This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tibiletti, M. G. Articles by Taramelli, R. Search for Related Content PubMed PubMed Citation Articles by Tibiletti, M. G. Articles by Taramelli, R.

A Large 6q Deletion Is a Common Cytogenetic Alteration in Fibroadenomas, Pre-malignant Lesions, and Carcinomas of the Breast¹

Department of Pathology, Ospedale di Circolo, Varese, Italy [M. G. T., B. Be., R. C., B. Br.], and Departments of Clinical Biological Sciences [F. S., D. F., C. C.] and Structural and Functional Biology [F. A., M. B., A. R., R. T.], University of Insubria, 21100 Varese, Italy

To assess whether early breast lesions are the precursors of invasive carcinomas, three classes of breast lesions, namely benign tumors (including fibroadenomas), putative premalignant lesions (including cases of atypical hyperplasia), and invasive carcinomas, were compared at the cytogenetic and molecular cytogenetic levels. Genetic relatedness was clearly demonstrated by the sharing of several anomalies, among which 6q deletions outnumbered all of the other alterations detected. Indeed, deletions of the long arm of chromosome 6, most likely occurring in epithelial cells, were present in 83.9% of benign breast tumors, 64% of putative premalignant lesions, and 77.4% of analyzable carcinomas. Furthermore, the interval between 6q24 and qter appeared to be the common region of deletion in all three classes of breast lesions, whereas the minimal common region of deletion was 6q27-qter. Interestingly, the latter region was reported previously to be deleted in benign ovarian tumors and recently found to harbor a gene (SEN6) that is important for SV40-mediated immortalization of human cells.

This article has been cited by other articles:

				Z. Jin, J. P. Hamilton, J. Yang, Y. Mori, A. Olaru, F. Sato, T. Ito, T. Kan, Y. Cheng, B. Paun, et al. Hypermethylation of the AKAP12 Promoter is a Biomarker of Barrett's-Associated Esophageal Neoplastic Progression Cancer Epidemiol. Biomarkers Prev., January 1, 2008; 17(1): 111 - 117. [Abstract] [Full Text] [PDF]

				D. L. Ellsworth, R. E. Ellsworth, B. Love, B. Deyarmin, S. M. Lubert, V. Mittal, J. A. Hooke, and C. D. Shriver Outer Breast Quadrants Demonstrate Increased Levels of Genomic Instability Ann. Surg. Oncol., September 1, 2004; 11(9): 861 - 868. [Abstract] [Full Text] [PDF]

				N. Franco, L. Arnould, F. Mege, S.-F. Picard, P. Arveux, and S. Lizard-Nacol Comparative Analysis of Molecular Alterations in Fibroadenomas Associated or Not With Breast Cancer Arch Surg, March 1, 2003; 138(3): 291 - 295. [Abstract] [Full Text] [PDF]

				E. Tan-Chiu, J. Wang, J. P. Costantino, S. Paik, C. Butch, D. L. Wickerham, B. Fisher, and N. Wolmark Effects of Tamoxifen on Benign Breast Disease in Women at High Risk for Breast Cancer J Natl Cancer Inst, February 19, 2003; 95(4): 302 - 307. [Abstract] [Full Text] [PDF]

				Z. Li, Z. H. Meng, A. Sayeed, R. Shalaby, B.-M. Ljung, and S. H. Dairkee Genome-wide Allelotyping of a New in Vitro Model System Reveals Early Events in Breast Cancer Progression Cancer Res., October 15, 2002; 62(20): 5980 - 5987. [Abstract] [Full Text] [PDF]

				N. Franco, S.-F. Picard, F. Mege, L. Arnould, and S. Lizard-Nacol Absence of Genetic Abnormalities in Fibroadenomas of the Breast Determined at p53 Gene Mutations and Microsatellite Alterations Cancer Res., November 1, 2001; 61(21): 7955 - 7958. [Abstract] [Full Text] [PDF]