| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Molecular Oncology, Markers, Clinical Correlates |
2 Chain of Laminin-5 at the Invasive Front Is Associated with Recurrence and Poor Prognosis in Human Esophageal Squamous Cell Carcinoma1
First Department of Internal Medicine, Sapporo Medical University, Sapporo 060-8543 [H. Y., F. I., S. I., K. I.] and Surgery, Keiyukai Sapporo Hospital, Sapporo 030-0027, Japan [M. H.]
Purpose: Preferential expression of the 
2
chain of laminin-5 in invading carcinoma cells has been implicated in
tumor invasion. The aim of this study was to clarify the
clinicopathological and prognostic significance of laminin
2 chain expression in esophageal squamous cell carcinoma
(SCC).
Experimental Design: We analyzed the association between
immunohistochemically detected laminin 2 chain
expression in esophageal SCC and clinicopathological characteristics,
and we investigated whether laminin 2 chain is a
predictor of recurrence and/or survival.
Results: The cytoplasm of carcinoma cells was stained for
laminin 2 at levels much stronger than those in normal
esophageal basement membrane. The immunoreactivities at the invasive
front were often more intense than those at the superficial layer.
Sections with immunostaining signals in >30% of carcinoma cells at
the invasive front, which were observed in 44 of 100 cases, were judged
to be positive for laminin 2 chain. Laminin
2 chain positivity was significantly correlated with
depth of invasion, lymph node metastasis, distant metastasis, advanced
pTNM stage, recurrence, and recurrence within the first postoperative
year. Patients with laminin 2 chain-positive carcinoma
had a significantly shorter disease-free and overall survival time than
did those with laminin 2 chain-negative carcinoma.
Laminin 2 chain retained its significant predictive
value for disease-free and overall survival in multivariate analysis
that included conventional clinicopathological factors.
Conclusions: Our results suggest that the laminin
2 chain plays a key role in the progression of
esophageal carcinoma and that its detection is useful for the
prediction of recurrence and poor prognosis.
This article has been cited by other articles:
|
|
 |
|
  C. Chen, E. Mendez, J. Houck, W. Fan, P. Lohavanichbutr, D. Doody, B. Yueh, N. D. Futran, M. Upton, D. G. Farwell, et al. Gene Expression Profiling Identifies Genes Predictive of Oral Squamous Cell Carcinoma Cancer Epidemiol. Biomarkers Prev., August 1, 2008; 17(8): 2152 - 2162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-Z. Shou, N. Hu, M. Takikita, M. J. Roth, L. L. Johnson, C. Giffen, Q.-H. Wang, C. Wang, Y. Wang, H. Su, et al. Overexpression of CDC25B and LAMC2 mRNA and Protein in Esophageal Squamous Cell Carcinomas and Premalignant Lesions in Subjects from a High-Risk Population in China Cancer Epidemiol. Biomarkers Prev., June 1, 2008; 17(6): 1424 - 1435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tran, P. Rousselle, P. Nokelainen, S. Tallapragada, N. T. Nguyen, E. F. Fincher, and M. P. Marinkovich Targeting a Tumor-Specific Laminin Domain Critical for Human Carcinogenesis Cancer Res., April 15, 2008; 68(8): 2885 - 2894. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Takkunen, R. Grenman, M. Hukkanen, M. Korhonen, A. Garcia de Herreros, and I. Virtanen Snail-dependent and -independent Epithelial-Mesenchymal Transition in Oral Squamous Carcinoma Cells J. Histochem. Cytochem., November 1, 2006; 54(11): 1263 - 1275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Vitolo, L. Ciocci, G. Deriu, S. Spinelli, S. Cortese, L. Masuelli, S. Morrone, M. J. Filice, G. F. Coloni, P. G. Natali, et al. Laminin {alpha}2 Chain-Positive Vessels and Epidermal Growth Factor in Lung Neuroendocrine Carcinoma: A Model of a Novel Cooperative Role of Laminin-2 and Epidermal Growth Factor in Vessel Neoplastic Invasion and Metastasis Am. J. Pathol., March 1, 2006; 168(3): 991 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. C. Dietze, M. L. Bowie, K. Mrozek, L. E. Caldwell, C. Neal, R. J. Marjoram, M. M. Troch, G. R. Bean, K. K. Yokoyama, C. A. Ibarra, et al. CREB-binding protein regulates apoptosis and growth of HMECs grown in reconstituted ECM via laminin-5 J. Cell Sci., November 1, 2005; 118(21): 5005 - 5022. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Nilsson, C. Rubio, C. Lenander, G. Auer, and B. Glimelius Tumour budding detected by laminin-5 {gamma}2-chain immunohistochemistry is of prognostic value in epidermoid anal cancer Ann. Onc., June 1, 2005; 16(6): 893 - 898. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. F. Klees, R. M. Salasznyk, K. Kingsley, W. A. Williams, A. Boskey, and G. E. Plopper Laminin-5 Induces Osteogenic Gene Expression in Human Mesenchymal Stem Cells through an ERK-dependent Pathway Mol. Biol. Cell, February 1, 2005; 16(2): 881 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Natarajan, M. Saeb, C. P. Crum, S. B. Woo, P. H. McKee, and J. G. Rheinwald Co-Expression of p16INK4A and Laminin 5 {gamma}2 by Microinvasive and Superficial Squamous Cell Carcinomas in Vivo and by Migrating Wound and Senescent Keratinocytes in Culture Am. J. Pathol., August 1, 2003; 163(2): 477 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Schenk, E. Hintermann, M. Bilban, N. Koshikawa, C. Hojilla, R. Khokha, and V. Quaranta Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution J. Cell Biol., April 14, 2003; 161(1): 197 - 209. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
