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Molecular Oncology, Markers, Clinical Correlates |
Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu 874-0838 [K. Y., M. M., T. S., K. S.], and Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka [K. S.], Japan
Matrix
metalloproteinase-7 (MMP-7) is a member of MMP family and has a wide
variety of substrate spectra. It is reported to play an important role
in carcinoma invasion and metastasis. There is, however, little
information on the clinical significance of MMP-7 in human esophageal
carcinoma. We thus studied 48 tumor/normal pair samples of human
esophagus by Northern blot analysis. The results demonstrated that the
tumor tissue (T) of esophageal carcinoma showed a higher expression of
MMP-7 mRNA than the corresponding normal tissue (N) in 31 cases (65%).
We also statistically evaluated tumor MMP-7 value (T value) corrected
for MMP-7-positive control (KYSE150 transfected with the
MMP-7 gene). Fourteen cases with T value 
0.3 showed a higher frequency of lymph node metastasis than 34 cases
with T value < 0.3 (P < 0.05). The cases
with T value 0.3 showed a significantly poorer prognosis than
those with T value < 0.3 (P < 0.01).
Multivariate analysis demonstrated that the MMP-7 expression status was
the independent factor relating to the prognosis (P = 0.0005). The findings indicated that MMP-7 might be a novel
prognostic factor for patients with esophageal carcinoma.
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