| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
Evanston Northwestern Hospital Research Institute and Northwestern University, Evanston, Illinois 60201 [A. D. T., S. M. E., S. L.]; University of California at San Francisco, San Francisco, California 93143 [D. H. M.]; and Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115 [D. J. K.]
Purpose: erbB-2 and epidermal growth factor receptor (EGFR) may mediate motility via signaling that enables changes in the actin cytoskeleton. A physical basis for this motility may depend on the coexpression of gelsolin, a Mr 80,000 actin-binding protein.
Experimental Design: The expression of erbB-2, EGFR, and gelsolin was analyzed in 790 archival invasive breast cancers. These data were compared with histological, clinical, and outcome data (median follow-up, 16.3 years).
Results: Protein overexpression was observed in overlapping subsets of breast cancers (38% of cases were erbB-2+; 15% of cases were EGFR+; and 56% of cases were gelsolin+). Tumor gelsolin was associated with overexpression of erbB-2 and EGFR, as well as with an aggressive tumor phenotype. By univariate and multivariate analyses, tumor gelsolin alone was not a prognostic factor. Overexpression of all three factors significantly predicted poor clinical outcome by univariate and multivariate analyses. For example, in node-positive patients, coexpression of all three markers was associated with a 3-year disease-specific survival (as compared with erbB-2+, EGFR+, gelsolin- patients, who had a median survival of 6 years).
Conclusions: These data suggest that gelsolin coexpression may be an important additional prognostic factor in erbB-2+, EGFR+ breast cancer patients. We hypothesize that this is due to the role of gelsolin in mediating motility and invasion.
This article has been cited by other articles:
|
|
 |
|
  B. H Brandt Single/Oligo-Cell PCR: Needs, Perspectives, and Limitations Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 625 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Emlet, K. A. Brown, D. L. Kociban, A. A. Pollice, C. A. Smith, B. B. L. Ong, and S. E. Shackney Response to trastuzumab, erlotinib, and bevacizumab, alone and in combination, is correlated with the level of human epidermal growth factor receptor-2 expression in human breast cancer cell lines Mol. Cancer Ther., October 1, 2007; 6(10): 2664 - 2674. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. K. Mukhopadhyay, E. Weisberg, D. Gilchrist, R. Bueno, D. J. Sugarbaker, and M. T. Jaklitsch Effectiveness of Trichostatin A as a Potential Candidate for Anticancer Therapy in Non-Small-Cell Lung Cancer. Ann. Thorac. Surg., March 1, 2006; 81(3): 1034 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. DiGiovanna, D. F. Stern, S. M. Edgerton, and A. D. Thor In Reply: J. Clin. Oncol., November 1, 2005; 23(31): 8119 - 8120. [Full Text] [PDF]
|
|
|
|
|
|
M. P. DiGiovanna, D. F. Stern, S. M. Edgerton, S. G. Whalen, D. Moore II, and A. D. Thor Relationship of Epidermal Growth Factor Receptor Expression to ErbB-2 Signaling Activity and Prognosis in Breast Cancer Patients J. Clin. Oncol., February 20, 2005; 23(6): 1152 - 1160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. Qiu, G. V. R. Chandramouli, K. W. Hunter, N. W. Alkharouf, J. E. Green, and E. T. Liu Global Expression Profiling Identifies Signatures of Tumor Virulence in MMTV-PyMT-Transgenic Mice: Correlation to Human Disease Cancer Res., September 1, 2004; 64(17): 5973 - 5981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Fernandez-Madrid, N. Tang, H. Alansari, J. L. Granda, L. Tait, K. C. Amirikia, M. Moroianu, X. Wang, and R. L. Karvonen Autoantibodies to Annexin XI-A and Other Autoantigens in the Diagnosis of Breast Cancer Cancer Res., August 1, 2004; 64(15): 5089 - 5096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.L. Tedesco, A.D. Thor, D.H. Johnson, Y. Shyr, K.A. Blum, L.J. Goldstein, W.J. Gradishar, B.P. Nicholson, D.E. Merkel, D. Murrey, et al. Docetaxel Combined With Trastuzumab Is an Active Regimen in HER-2 3+ Overexpressing and Fluorescent In Situ Hybridization-Positive Metastatic Breast Cancer: A Multi-Institutional Phase II Trial J. Clin. Oncol., March 15, 2004; 22(6): 1071 - 1077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Maul, Y. Song, K. J. Amann, S. C. Gerbin, T. D. Pollard, and D. D. Chang EPLIN regulates actin dynamics by cross-linking and stabilizing filaments J. Cell Biol., February 3, 2003; 160(3): 399 - 407. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
