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Molecular Oncology, Markers, Clinical Correlates |
Department of Surgical Oncology [K. M., M. K., O. I., T. K., Y. S., M. H., H. O., S. Im.], and Department of Pathology [S. Is.], Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari, Osaka 537-8511; Department of Biochemistry [E. M., N. T.], Osaka University Medical School, Suita, Osaka 565-0871; and Diagnostic Research Laboratories, Fuji Rebio Inc. [S. It., H. H., F. T.], Hachioji, Tokyo 192-0031, Japan
N-Acetylglucosaminyltransferase
V (GnT-V) is an enzyme that catalyzes ß 1–6 branching of
N-acetylglucosamine on asparagine-linked
oligosaccharides of cell proteins. Metastatic potential of various
cancer cells has been shown to correlate with increase of GnT-V
activity and concomitant ß 1–6 branching of
N-acetylglucosamine. However, protein expression of
GnT-V in human cancer tissue and its clinical significance have not yet
been demonstrated. To clarify the possible relationship between
metastasis and GnT-V in human colorectal cancer, protein expression of
GnT-V was studied using surgically resected specimens. We established a
monoclonal antibody against GnT-V and performed immunohistochemical
analysis of 103 human colorectal cancer cases. Of 103 cases, 26 cases
(25.2%) showed specific expression of GnT-V in colorectal cancer
tissues. The expression of GnT-V was significantly correlated with
distant metastasis (P < 0.05, 
2
test). Overall 5-year survival rate was 52.8% for GnT-V–positive
patients and 81.7% for GnT-V–negative patients (P < 0.01, Log-rank test). We showed direct evidence for the relationship
between GnT-V and metastasis in human colorectal cancer. Screening of
GnT-V expression in colorectal cancer may provide useful information
for prognosis of postoperative patients.
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