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Clinical Cancer Research Vol. 6, 1536-1545, April 2000
© 2000 American Association for Cancer Research

Experimental Therapeutics, Preclinical Pharmacology

Apoptosis-inducing Vanadocene Compounds against Human Testicular Cancer

Phalguni Ghosh, Osmond J. D’Cruz, Rama Krishna Narla and Fatih M. Uckun1

Drug Discovery Program [P. G., O. J. D., R. K. N., F. M. U.], Parker Hughes Cancer Center [P. G., O. J. D., R. K. N., F. M. U.], and Departments of Chemistry [P. G.] and Experimental Oncology [O. J. D., R. K. N., F. M. U.], Parker Hughes Institute, St. Paul, Minnesota 55113

We systematically assessed the cytotoxic effects of five metallocene dichlorides containing vanadium (vanadocene dichloride), titanium (titanocene dichloride), zirconium (zircodocene dichloride), molybdenum (molybdocene dichloride), and hafnium (hafnocene dichloride) as the central metal atom and 19 other vanadocene complexes. These compounds were tested against the human testicular cancer cell lines Tera-2 and Ntera-2 using both 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays and apoptosis assays. Notably, only the vanadium(IV)-containing metallocenes exhibited significant cytotoxicity against Tera-2 and Ntera-2 cells and induced apoptosis within 24 h. Vanadocenes with dithiocyanate [VCp2(SCN)2·0.5 H2O] and diselenocyanate [VCp2(NCSe)2] as ancillary ligands were identified as the most potent cytotoxic compounds. Vanadocenes, especially the lead compound VCp2(NCSe)2, may be useful in the treatment of testicular cancer.




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O. J. D'Cruz and F. M. Uckun
Preclinical Evaluation of a Dual-Acting Microbicidal Prodrug WHI-07 in Combination with Vanadocene Dithiocarbamate in the Female Reproductive Tract of Rabbit, Pig, and Cat
Toxicol Pathol, December 1, 2007; 35(7): 910 - 927.
[Abstract] [Full Text] [PDF]


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Copyright © 2000 by the American Association for Cancer Research.