This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Srivastava, S. Articles by Henson, D. E. Search for Related Content PubMed PubMed Citation Articles by Srivastava, S. Articles by Henson, D. E.

Biomarkers for Early Detection of Colon Cancer

Division of Cancer Prevention, National Cancer Institute, Rockville, Maryland 20852

There is an increasing demand for biomarkers in colon cancer for risk assessment, early detection, prognosis, and surrogate end points. A number of biomarkers have been identified for early detection of colon cancer, although the risk factors have not been identified extensively. The major advances in understanding colorectal cancer include the identification and the involvement of APC, p53, and Ki-ras in the development and progression of the disease, the identification of the aberrant crypt foci as an early preinvasive lesion, and its relation to the development of cancer. Detecting malignant neoplasms in the early stages offers clinical advantages; therefore, the National Cancer Institute has established an Early Detection Research Network. The emphasis of the network is on translational research and collaboration among scientists.

This article has been cited by other articles:

				S. K. Chan, O. L. Griffith, I. T. Tai, and S. J.M. Jones Meta-analysis of Colorectal Cancer Gene Expression Profiling Studies Identifies Consistently Reported Candidate Biomarkers Cancer Epidemiol. Biomarkers Prev., March 1, 2008; 17(3): 543 - 552. [Abstract] [Full Text] [PDF]

				H. K. Roy and J. D. Khandekar Biomarkers for the Early Detection of Cancer: An Inflammatory Concept Arch Intern Med, September 24, 2007; 167(17): 1822 - 1824. [Full Text] [PDF]

				K. L. Campbell, A. McTiernan, S. S. Li, B. E. Sorensen, Y. Yasui, J. W. Lampe, I. B. King, C. M. Ulrich, R. E. Rudolph, M. L. Irwin, et al. Effect of a 12-Month Exercise Intervention on the Apoptotic Regulating Proteins Bax and Bcl-2 in Colon Crypts: A Randomized Controlled Trial Cancer Epidemiol. Biomarkers Prev., September 1, 2007; 16(9): 1767 - 1774. [Abstract] [Full Text] [PDF]

				Z. Zhao, Y. Xiao, P. Elson, H. Tan, S. J. Plummer, M. Berk, P. P. Aung, I. C. Lavery, J. P. Achkar, L. Li, et al. Plasma Lysophosphatidylcholine Levels: Potential Biomarkers for Colorectal Cancer J. Clin. Oncol., July 1, 2007; 25(19): 2696 - 2701. [Abstract] [Full Text] [PDF]

				P. Ellmark, J. Ingvarsson, A. Carlsson, B. S. Lundin, C. Wingren, and C. A. K. Borrebaeck Identification of Protein Expression Signatures Associated with Helicobacter pylori Infection and Gastric Adenocarcinoma Using Recombinant Antibody Microarrays Mol. Cell. Proteomics, September 1, 2006; 5(9): 1638 - 1646. [Abstract] [Full Text] [PDF]

				C. Bianco, L. Strizzi, M. Mancino, A. Rehman, S. Hamada, K. Watanabe, A. De Luca, B. Jones, G. Balogh, J. Russo, et al. Identification of Cripto-1 as a Novel Serologic Marker for Breast and Colon Cancer Clin. Cancer Res., September 1, 2006; 12(17): 5158 - 5164. [Abstract] [Full Text] [PDF]

				X. Bi, Q. Lin, T. W. Foo, S. Joshi, T. You, H.-M. Shen, C. N. Ong, P. Y. Cheah, K. W. Eu, and C.-L. Hew Proteomic Analysis of Colorectal Cancer Reveals Alterations in Metabolic Pathways: Mechanism of Tumorigenesis Mol. Cell. Proteomics, June 1, 2006; 5(6): 1119 - 1130. [Abstract] [Full Text] [PDF]

				J.-D. Luo, E.-C. Chan, C.-L. Shih, T.-L. Chen, Y. Liang, T.-L. Hwang, and C.-C. Chiou Detection of rare mutant K-ras DNA in a single-tube reaction using peptide nucleic acid as both PCR clamp and sensor probe Nucleic Acids Res., January 23, 2006; 34(2): e12 - e12. [Abstract] [Full Text] [PDF]

				O. Kovbasnjuk, R. Mourtazina, B. Baibakov, T. Wang, C. Elowsky, M. A. Choti, A. Kane, and M. Donowitz The glycosphingolipid globotriaosylceramide in the metastatic transformation of colon cancer PNAS, December 27, 2005; 102(52): 19087 - 19092. [Abstract] [Full Text] [PDF]

				C. M. Payne, H. Holubec, C. Bernstein, H. Bernstein, K. Dvorak, S. B. Green, M. Wilson, M. Dall'Agnol, B. Dvorakova, J. Warneke, et al. Crypt-Restricted Loss and Decreased Protein Expression of Cytochrome c Oxidase Subunit I as Potential Hypothesis-Driven Biomarkers of Colon Cancer Risk Cancer Epidemiol. Biomarkers Prev., September 1, 2005; 14(9): 2066 - 2075. [Abstract] [Full Text] [PDF]

				H. Fujino, G. A. Vielhauer, and J. W. Regan Prostaglandin E2 Selectively Antagonizes Prostaglandin F2{alpha}-stimulated T-cell Factor/{beta}-Catenin Signaling Pathway by the FPB Prostanoid Receptor J. Biol. Chem., October 15, 2004; 279(42): 43386 - 43391. [Abstract] [Full Text] [PDF]

				M. A. Pereira, L. Tao, W. Wang, Y. Li, A. Umar, V. E. Steele, and R. A. Lubet Modulation by celecoxib and difluoromethylornithine of the methylation of DNA and the estrogen receptor-{alpha} gene in rat colon tumors Carcinogenesis, October 1, 2004; 25(10): 1917 - 1923. [Abstract] [Full Text] [PDF]

				J. H. Carter, L. E. Douglass, J. A. Deddens, B. M. Colligan, T. R. Bhatt, J. O. Pemberton, S. Konicek, J. Hom, M. Marshall, and J. R. Graff Pak-1 Expression Increases with Progression of Colorectal Carcinomas to Metastasis Clin. Cancer Res., May 15, 2004; 10(10): 3448 - 3456. [Abstract] [Full Text] [PDF]

				S.-X. Qiao, M. Yuan, Y.-L. Liu, X.-S. Lin, X.-P. Zhang, and M. Tobi Detection of Gastric Cancer and Premalignant Lesions by Novel Marker Glycoprotein 87 Using Monoclonal Antibody Adnab-9 Cancer Epidemiol. Biomarkers Prev., October 1, 2003; 12(10): 1095 - 1099. [Abstract] [Full Text] [PDF]

				K. A. Boynton, I. C. Summerhayes, D. A. Ahlquist, and A. P. Shuber DNA Integrity as a Potential Marker for Stool-based Detection of Colorectal Cancer Clin. Chem., July 1, 2003; 49(7): 1058 - 1065. [Abstract] [Full Text] [PDF]

				M. Hashimoto, Y. He, and E. S. Yeung On-line integration of PCR and cycle sequencing in capillaries: from human genomic DNA directly to called bases Nucleic Acids Res., April 15, 2003; 31(8): e41 - e41. [Abstract] [Full Text] [PDF]