| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Clinical Trials |
Our Lady Of Mercy Medical Center-Comprehensive Cancer Center, New York Medical College, Bronx, New York 10466-4002
DNA sequences with very high similarity (95–98%) to the mouse mammary tumor virus (MMTV) ENV gene have been amplified by PCR in 38.5% of human breast tumors and in <2% of normal breast tissue (Wang et al., Cancer Res., 55: 5173–5179, 1995). Intrigued by these findings, which suggested an exogenous viral etiology for a certain percentage of human breast tumors, we have screened a panel of human breast tumors and normal breast tissue for the presence of MMTV-like DNA sequences. Using similar PCR procedures and stringent hybridization techniques, we have detected the presence of MMTV-like ENV gene sequences in 37% of the human breast tumors that we have analyzed. DNA sequencing has shown these sequences to be 99% homologous to the BR6 strain of MMTV and 100% homologous to the GR and C3H strains of MMTV. We have not detected these MMTV-like sequences in normal breast tissue. However, we have detected these sequences by PCR and stringent hybridization in a T-cell lymphoma of a breast cancer patient who was simultaneously diagnosed with both diseases. Our results support the possibility of an exogenous retroviral etiology for a certain percentage of human breast tumors. Our results also suggest that a similar exogenous retroviral etiology may exist for certain human T-cell lymphomas. In many inbred strains of mice, both breast cancer and T-cell lymphoma are caused by MMTV, hence, in a certain percentage of humans, one or both of these diseases may be caused by an MMTV-like retroviral entity.
This article has been cited by other articles:
|
|
 |
|
  J. E Morabito, J. F Trott, D. M Korz, H. E Fairfield, S. H Buck, and R. C Hovey A 5' distal palindrome within the mouse mammary tumor virus-long terminal repeat recruits a mammary gland-specific complex and is required for a synergistic response to progesterone plus prolactin J. Mol. Endocrinol., August 1, 2008; 41(2): 75 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Voisset, R. A. Weiss, and D. J. Griffiths Human RNA "Rumor" Viruses: the Search for Novel Human Retroviruses in Chronic Disease Microbiol. Mol. Biol. Rev., March 1, 2008; 72(1): 157 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Frank, C. Verbeke, N. Schwarz, J. Mayer, A. Fabarius, R. Hehlmann, C. Leib-Mosch, and W. Seifarth Variable Transcriptional Activity of Endogenous Retroviruses in Human Breast Cancer J. Virol., February 15, 2008; 82(4): 1808 - 1818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Melana, I. Nepomnaschy, M. Sakalian, A. Abbott, J. Hasa, J. F. Holland, and B. G.T. Pogo Characterization of Viral Particles Isolated from Primary Cultures of Human Breast Cancer Cells Cancer Res., September 15, 2007; 67(18): 8960 - 8965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bindra, S. Muradrasoli, R. Kisekka, H. Nordgren, F. Warnberg, and J. Blomberg Search for DNA of exogenous mouse mammary tumor virus-related virus in human breast cancer samples J. Gen. Virol., June 1, 2007; 88(6): 1806 - 1809. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J S Lawson, D D Tran, E Carpenter, C E Ford, W D Rawlinson, N J Whitaker, and W Delprado Presence of mouse mammary tumour-like virus gene sequences may be associated with morphology of specific human breast cancer J. Clin. Pathol., December 1, 2006; 59(12): 1287 - 1292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bar-Sinai, N. Bassa, M. Fischette, M. M. Gottesman, D. C. Love, J. A. Hanover, and J. Hochman Mouse Mammary Tumor Virus Env-Derived Peptide Associates with Nucleolar Targets in Lymphoma, Mammary Carcinoma, and Human Breast Cancer Cancer Res., August 15, 2005; 65(16): 7223 - 7230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Indik, W. H. Gunzburg, B. Salmons, and F. Rouault Mouse Mammary Tumor Virus Infects Human Cells Cancer Res., August 1, 2005; 65(15): 6651 - 6659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Mant, J. Cason, B. G.T. Pogo, and J. F. Holland Mouse Mammary Tumor Virus and Human Breast Cancer Cancer Res., February 1, 2005; 65(3): 1112 - 1113. [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Ford, M. Faedo, and W. D. Rawlinson Mouse Mammary Tumor Virus-like RNA Transcripts and DNA Are Found in Affected Cells of Human Breast Cancer Clin. Cancer Res., November 1, 2004; 10(21): 7284 - 7289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Holland and B. G. T. Pogo Mouse Mammary Tumor Virus-Like Viral Infection and Human Breast Cancer Clin. Cancer Res., September 1, 2004; 10(17): 5647 - 5649. [Full Text] [PDF]
|
|
|
|
|
|
P. R. Etkind, A. F. R. Stewart, T. Dorai, D. J. Purcell, and P. H. Wiernik Clonal Isolation of Different Strains of Mouse Mammary Tumor Virus-Like DNA Sequences from Both the Breast Tumors and Non-Hodgkin's Lymphomas of Individual Patients Diagnosed with Both Malignancies Clin. Cancer Res., September 1, 2004; 10(17): 5656 - 5664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Ford, M. Faedo, R. Crouch, J. S. Lawson, and W. D. Rawlinson Progression from Normal Breast Pathology to Breast Cancer Is Associated with Increasing Prevalence of Mouse Mammary Tumor Virus-Like Sequences in Men and Women Cancer Res., July 15, 2004; 64(14): 4755 - 4759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Faedo, C. E. Ford, R. Mehta, K. Blazek, and W. D. Rawlinson Mouse Mammary Tumor-Like Virus Is Associated with p53 Nuclear Accumulation and Progesterone Receptor Positivity but not Estrogen Positivity in Human Female Breast Cancer Clin. Cancer Res., July 1, 2004; 10(13): 4417 - 4419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, J.-D. Jiang, D. Xu, Y. Li, C. Qu, J. F. Holland, and B. G-T. Pogo A Mouse Mammary Tumor Virus-Like Long Terminal Repeat Superantigen in Human Breast Cancer Cancer Res., June 15, 2004; 64(12): 4105 - 4111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, J. C. Rassa, M. E. deObaldia, L. M. Albritton, and S. R. Ross Identification of the Receptor Binding Domain of the Mouse Mammary Tumor Virus Envelope Protein J. Virol., October 1, 2003; 77(19): 10468 - 10478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F J Hoar, S-Y Chan, P S Stonelake, R W Wolverson, and D Bareford Splenic rupture as a consequence of dual malignant pathology: a case report J. Clin. Pathol., September 1, 2003; 56(9): 709 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Ford, D. Tran, Y. Deng, V. T. Ta, W. D. Rawlinson, and J. S. Lawson Mouse Mammary Tumor Virus-like Gene Sequences in Breast Tumors of Australian and Vietnamese Women Clin. Cancer Res., March 1, 2003; 9(3): 1118 - 1120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yamazaki, E. A. Boyse, J. Bard, M. Curran, D. Kim, S. R. Ross, and G. K. Beauchamp Presence of mouse mammary tumor virus specifically alters the body odor of mice PNAS, April 16, 2002; 99(8): 5612 - 5615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Liu, Y. Wang, S. M. Melana, I. Pelisson, V. Najfeld, J. F. Holland, and B. G-T. Pogo Identification of a Proviral Structure in Human Breast Cancer Cancer Res., February 1, 2001; 61(4): 1754 - 1759. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Melana, J. F. Holland, and B. G-T. Pogo Search for Mouse Mammary Tumor Virus-like env Sequences in Cancer and Normal Breast from the Same Individuals Clin. Cancer Res., February 1, 2001; 7(2): 283 - 284. [Abstract] [Full Text]
|
|
|
|
|
|
K. Yamazaki, E. A. Boyse, J. Bard, M. Curran, D. Kim, S. R. Ross, and G. K. Beauchamp Presence of mouse mammary tumor virus specifically alters the body odor of mice PNAS, April 16, 2002; 99(8): 5612 - 5615. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
