Clinical Cancer Research Meeting Calendar Advances in Breast Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kulkarni, S.
Right arrow Articles by Dannenberg, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kulkarni, S.
Right arrow Articles by Dannenberg, A. J.
Clinical Cancer Research Vol. 7, 429-434, February 2001
© 2001 American Association for Cancer Research

Cancer Biology, Immunology, Cytokines

Cyclooxygenase-2 Is Overexpressed in Human Cervical Cancer1

Swati Kulkarni, Janet S. Rader, Fan Zhang, Helen Liapis, Alane T. Koki, Jaime L. Masferrer, Kotha Subbaramaiah and Andrew J. Dannenberg2

Departments of Medicine [K. S., A. J. D.] and Surgery [S. K.], New York Presbyterian Hospital-Cornell, New York, New York 10021; Strang Cancer Prevention Center, New York, New York 10021 [F. Z., K. S., A. J. D.]; Departments of Obstetrics and Gynecology [J. S. R.] and Pathology [H. L.], Washington University School of Medicine, St. Louis, Missouri 63110; and Searle Discovery Research, Pharmacia, St. Louis, Missouri 63017 [A. T. K., J. L. M.]

Multiple lines of evidence suggest that cyclooxygenase-2 (COX-2) is an important target for preventing epithelial malignancies. Little is known, however, about the expression of COX-2 in gynecological malignancies. By immunoblot analysis, COX-2 was detected in 12 of 13 cases of cervical cancer but was undetectable in normal cervical tissue. Immunohistochemistry revealed COX-2 in malignant epithelial cells. COX-2 was also expressed in cervical intraepithelial neoplasia. The mechanism by which COX-2 is up-regulated in cervical cancer is unknown. Because the epidermal growth factor (EGF) receptor is commonly overexpressed in cervical cancer, we investigated whether EGF could induce COX-2 in cultured human cervical carcinoma cells. Treatment with EGF markedly induced COX-2 protein, COX-2 mRNA, and stimulated COX-2 promoter activity. The induction of COX-2 by EGF was suppressed by inhibitors of tyrosine kinase activity, phosphatidylinositol 3-kinase, mitogen-activated protein kinase kinase, and p38 mitogen-activated protein kinase. Moreover, overexpressing dominant-negative forms of extracellular signal-regulated kinase 1, c-Jun NH2-terminal kinase, p38, and c-Jun blocked EGF-mediated induction of COX-2 promoter activity. Taken together, these findings suggest that deregulation of the EGF receptor signaling pathway may lead to enhanced COX-2 expression in cervical cancer.




This article has been cited by other articles:


Home page
 CarcinogenesisHome page
S.-H. Kim, J.-M. Oh, J.-H. No, Y.-J. Bang, Y.-S. Juhnn, and Y.-S. Song
Involvement of NF-{kappa}B and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein
Carcinogenesis, May 1, 2009; 30(5): 753 - 757.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K.-Y. Chang, M.-R. Shen, M.-Y. Lee, W.-L. Wang, W.-C. Su, W.-C. Chang, and B.-K. Chen
Epidermal Growth Factor-activated Aryl Hydrocarbon Receptor Nuclear Translocator/HIF-1{beta} Signal Pathway Up-regulates Cyclooxygenase-2 Gene Expression Associated with Squamous Cell Carcinoma
J. Biol. Chem., April 10, 2009; 284(15): 9908 - 9916.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. M. Bock, S. G. Menon, L. L. Sinclair, N. S. Bedford, P. C. Goswami, F. E. Domann, and D. K. Trask
Celecoxib Toxicity Is Cell Cycle Phase Specific
Cancer Res., April 15, 2007; 67(8): 3801 - 3808.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Subbaramaiah and A. J. Dannenberg
Cyclooxygenase-2 Transcription Is Regulated by Human Papillomavirus 16 E6 and E7 Oncoproteins: Evidence of a Corepressor/Coactivator Exchange
Cancer Res., April 15, 2007; 67(8): 3976 - 3985.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
A. Jimeno, M. L. Amador, P. Kulesza, X. Wang, B. Rubio-Viqueira, X. Zhang, A. Chan, J. Wheelhouse, H. Kuramochi, K. Tanaka, et al.
Assessment of celecoxib pharmacodynamics in pancreatic cancer
Mol. Cancer Ther., December 1, 2006; 5(12): 3240 - 3247.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. M. Monjazeb, K. P. High, A. Connoy, L. S. Hart, C. Koumenis, and F. H. Chilton
Arachidonic acid-induced gene expression in colon cancer cells
Carcinogenesis, October 1, 2006; 27(10): 1950 - 1960.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
K. J. Auborn
Can Indole-3-Carbinol-Induced Changes in Cervical Intraepithelial Neoplasia Be Extrapolated to Other Food Components?
J. Nutr., October 1, 2006; 136(10): 2676S - 2678S.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Muller, K. J. Sales, A. A. Katz, and H. N. Jabbour
Seminal Plasma Promotes the Expression of Tumorigenic and Angiogenic Genes in Cervical Adenocarcinoma Cells via the E-Series Prostanoid 4 Receptor
Endocrinology, July 1, 2006; 147(7): 3356 - 3365.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
S. Grosch, T. J. Maier, S. Schiffmann, and G. Geisslinger
Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors.
J Natl Cancer Inst, June 7, 2006; 98(11): 736 - 747.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J.-M. Wang, C.-Y. Ko, L.-C. Chen, W.-L. Wang, and W.-C. Chang
Functional role of NF-IL6{beta} and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene
Nucleic Acids Res., January 5, 2006; 34(1): 217 - 231.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. N. Jabbour, K. J. Sales, S. C. Boddy, R. A. Anderson, and A. R. W. Williams
A Positive Feedback Loop that Regulates Cyclooxygenase-2 Expression and Prostaglandin F2{alpha} Synthesis via the F-Series-Prostanoid Receptor and Extracellular Signal-Regulated Kinase 1/2 Signaling Pathway
Endocrinology, November 1, 2005; 146(11): 4657 - 4664.
[Abstract] [Full Text] [PDF]

Home page
 CLIN APPL THROMB HEMOSTHome page
S. Kanazawa, K. Yamaguchi, Y. Kinoshita, M. Muramatsu, Y. Komiyama, and S. Nomura
Gefitinib Affects Functions of Platelets and Blood Vesselsvia Changes in Prostanoids Balance
Clinical and Applied Thrombosis/Hemostasis, October 1, 2005; 11(4): 429 - 434.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
V. Marwaha, Y.-H. Chen, E. Helms, S. Arad, H. Inoue, E. Bord, R. Kishore, R. D. Sarkissian, B. A. Gilchrest, and D. A. Goukassian
T-oligo Treatment Decreases Constitutive and UVB-induced COX-2 Levels through p53- and NF{kappa}B-dependent Repression of the COX-2 Promoter
J. Biol. Chem., September 16, 2005; 280(37): 32379 - 32388.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. Wu, A. L. Abramson, M. J. Shikowitz, A. J. Dannenberg, and B. M. Steinberg
Epidermal Growth Factor-Induced Cyclooxygenase-2 Expression Is Mediated through Phosphatidylinositol-3 Kinase, Not Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase, in Recurrent Respiratory Papillomas
Clin. Cancer Res., September 1, 2005; 11(17): 6155 - 6161.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
X. Zhang, Z. Chen, M. S. Choe, Y. Lin, S.-Y. Sun, H. S. Wieand, H. J. C. Shin, A. Chen, F. R. Khuri, and D. M. Shin
Tumor Growth Inhibition by Simultaneously Blocking Epidermal Growth Factor Receptor and Cyclooxygenase-2 in a Xenograft Model
Clin. Cancer Res., September 1, 2005; 11(17): 6261 - 6269.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. K. Altorki, J. L. Port, F. Zhang, D. Golijanin, H. T. Thaler, A. J. Duffield-Lillico, K. Subbaramaiah, and A. J. Dannenberg
Chemotherapy Induces the Expression of Cyclooxygenase-2 in Non-Small Cell Lung Cancer
Clin. Cancer Res., June 1, 2005; 11(11): 4191 - 4197.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. Vallbohmer, W. Zhang, M. Gordon, D. Y. Yang, J. Yun, O. A. Press, K. E. Rhodes, A. E. Sherrod, S. Iqbal, K. D. Danenberg, et al.
Molecular Determinants of Cetuximab Efficacy
J. Clin. Oncol., May 20, 2005; 23(15): 3536 - 3544.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Symowicz, B. P. Adley, M. M.M. Woo, N. Auersperg, L. G. Hudson, and M. S. Stack
Cyclooxygenase-2 Functions as a Downstream Mediator of Lysophosphatidic Acid to Promote Aggressive Behavior in Ovarian Carcinoma Cells
Cancer Res., March 15, 2005; 65(6): 2234 - 2242.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. I. Patel, K. Subbaramaiah, B. Du, M. Chang, P. Yang, R. A. Newman, C. Cordon-Cardo, H. T. Thaler, and A. J. Dannenberg
Celecoxib Inhibits Prostate Cancer Growth: Evidence of a Cyclooxygenase-2-Independent Mechanism
Clin. Cancer Res., March 1, 2005; 11(5): 1999 - 2007.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. Tuccillo, M. Romano, T. Troiani, E. Martinelli, F. Morgillo, F. De Vita, R. Bianco, G. Fontanini, R. A. Bianco, G. Tortora, et al.
Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor-2 and Epidermal Growth Factor Receptor Small Molecule Tyrosine Kinase Inhibitor, in Combination with SC-236, a Cyclooxygenase-2 Inhibitor
Clin. Cancer Res., February 1, 2005; 11(3): 1268 - 1276.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Moraitis, B. Du, M. S. De Lorenzo, J. O. Boyle, B. B. Weksler, E. G. Cohen, J. F. Carew, N. K. Altorki, L. Kopelovich, K. Subbaramaiah, et al.
Levels of Cyclooxygenase-2 Are Increased in the Oral Mucosa of Smokers: Evidence for the Role of Epidermal Growth Factor Receptor and Its Ligands
Cancer Res., January 15, 2005; 65(2): 664 - 670.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. J. Dannenberg, S. M. Lippman, J. R. Mann, K. Subbaramaiah, and R. N. DuBois
Cyclooxygenase-2 and Epidermal Growth Factor Receptor: Pharmacologic Targets for Chemoprevention
J. Clin. Oncol., January 10, 2005; 23(2): 254 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. E. Zeytin, A. C. Patel, C. J. Rogers, D. Canter, S. D. Hursting, J. Schlom, and J. W. Greiner
Combination of a Poxvirus-Based Vaccine with a Cyclooxygenase-2 Inhibitor (Celecoxib) Elicits Antitumor Immunity and Long-Term Survival in CEA.Tg/MIN Mice
Cancer Res., May 15, 2004; 64(10): 3668 - 3678.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Wei, L. Wang, Y. He, H. Q. Xiong, J. L. Abbruzzese, and K. Xie
Celecoxib Inhibits Vascular Endothelial Growth Factor Expression in and Reduces Angiogenesis and Metastasis of Human Pancreatic Cancer via Suppression of Sp1 Transcription Factor Activity
Cancer Res., March 15, 2004; 64(6): 2030 - 2038.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. E. Kim, Y. B. Kim, N. H. Cho, H.-C. Chung, H. R. Pyo, J. D. Lee, T. K. Park, W. S. Koom, M. Chun, and C. O. Suh
Synchronous Coexpression of Epidermal Growth Factor Receptor and Cyclooxygenase-2 in Carcinomas of the Uterine Cervix: A Potential Predictor of Poor Survival
Clin. Cancer Res., February 15, 2004; 10(4): 1366 - 1374.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. J. Sales, S. A. Milne, A. R. W. Williams, R. A. Anderson, and H. N. Jabbour
Expression, Localization, and Signaling of Prostaglandin F2{alpha} Receptor in Human Endometrial Adenocarcinoma: Regulation of Proliferation by Activation of the Epidermal Growth Factor Receptor and Mitogen-Activated Protein Kinase Signaling Pathways
J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 986 - 993.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. Golijanin, J.-Y. Tan, A. Kazior, E. G. Cohen, P. Russo, G. Dalbagni, K. J. Auborn, K. Subbaramaiah, and A. J. Dannenberg
Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Are Overexpressed in Squamous Cell Carcinoma of the Penis
Clin. Cancer Res., February 1, 2004; 10(3): 1024 - 1031.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
P. E. Castle, T. M. Phillips, A. Hildesheim, R. Herrero, M. C. Bratti, A. C. Rodriguez, L. A. Morera, R. Pfeiffer, M. L. Hutchinson, L. A. Pinto, et al.
Immune Profiling of Plasma and Cervical Secretions Using Recycling Immunoaffinity Chromatography
Cancer Epidemiol. Biomarkers Prev., December 1, 2003; 12(12): 1449 - 1456.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. Lanza-Jacoby, S. Miller, J. Flynn, K. Gallatig, C. Daskalakis, J. L. Masferrer, B. S. Zweifel, H. Sembhi, and I. H. Russo
The Cyclooxygenase-2 Inhibitor, Celecoxib, Prevents the Development of Mammary Tumors in HER-2/neu Mice
Cancer Epidemiol. Biomarkers Prev., December 1, 2003; 12(12): 1486 - 1491.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. S. De Lorenzo, K. Yamaguchi, K. Subbaramaiah, and A. J. Dannenberg
Bryostatin-1 Stimulates the Transcription of Cyclooxygenase-2: Evidence for an Activator Protein-1-Dependent Mechanism
Clin. Cancer Res., October 15, 2003; 9(13): 5036 - 5043.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
H. Choy and L. Milas
Enhancing Radiotherapy With Cyclooxygenase-2 Enzyme Inhibitors: A Rational Advance?
J Natl Cancer Inst, October 1, 2003; 95(19): 1440 - 1452.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Han, H. Inoue, L. C. Flowers, and N. Sidell
Control of COX-2 Gene Expression through Peroxisome Proliferator-Activated Receptor {gamma} in Human Cervical Cancer Cells
Clin. Cancer Res., October 1, 2003; 9(12): 4627 - 4635.
[Abstract] [Full Text] [PDF]

Home page
 J Natl Cancer Inst MonogrHome page
P. E. Castle and A. R. Giuliano
Chapter 4: Genital Tract Infections, Cervical Inflammation, and Antioxidant Nutrients--Assessing Their Roles as Human Papillomavirus Cofactors
J Natl Cancer Inst Monographs, June 1, 2003; 2003(31): 29 - 34.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
G. P. Smyth, P. P. Stapleton, C. B. Barden, J. R. Mestre, T. A. Freeman, M. D. Duff, S. Maddali, Z. Yan, and J. M. Daly
Renal Cell Carcinoma Induces Prostaglandin E2 and T-Helper Type 2 Cytokine Production in Peripheral Blood Mononuclear Cells
Ann. Surg. Oncol., May 1, 2003; 10(4): 455 - 462.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. Tortora, R. Caputo, V. Damiano, D. Melisi, R. Bianco, G. Fontanini, B. M. Veneziani, S. De Placido, A. R. Bianco, and F. Ciardiello
Combination of a Selective Cyclooxygenase-2 Inhibitor with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 and Protein Kinase A Antisense Causes Cooperative Antitumor and Antiangiogenic Effect
Clin. Cancer Res., April 1, 2003; 9(4): 1566 - 1572.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
K. J. Sales, A. A. Katz, R. P. Millar, and H. N. Jabbour
Seminal plasma activates cyclooxygenase-2 and prostaglandin E2 receptor expression and signalling in cervical adenocarcinoma cells
Mol. Hum. Reprod., December 1, 2002; 8(12): 1065 - 1070.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. S. Zweifel, T. W. Davis, R. L. Ornberg, and J. L. Masferrer
Direct Evidence for a Role of Cyclooxygenase 2-derived Prostaglandin E2 in Human Head and Neck Xenograft Tumors
Cancer Res., November 15, 2002; 62(22): 6706 - 6711.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
W. E. Hardman
Omega-3 Fatty Acids to Augment Cancer Therapy
J. Nutr., November 1, 2002; 132(11): 3508S - 3512.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
G. Ferrandina, L. Lauriola, G. F. Zannoni, A. Fagotti, F. Fanfani, F. Legge, N. Maggiano, M. Gessi, S. Mancuso, F. O. Ranelletti, et al.
Increased cyclooxygenase-2 (COX-2) expression is associated with chemotherapy resistance and outcome in ovarian cancer patients
Ann. Onc., August 1, 2002; 13(8): 1205 - 1211.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. S. Carlton, R. Gopalakrishnan, A. Gupta, B. W. Liston, S. Habib, M. A. Morse, and G. D. Stoner
Piroxicam Is an Ineffective Inhibitor of N-Nitrosomethylbenzylamine-induced Tumorigenesis in the Rat Esophagus
Cancer Res., August 1, 2002; 62(15): 4376 - 4382.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. A. Wardlaw, N. Zhang, and S. A. Belinsky
Transcriptional Regulation of Basal Cyclooxygenase-2 Expression in Murine Lung Tumor-Derived Cell Lines by CCAAT/Enhancer-Binding Protein and Activating Transcription Factor/cAMP Response Element-Binding Protein
Mol. Pharmacol., August 1, 2002; 62(2): 326 - 333.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Subbaramaiah, L. Norton, W. Gerald, and A. J. Dannenberg
Cyclooxygenase-2 Is Overexpressed in HER-2/neu-positive Breast Cancer. EVIDENCE FOR INVOLVEMENT OF AP-1 AND PEA3
J. Biol. Chem., May 17, 2002; 277(21): 18649 - 18657.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
A. R. Munkarah, R. Morris, P. Baumann, G. Deppe, J. Malone, M. P. Diamond, and G. M. Saed
Effects of Prostaglandin E2 on Proliferation and Apoptosis of Epithelial Ovarian Cancer Cells
Reproductive Sciences, May 1, 2002; 9(3): 168 - 173.
[Abstract] [PDF]

Home page
 Cancer Res.Home page
K. Subbaramaiah, P. A. Cole, and A. J. Dannenberg
Retinoids and Carnosol Suppress Cyclooxygenase-2 Transcription by CREB-binding Protein/p300-dependent and -independent Mechanisms
Cancer Res., May 1, 2002; 62(9): 2522 - 2530.
[Abstract] [Full Text] [PDF]

Home page
 Integr Cancer TherHome page
J. M. Wallace
Nutritional and Botanical Modulation of the Inflammatory Cascade--Eicosanoids, Cyclooxygenases, and Lipoxygenases-- As an Adjunct in Cancer Therapy
Integr Cancer Ther, March 1, 2002; 1(1): 7 - 37.
[Abstract] [PDF]

Home page
 JCOHome page
G. Ferrandina, L. Lauriola, M. G. Distefano, G. F. Zannoni, M. Gessi, F. Legge, N. Maggiano, S. Mancuso, A. Capelli, G. Scambia, et al.
Increased Cyclooxygenase-2 Expression Is Associated With Chemotherapy Resistance and Poor Survival in Cervical Cancer Patients
J. Clin. Oncol., February 15, 2002; 20(4): 973 - 981.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. C. Specht, O. N. Tucker, M. Hocever, D. Gonzalez, L. Teng, and T. J. Fahey III
Cyclooxygenase-2 Expression in Thyroid Nodules
J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 358 - 363.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
V. de Ledinghen, H. Liu, F. Zhang, C. R. Lo, K. Subbaramaiah, A. J. Dannenberg, and M. J. Czaja
Induction of cyclooxygenase-2 by tumor promoters in transformed and cytochrome P450 2E1-expressing hepatocytes
Carcinogenesis, January 1, 2002; 23(1): 73 - 79.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. J. Sales, A. A. Katz, B. Howard, R. P. Soeters, R. P. Millar, and H. N. Jabbour
Cyclooxygenase-1 Is Up-Regulated in Cervical Carcinomas: Autocrine/Paracrine Regulation of Cyclooxygenase-2, Prostaglandin E Receptors, and Angiogenic Factors by Cyclooxygenase-1
Cancer Res., January 1, 2002; 62(2): 424 - 432.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. Fujita, J. R. Mestre, J. B. Zeldis, K. Subbaramaiah, and A. J. Dannenberg
Thalidomide and Its Analogues Inhibit Lipopolysaccharide-mediated Induction of Cyclooxygenase-2
Clin. Cancer Res., November 1, 2001; 7(11): 3349 - 3355.
[Abstract] [Full Text] [PDF]

Home page
 Annals of Clinical & Laboratory ScienceHome page
E. Fosslien
Molecular Pathology of Cyclooxygenase-2 in Cancer-induced Angiogenesis
Ann. Clin. Lab. Sci., October 1, 2001; 31(4): 325 - 348.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2001 by the American Association for Cancer Research.