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Clinical Cancer Research Vol. 6, 1073-1078, March 2000
© 2000 American Association for Cancer Research

Molecular Oncology, Markers, Clinical Correlates

DNA-dependent Protein Kinase Activity Correlates with Ku70 Expression and Radiation Sensitivity in Esophageal Cancer Cell Lines1

Heng-Jiang Zhao, Yoshio Hosoi2, Hideo Miyachi, Keiichiro Ishii, Masayuki Yoshida, Kenji Nemoto, Yoshihiro Takai, Shogo Yamada, Norio Suzuki and Tetsuya Ono

Departments of Radiation Research [H-J. Z., Y. H., K. I., M. Y., T. O.] and Radiology [H. M., K. N., Y. T., S. Y.], Tohoku University School of Medicine, Sendai 980-8575, Japan, and Department of Radiation Oncology, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan [Y. H., N. S.]

We investigated the relationship between DNA-dependent protein kinase (DNA-PK) activity and radiation sensitivity using 14 esophageal cancer cell lines, TE 1–14. DNA-PK activities differed significantly among the cell lines. The highest DNA-PK activity observed in TE-8 was more than two times higher than the lowest DNA-PK activity observed in TE-5. Significant correlation was observed between DNA-PK activity and D0 (r = 0.766; P = 0.0008). Western blots analysis revealed a significant correlation between DNA-PK activity and Ku70 expression, suggesting that the regulation in DNA-PK activity was associated with Ku70 expression. The data suggest that the measurement of DNA-PK activity and/or Ku70 expression may provide a useful way to predict radiation sensitivity.




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Copyright © 2000 by the American Association for Cancer Research.