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Molecular Oncology, Markers, Clinical Correlates |
Second Department of Surgery, Shimane Medical University, Izymo 693-8501, Japan
The role of
cyclooxygenase-2 (COX-2) in tumor neovascularization of human
colorectal carcinoma is yet to be delineated. One hundred colorectal
carcinoma specimens were evaluated for COX-2 expression and
CD34-stained microvessel density (MVD) by immunohistochemical methods.
The relationships between COX-2 expression and clinicopathological
feature of the patients, MVD, and survival time were analyzed.
Increased COX-2 expression was significantly correlated with
pathologically unfavorable findings such as tumor size (>3.0 cm),
tumor differentiation (poor, moderate > well
differentiated), number of metastatic lymph nodes (
4), and Dukes’
stage (Dukes’ B, C, and D). Larger number of microvessels congregated
around the COX-2-expressing area, and the Spearman rank correlation
test showed a strong correlation between COX-2 expression and tumor MVD
(P < 0.0001). Patients with COX-2-positive tumors
had a significantly (P = 0.037, by log-rank test)
shorter survival time than those with negative tumors did. In the
multivariate analysis, however, only Dukes’ stage and number of
metastatic lymph nodes remained as independent prognostic factors.
Augmented tumor neovascularization may be one of the several effects of
COX-2 responsible for poor prognosis in human colorectal carcinoma
patients.
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