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Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157 [A. E. F.], and Laboratory of Molecular Biology [R. J. K.] and Developmental Therapeutics Program, Clinical Trials Unit, Medicine Branch [E. A. S.], National Cancer Institute, NIH, Bethesda, Maryland 20892-7458
Targeted toxins, consisting of tumor-selective ligands coupled to polypeptide toxins, represent a new class of cancer therapeutics that kills malignant cells by inactivating cytosolic protein synthesis and inducing apoptosis. A number of these molecules have been produced under good manufacturing practice conditions and given systemically to patients with a variety of neoplasms. The promising results to date and the remaining pharmacological hurdles are discussed.
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