
M. Richter, M. Weiss, I. Weinberger, G. Furstenberger, and B. Marian Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors Carcinogenesis, January 1, 2001; 22(1): 17 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Williams, A. J. M. Watson, H. Sheng, R. Helou, J. Shao, and R. N. DuBois Celecoxib Prevents Tumor Growth in Vivo without Toxicity to Normal Gut: Lack of Correlation between in Vitro and in Vivo Models Cancer Res., November 1, 2000; 60(21): 6045 - 6051. [Abstract] [Full Text]
|
|
|
|
|
|
R. Masunaga, H. Kohno, D. K. Dhar, S. Ohno, M. Shibakita, S. Kinugasa, H. Yoshimura, M. Tachibana, H. Kubota, and N. Nagasue Cyclooxygenase-2 Expression Correlates with Tumor Neovascularization and Prognosis in Human Colorectal Carcinoma Patients Clin. Cancer Res., October 1, 2000; 6(10): 4064 - 4068. [Abstract] [Full Text]
|
|
|
|
 |
|
 F. A. Wollheim Selective Cox-2 inhibition in man--therapeutic breakthrough or cosmetic advance? Rheumatology, September 1, 2000; 39(9): 935 - 938. [Full Text] [PDF]
|
|
|
|
|
|
M. Dohadwala, J. Luo, L. Zhu, Y. Lin, G. J. Dougherty, S. Sharma, M. Huang, M. Pold, R. K. Batra, and S. M. Dubinett Non-small Cell Lung Cancer Cyclooxygenase-2-dependent Invasion Is Mediated by CD44 J. Biol. Chem., June 8, 2001; 276(24): 20809 - 20812. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
