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Cancer Genomics

Promises and Complexities¹

Cancer Genomics and Proteomics Program, Department of Pathology, Division of Pathology and Laboratory Medicine [W. Z., P. M. L., S. R. H.] and Department of Biostatistics [K. R. C., D. A. B.], The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030

The impending final deciphering of the complete human genome, coupled with the advancement of high-throughput technologies, is positioned to bring about a fundamental transformation in cancer research. The era of molecular biology is transforming into the era of genomic biology, with an unprecedented promise of understanding multifactorial diseases and of identifying specific targets that can be used to develop patient-tailored therapies. Although the genomic approach is in an early phase of its development and its tools need to be honed, the application of genomic technologies to cancer research has already generated exciting results both in target identification and in disease classification. In this article, we review some of the developments pertinent to cancer research, discuss potentially problematic areas associated with them, and comment on future trends and issues.

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