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Clinical Cancer Research Vol. 6, 1896-1899, May 2000
© 2000 American Association for Cancer Research

Molecular Oncology, Markers, Clinical Correlates

The Cell Cycle Inhibitors p21WAF1 and p27KIP1 Are Associated with Survival in Patients Treated by Salvage Prostatectomy after Radiation Therapy1

Liang Cheng2, Ricardo V. Lloyd, Amy L. Weaver, Thomas M. Pisansky, John C. Cheville, Dharamdas M. Ramnani, Bradley C. Leibovich, Michael L. Blute, Horst Zincke and David G. Bostwick3

Departments of Pathology [L. C.] and Urology [L. C.], Indiana University School of Medicine, Indianapolis, Indiana 46202; Department of Pathology [R. V. L., J. C. C., D. M. R., D. G. B.], Section of Biostatistics [A. L. W.], Division of Radiation Oncology [T. M. P.], and Department of Urology [B. C. L., M. L. B., H. Z., D. G. B.], Mayo Clinic & Mayo Foundation, Rochester, Minnesota 55905

We evaluated p27KIP1 and p21WAF1 expression in 52 patients treated by salvage radical prostatectomy and bilateral pelvic lymphadenectomy for biopsy-proven locally persistent or recurrent prostate cancer after external beam radiation therapy. We defined low and high expression based on the median value observed in our sample. Five-year distant metastasis-free survival and cancer-specific survival were 71 and 82%, respectively, for patients with low expression of p21 (<=5%), compared with 94 and 100%, respectively, for those with high expression of p21 (>5%; P = 0.02 and 0.01, respectively). Five-year distant metastasis-free survival and cancer-specific survival were 71 and 82%, respectively, for patients with low expression of p27 (<50%), compared with 88 and 96%, respectively, for those with high expression of p27 (>=50%; P = 0.06 and 0.01, respectively). These findings indicate that p21 and p27 expression levels are significant predictors of survival for patients selected for salvage prostatectomy for recurrent prostate cancer.




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Copyright © 2000 by the American Association for Cancer Research.