This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Amato, R. J. Articles by Pollack, A. Search for Related Content PubMed PubMed Citation Articles by Amato, R. J. Articles by Pollack, A.

Cyclophosphamide and Carboplatin and Selective Consolidation in Advanced Seminoma

Departments of Genitourinary Medical Oncology [R. J. A., R. M., D. D., L. W., C. L.] and Radiation Oncology [A. P.], The University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030

This prospective Phase II study assesses the clinical efficacy and complications of a treatment regimen of combination chemotherapy with cyclophosphamide and carboplatin and selective consolidation in advanced seminoma. Of 46 patients who entered the study between December 1992 and October 1998, 46 were evaluable. Thirty-two achieved a complete remission (70%; 95% confidence interval, 56–83%) after chemotherapy alone. Fourteen achieved a complete remission (30%; 95% confidence interval, 18–46%) after chemotherapy plus consolidation. Forty-three of the 46 patients (93%; 95% confidence interval, 82–97%) remained in remission after a median follow-up period of 27.4 months. No patient experienced nephrotoxic, neurotoxic, or ototoxic effects or hemorrhagic cystitis. No patient had neutropenic fever requiring hospitalization. Thirteen % required platelet transfusions, and 9% required transfusions of packed RBCs. For patients with advanced seminoma, treatment with cyclophosphamide and carboplatin and selective consolidation is safe and effective.