This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chow, N.-H. Articles by Chan, S.-H. Search for Related Content PubMed PubMed Citation Articles by Chow, N.-H. Articles by Chan, S.-H.

The Role of nm23-H1 in the Progression of Transitional Cell Bladder Cancer¹

Departments of Pathology [N-H. C.] and Microbiology and Immunology [H-S. L.], College of Medicine, and Department of Statistics [S-H. C.], National Cheng Kung University, Tainan 70428, Taiwan, Republic of China

The nm23 gene was initially cloned as a metastasis suppressor gene, but the clinical relevance of nm23-H1 as a metastasis suppressor or prognostic indicator for human cancers remains enigmatic. Given that gene expression is regulated at the tissue-specific level, we studied the molecular mechanisms of nm23-H1 expression in human bladder cancer cell lines and the clinical importance of protein product (NM23-H1) in association with patient outcome (n = 257) by immunohistochemistry. We demonstrated that nm23-H1 is expressed in bladder cancer cells without genomic alterations. High NM23-H1 expression was found in 39 cases (15.2%), intermediate expression in 119 cases (46.3%), and low NM23-H1 in 99 cases (38.5%). NM23-H1 was inversely related to staging classification or tumor size (P < 0.05), with the most significant difference being observed between pT_a tumors and those of pT₁-pT₃ bladder cancer (P = 0.01). Reduced NM23-H1, defined as intermediate and low levels of expression, tended to have a higher risk of tumor metastasis (P = 0.06) or poor longtime survival (P = 0.07). In the subset of grade 2 bladder tumors, reduced NM23-H1 significantly correlated with the occurrence of tumor metastasis or poor patient survival (P < 0.05). These findings overall suggest that nm23-H1 may play an important role in suppressing the early step of carcinogenesis and thus act as an invasion suppressor for human bladder cancer. A prospective study is required to clarify the potential of the molecular marker in prediction of disease progression.

This article has been cited by other articles:

				E. J. Chapman, G. Kelly, and M. A. Knowles Genes Involved in Differentiation, Stem Cell Renewal, and Tumorigenesis Are Modulated in Telomerase-Immortalized Human Urothelial Cells Mol. Cancer Res., July 1, 2008; 6(7): 1154 - 1168. [Abstract] [Full Text] [PDF]

				P. Mhawech-Fauceglia, P. Dulguerov, A. Beck, M. Bonet, and A. S Allal Value of ezrin, maspin and nm23-H1 protein expressions in predicting outcome of patients with head and neck squamous-cell carcinoma treated with radical radiotherapy J. Clin. Pathol., February 1, 2007; 60(2): 185 - 189. [Abstract] [Full Text] [PDF]

				H.-L. Cheng, B. Trink, T.-S. Tzai, H.-S. Liu, S.-H. Chan, C.-L. Ho, D. Sidransky, and N.-H. Chow Overexpression of c-met as a Prognostic Indicator for Transitional Cell Carcinoma of the Urinary Bladder: A Comparison With p53 Nuclear Accumulation J. Clin. Oncol., March 15, 2002; 20(6): 1544 - 1550. [Abstract] [Full Text] [PDF]