| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
Departments of Medical Biochemistry [A. N., K. M., M. Ot., M. On., M. K.], Anatomical Pathology [T. M., M. T.], and Urology [S. N.], Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan; Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan [K. K.]; and Department of Urology, Kochi Medical School, Kochi 783-8505, Japan [T. S.]
We used suppression subtractive hybridization to identify highly expressed genes in the cancerous region of human renal cell carcinoma (RCC) compared with noncancerous tissue. Nine genes were identified to show increased expression in the cancerous region compared with the noncancerous region. The nine genes included thymosin ß4, secreted protein acidic and rich in cysteine (SPARC), Cap43, ceruloplasmin, serum amyloid A, osteopontin, heat shock protein 90 (HSP90), LOT1, and casein kinase I. Of these 9 genes, in situ hybridization with 10 clinical samples consistently showed a strong expression of Cap43 mRNA in infiltrating macrophages in RCCs, but not in cancer cells proliferating in an alveolar pattern. However, Cap43 mRNA was also apparently detected in epithelial cells of the renal proximal tubuli in noncancerous tissue. The higher expression of the Cap43 gene in the cancerous region of RCCs appears to depend on macrophage infiltration. Moreover, treatment with phorbol ester resulted in enhanced expression of the Cap43 gene in human monocytic cells in vitro. The expression of the Cap43 gene in infiltrating macrophages is discussed in association with the differentiated or activated status of monocyte/macrophage.
This article has been cited by other articles:
|
|
 |
|
  Y. Maruyama, M. Ono, A. Kawahara, T. Yokoyama, Y. Basaki, M. Kage, S. Aoyagi, H. Kinoshita, and M. Kuwano Tumor Growth Suppression in Pancreatic Cancer by a Putative Metastasis Suppressor Gene Cap43/NDRG1/Drg-1 through Modulation of Angiogenesis. Cancer Res., June 15, 2006; 66(12): 6233 - 6242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Fotovati, T. Fujii, M. Yamaguchi, M. Kage, K. Shirouzu, S. Oie, Y. Basaki, M. Ono, H. Yamana, and M. Kuwano 17{beta}-Estradiol Induces Down-Regulation of Cap43/NDRG1/Drg-1, a Putative Differentiation-Related and Metastasis Suppressor Gene, in Human Breast Cancer Cells. Clin. Cancer Res., May 15, 2006; 12(10): 3010 - 3018. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Gutfeld, D. Prus, Z. Ackerman, S. Dishon, R. P. Linke, M. Levin, and S. Urieli-Shoval Expression of Serum Amyloid A, in Normal, Dysplastic, and Neoplastic Human Colonic Mucosa: Implication for a Role in Colonic Tumorigenesis J. Histochem. Cytochem., January 1, 2006; 54(1): 63 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Knapp, L. Olson, S. Tye, J. R. Bethard, C. A. Welsh, Z. Rumbolt, I. Takacs, and B. L. Maria Case of Desmoplastic Infantile Ganglioglioma Secreting Ceruloplasmin J Child Neurol, November 1, 2005; 20(11): 920 - 924. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Stein, E. K. Thomas, B. Herzog, M. D. Westfall, J. V. Rocheleau, R. S. Jackson II, M. Wang, and P. Liang NDRG1 Is Necessary for p53-dependent Apoptosis J. Biol. Chem., November 19, 2004; 279(47): 48930 - 48940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Lee, H.-W. Lo, R.-P. Shao, S.-C. Wang, W. Xia, D. M. Gershenson, and M.-C. Hung Selective Activation of Ceruloplasmin Promoter in Ovarian Tumors: Potential Use for Gene Therapy Cancer Res., March 1, 2004; 64(5): 1788 - 1793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wakisaka, A. Furuta, K. Masuda, W. Morikawa, M. Kuwano, and T. Iwaki Cellular Distribution of NDRG1 Protein in the Rat Kidney and Brain During Normal Postnatal Development J. Histochem. Cytochem., November 1, 2003; 51(11): 1515 - 1525. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Itokawa, H. Nokihara, Y. Nishioka, S. Sone, Y. Iwamoto, Y. Yamada, J. Cherrington, G. McMahon, M. Shibuya, M. Kuwano, et al. Antiangiogenic Effect by SU5416 Is Partly Attributable to Inhibition of Flt-1 Receptor Signaling Mol. Cancer Ther., March 1, 2002; 1(5): 295 - 302. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
