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Testing of New Agents in Childhood Cancer Preclinical Models

Meeting Summary

St. Jude Children’s Research Hospital, Memphis, Tennessee 38101 [P. J. H.]; Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 [P. C. A., J. M. M.]; Texas Children’s Cancer Center, Houston, Texas 77024 [S. B.]; Neurologic Oncology Branch, Bethesda, Maryland 20892 [H. A. F.]; Memorial Sloan-Kettering Cancer Center, New York, New York 10021 [R. G.]; Children’s Cancer Institute Australia for Medical Research, (affiliated with the University of New South Wales and Sydney Children’s Hospital), Randwick, New South Wales, Australia [M. H., R. B. L.]; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892 [L. H.]; Food and Drug Administration, Rockville, Maryland 20852 [S. H.]; Biological Testing Branch, National Cancer Institute, Frederick, Maryland 21702 [M. G. H.]; Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756 [M. A. I.]; Molecular Genetics Section, National Cancer Institute, Bethesda, Maryland 20892 [G. M.]; Technology Transfer Branch, National Cancer Institute, Bethesda, Maryland 20892 [W. P.]; Children’s Hospital of Los Angeles, Los Angeles, California 90027 [P. R.]; University of California San Francisco School Of Medicine, San Francisco, California 94143 [K. S.]; University of California San Diego Medical Center, San Diego, California 92103 [A. Y.]; The Scripps Research Institute, La Jolla, California 92037 [J. Y.]; and Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland 20892-7436 [M. A. S.]

ABSTRACT

A workshop on pediatric preclinical testing, sponsored by the National Cancer Institute and the Children’s Oncology Group Phase 1 Consortium, was held on June 26–27, 2001 in Bethesda, Maryland. Drs. Peter Adamson, Peter Houghton, and Malcolm Smith organized and hosted the meeting. There were 20 participants from 12 institutions. The primary objectives of the workshop included: (a) development of a working inventory of available preclinical models (including human tumor xenografts in immunodeficient mice, transgenic and syngeneic tumors, and selected in vitro models), with a basic understanding of the strengths and weaknesses of each as possible components of a preclinical testing program; (b) identification of the key scientific issues related to establishment of a program for preclinical testing of new agents for their applicability to childhood cancers; and (c) identification of the key infrastructure requirements for a program for preclinical testing of new agents for their applicability to childhood cancers. This report is a synthesis of the workshop’s presentations and discussions.

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