Clinical Cancer Research Prevention Award Frontiers in Basic Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Buettner, R.
Right arrow Articles by Jove, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Buettner, R.
Right arrow Articles by Jove, R.
Clinical Cancer Research Vol. 8, 945-954, April 2002
© 2002 American Association for Cancer Research

Minireview

Activated STAT Signaling in Human Tumors Provides Novel Molecular Targets for Therapeutic Intervention1

Ralf Buettner, Linda B. Mora and Richard Jove2

Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute [R. B., L. B. M., R. J.], and Departments of Oncology [R. B., L. B. M., R. J.], Pathology [L. B. M., R. J.], and Biochemistry and Molecular Biology [R. J.], University of South Florida, College of Medicine, Tampa, Florida 33612

The signal transducers and activators of transcription (STAT)factors function as downstream effectors of cytokine and growth factor receptor signaling. Compared with normal cells and tissues, constitutively activated STATs have been detected in a wide variety of human cancer cell lines and primary tumors. STATs are activated by tyrosine phosphorylation, which is normally a transient and tightly regulated process. In tumor cells, constitutive activation of STATs is linked to persistent activity of tyrosine kinases, including Src, epidermal growth factor receptor, Janus kinases, Bcr-Abl, and many others. Such oncogenic tyrosine kinases are often activated as a consequence of permanent ligand/receptor engagement in autocrine or paracrine cytokine and growth factor signaling or represent autonomous constitutively active enzymes as a result of genetic alterations found in tumor but not normal cells. Persistent signaling of specific STATs, in particular Stat3 and Stat5, has been demonstrated to directly contribute to oncogenesis by stimulating cell proliferation and preventing apoptosis. STATs participate in oncogenesis through up-regulation of genes encoding apoptosis inhibitors and cell cycle regulators such as Bcl-xL, Mcl-1, cyclins D1/D2, and c-Myc. Inhibition of constitutively active STAT signaling pathways has been shown repeatedly to inhibit tumor cell growth in vitro and in vivo and provides a novel means for therapeutic intervention in human cancer. In this review, we will: (a) explain the mechanisms of STAT activation in normal and malignant signaling; (b) summarize recent evidence for the critical role of constitutively activated Stat3 and Stat5 in oncogenesis; (c) identify candidate STAT target genes implicated in tumor progression; and (d) discuss molecular and pharmacological strategies to interfere with STAT signaling for potential therapeutic intervention in human cancer.




This article has been cited by other articles:


Home page
 Arch DermatolHome page
D. K. Woo, C. R. Jones, M. N. Vanoli-Storz, S. Kohler, S. Reddy, R. Advani, R. T. Hoppe, and Y. H. Kim
Prognostic Factors in Primary Cutaneous Anaplastic Large Cell Lymphoma: Characterization of Clinical Subset With Worse Outcome
Arch Dermatol, June 1, 2009; 145(6): 667 - 674.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J. Alvaro-Blanco, L. Martinez-Gac, E. Calonge, M. Rodriguez-Martinez, I. Molina-Privado, J. M. Redondo, J. Alcami, E. K. Flemington, and M. R. Campanero
A novel factor distinct from E2F mediates C-MYC promoter activation through its E2F element during exit from quiescence
Carcinogenesis, March 1, 2009; 30(3): 440 - 448.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. M. Gozgit, G. Bebernitz, P. Patil, M. Ye, J. Parmentier, J. Wu, N. Su, T. Wang, S. Ioannidis, A. Davies, et al.
Effects of the JAK2 Inhibitor, AZ960, on Pim/BAD/BCL-xL Survival Signaling in the Human JAK2 V617F Cell Line SET-2
J. Biol. Chem., November 21, 2008; 283(47): 32334 - 32343.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. A. Kerenyi, F. Grebien, H. Gehart, M. Schifrer, M. Artaker, B. Kovacic, H. Beug, R. Moriggl, and E. W. Mullner
Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1
Blood, November 1, 2008; 112(9): 3878 - 3888.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. Lamprecht, S. Kreher, I. Anagnostopoulos, K. Johrens, G. Monteleone, F. Jundt, H. Stein, M. Janz, B. Dorken, and S. Mathas
Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3{alpha}
Blood, October 15, 2008; 112(8): 3339 - 3347.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. N. Meyer, C. W. McAndrew, and D. J. Donoghue
Nordihydroguaiaretic Acid Inhibits an Activated Fibroblast Growth Factor Receptor 3 Mutant and Blocks Downstream Signaling in Multiple Myeloma Cells
Cancer Res., September 15, 2008; 68(18): 7362 - 7370.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S.-M. Sheen-Chen, C.-C. Huang, R.-P. Tang, F.-F. Chou, and H.-L. Eng
Prognostic Value of Signal Transducers and Activators of Transcription 3 in Breast Cancer
Cancer Epidemiol. Biomarkers Prev., September 1, 2008; 17(9): 2286 - 2290.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Fava, G. Alpini, C. Rychlicki, S. Saccomanno, S. DeMorrow, L. Trozzi, C. Candelaresi, J. Venter, A. Di Sario, M. Marzioni, et al.
Leptin Enhances Cholangiocarcinoma Cell Growth
Cancer Res., August 15, 2008; 68(16): 6752 - 6761.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. S. Ahn, G. Sethi, B. Sung, A. Goel, R. Ralhan, and B. B. Aggarwal
Guggulsterone, a Farnesoid X Receptor Antagonist, Inhibits Constitutive and Inducible STAT3 Activation through Induction of a Protein Tyrosine Phosphatase SHP-1
Cancer Res., June 1, 2008; 68(11): 4406 - 4415.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
H. D. Lewis, A. Winter, T. F. Murphy, S. Tripathi, V. N. Pandey, and B. E. Barton
STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5' and 3' ends
Mol. Cancer Ther., June 1, 2008; 7(6): 1543 - 1550.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Z. Cheng, W. Zhang, M. Sun, Q. Wang, D. Coppola, M. Mansour, L. Xu, C. Costanzo, J. Q. Cheng, and L.-H. Wang
Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function
J. Biol. Chem., May 23, 2008; 283(21): 14665 - 14673.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
V. R. Fantin, A. Loboda, C. P. Paweletz, R. C. Hendrickson, J. W. Pierce, J. A. Roth, L. Li, F. Gooden, S. Korenchuk, X. S. Hou, et al.
Constitutive Activation of Signal Transducers and Activators of Transcription Predicts Vorinostat Resistance in Cutaneous T-Cell Lymphoma
Cancer Res., May 15, 2008; 68(10): 3785 - 3794.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. Chatterjee, E. Sabo, R. Tavares, and M. B. Resnick
Inverse Association between Raf Kinase Inhibitory Protein and Signal Transducers and Activators of Transcription 3 Expression in Gastric Adenocarcinoma Patients: Implications for Clinical Outcome
Clin. Cancer Res., May 15, 2008; 14(10): 2994 - 3001.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
E. C. Brantley and E. N. Benveniste
Signal Transducer and Activator of Transcription-3: A Molecular Hub for Signaling Pathways in Gliomas
Mol. Cancer Res., May 1, 2008; 6(5): 675 - 684.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. M. Mohankumar, J. K. Perry, N. Kannan, K. Kohno, P. D. Gluckman, B. S. Emerald, and P. E. Lobie
Transcriptional Activation of Signal Transducer and Activator of Transcription (STAT) 3 and STAT5B Partially Mediate Homeobox A1-Stimulated Oncogenic Transformation of the Immortalized Human Mammary Epithelial Cell
Endocrinology, May 1, 2008; 149(5): 2219 - 2229.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
T. Mijatovic, N. De Neve, P. Gailly, V. Mathieu, B. Haibe-Kains, G. Bontempi, J. Lapeira, C. Decaestecker, V. Facchini, and R. Kiss
Nucleolus and c-Myc: potential targets of cardenolide-mediated antitumor activity
Mol. Cancer Ther., May 1, 2008; 7(5): 1285 - 1296.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
J. S. Fitzgerald, T. G. Poehlmann, E. Schleussner, and U. R. Markert
Trophoblast invasion: the role of intracellular cytokine signalling via signal transducer and activator of transcription 3 (STAT3)
Hum. Reprod. Update, April 17, 2008; (2008) dmn010v1.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
H Kothmaier, F Quehenberger, I Halbwedl, P Morbini, F Demirag, H Zeren, C E Comin, B Murer, P T Cagle, R Attanoos, et al.
EGFR and PDGFR differentially promote growth in malignant epithelioid mesothelioma of short and long term survivors
Thorax, April 1, 2008; 63(4): 345 - 351.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W.-K. Chu, P.-M. Dai, H.-L. Li, and J.-K. Chen
Transcriptional Activity of the {Delta}Np63 Promoter Is Regulated by STAT3
J. Biol. Chem., March 21, 2008; 283(12): 7328 - 7337.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Fujita, X. Zhu, K. Sasaki, R. Ueda, K. L. Low, I. F. Pollack, and H. Okada
Inhibition of STAT3 Promotes the Efficacy of Adoptive Transfer Therapy Using Type-1 CTLs by Modulation of the Immunological Microenvironment in a Murine Intracranial Glioma
J. Immunol., February 15, 2008; 180(4): 2089 - 2098.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. Zhang, L. Gao, Y. Li, G. Lin, Y. Shao, K. Ji, H. Yu, J. Hu, D. V. Kalvakolanu, D. J. Kopecko, et al.
Effects of Plasmid-Based Stat3-Specific Short Hairpin RNA and GRIM-19 on PC-3M Tumor Cell Growth
Clin. Cancer Res., January 15, 2008; 14(2): 559 - 568.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
H. Neuwirt, M. Puhr, I. T Cavarretta, M. Mitterberger, A. Hobisch, and Z. Culig
Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion
Endocr. Relat. Cancer, December 1, 2007; 14(4): 1007 - 1019.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
S. Kreis, G. A. Munz, S. Haan, P. C. Heinrich, and I. Behrmann
Cell Density Dependent Increase of Constitutive Signal Transducers and Activators of Transcription 3 Activity in Melanoma Cells Is Mediated by Janus Kinases
Mol. Cancer Res., December 1, 2007; 5(12): 1331 - 1341.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. S. Redell, A. Tsimelzon, S. G. Hilsenbeck, and D. J. Tweardy
Conditional overexpression of Stat3{alpha} in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern
J. Leukoc. Biol., October 1, 2007; 82(4): 975 - 985.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. Kalakonda, S. C. Nallar, P. Gong, D. J. Lindner, S. E. Goldblum, S. P. Reddy, and D. V. Kalvakolanu
Tumor Suppressive Protein Gene Associated with Retinoid-Interferon-Induced Mortality (GRIM)-19 Inhibits src-Induced Oncogenic Transformation at Multiple Levels
Am. J. Pathol., October 1, 2007; 171(4): 1352 - 1368.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Dvorak, M. Chavarria, C. M. Payne, L. Ramsey, C. Crowley-Weber, B. Dvorakova, B. Dvorak, H. Bernstein, H. Holubec, R. E. Sampliner, et al.
Activation of the Interleukin-6/STAT3 Antiapoptotic Pathway in Esophageal Cells by Bile Acids and Low pH: Relevance to Barrett's Esophagus
Clin. Cancer Res., September 15, 2007; 13(18): 5305 - 5313.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
A. K. Pathak, M. Bhutani, A. S. Nair, K. S. Ahn, A. Chakraborty, H. Kadara, S. Guha, G. Sethi, and B. B. Aggarwal
Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells
Mol. Cancer Res., September 1, 2007; 5(9): 943 - 955.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
R. Buettner, M. Huang, T. Gritsko, J. Karras, S. Enkemann, T. Mesa, S. Nam, H. Yu, and R. Jove
Activated Signal Transducers and Activators of Transcription 3 Signaling Induces CD46 Expression and Protects Human Cancer Cells from Complement-Dependent Cytotoxicity
Mol. Cancer Res., August 1, 2007; 5(8): 823 - 832.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Kalakonda, S. C. Nallar, D. J. Lindner, J. Hu, S. P. Reddy, and D. V. Kalvakolanu
Tumor-Suppressive Activity of the Cell Death Activator GRIM-19 on a Constitutively Active Signal Transducer and Activator of Transcription 3
Cancer Res., July 1, 2007; 67(13): 6212 - 6220.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
X. Liu, A. M. Das, J. Seideman, D. Griswold, C. N. Afuh, T. Kobayashi, S. Abe, Q. Fang, M. Hashimoto, H. Kim, et al.
The CC Chemokine Ligand 2 (CCL2) Mediates Fibroblast Survival through IL-6
Am. J. Respir. Cell Mol. Biol., July 1, 2007; 37(1): 121 - 128.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Siddiquee, S. Zhang, W. C. Guida, M. A. Blaskovich, B. Greedy, H. R. Lawrence, M. L. R. Yip, R. Jove, M. M. McLaughlin, N. J. Lawrence, et al.
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
PNAS, May 1, 2007; 104(18): 7391 - 7396.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. Y. Feng, C. A. Lopez, D. P. Normolle, S. Varambally, X. Li, P. Y. Chun, M. A. Davis, T. S. Lawrence, and M. K. Nyati
Effect of Epidermal Growth Factor Receptor Inhibitor Class in the Treatment of Head and Neck Cancer with Concurrent Radiochemotherapy In vivo
Clin. Cancer Res., April 15, 2007; 13(8): 2512 - 2518.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
S. Nam, A. Williams, A. Vultur, A. List, K. Bhalla, D. Smith, F. Y. Lee, and R. Jove
Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells
Mol. Cancer Ther., April 1, 2007; 6(4): 1400 - 1405.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W.-C. Li, S.-L. Ye, R.-X. Sun, Y.-K. Liu, Z.-Y. Tang, Y. Kim, J. G. Karras, and H. Zhang
Inhibition of Growth and Metastasis of Human Hepatocellular Carcinoma by Antisense Oligonucleotide Targeting Signal Transducer and Activator of Transcription 3
Clin. Cancer Res., December 1, 2006; 12(23): 7140 - 7148.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. S. Nagy, H. Rui, S. M. Stepkowski, J. Karras, and R. A. Kirken
A Preferential Role for STAT5, not Constitutively Active STAT3, in Promoting Survival of a Human Lymphoid Tumor
J. Immunol., October 15, 2006; 177(8): 5032 - 5040.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. M. Weaver and C. M. Silva
Modulation of Signal Transducer and Activator of Transcription 5b Activity in Breast Cancer Cells by Mutation of Tyrosines within the Transactivation Domain
Mol. Endocrinol., October 1, 2006; 20(10): 2392 - 2405.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Q. Zhang, H. Y. Wang, A. Woetmann, P. N. Raghunath, N. Odum, and M. A. Wasik
STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes
Blood, August 1, 2006; 108(3): 1058 - 1064.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Liby, N. Voong, C. R. Williams, R. Risingsong, D. B. Royce, T. Honda, G. W. Gribble, M. B. Sporn, and J. J. Letterio
The Synthetic Triterpenoid CDDO-Imidazolide Suppresses STAT Phosphorylation and Induces Apoptosis in Myeloma and Lung Cancer Cells.
Clin. Cancer Res., July 15, 2006; 12(14): 4288 - 4293.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. E. Levy and G. Inghirami
STAT3: A multifaceted oncogene
PNAS, July 5, 2006; 103(27): 10151 - 10152.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Kasprzycka, M. Marzec, X. Liu, Q. Zhang, and M. A. Wasik
From the Cover: Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3
PNAS, June 27, 2006; 103(26): 9964 - 9969.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. T. Merrick, J. Kittelson, R. Winterhalder, G. Kotantoulas, S. Ingeberg, R. L. Keith, T. C. Kennedy, Y. E. Miller, W. A. Franklin, and F. R. Hirsch
Analysis of c-ErbB1/epidermal growth factor receptor and c-ErbB2/HER-2 expression in bronchial dysplasia: evaluation of potential targets for chemoprevention of lung cancer.
Clin. Cancer Res., April 1, 2006; 12(7 Pt 1): 2281 - 2288.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
A. Kotha, M. Sekharam, L. Cilenti, K. Siddiquee, A. Khaled, A. S. Zervos, B. Carter, J. Turkson, and R. Jove
Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein.
Mol. Cancer Ther., March 1, 2006; 5(3): 621 - 629.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
W. Zhang, C. S. Zong, U. Hermanto, P. Lopez-Bergami, Z. Ronai, and L.-H. Wang
RACK1 Recruits STAT3 Specifically to Insulin and Insulin-Like Growth Factor 1 Receptors for Activation, Which Is Important for Regulating Anchorage-Independent Growth
Mol. Cell. Biol., January 15, 2006; 26(2): 413 - 424.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
J. H. Lee, D. Schutte, G. Wulf, L. Fuzesi, H.-J. Radzun, S. Schweyer, W. Engel, and K. Nayernia
Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway
Hum. Mol. Genet., January 15, 2006; 15(2): 201 - 211.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Gritsko, A. Williams, J. Turkson, S. Kaneko, T. Bowman, M. Huang, S. Nam, I. Eweis, N. Diaz, D. Sullivan, et al.
Persistent Activation of Stat3 Signaling Induces Survivin Gene Expression and Confers Resistance to Apoptosis in Human Breast Cancer Cells
Clin. Cancer Res., January 1, 2006; 12(1): 11 - 19.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. Diaz, S. Minton, C. Cox, T. Bowman, T. Gritsko, R. Garcia, I. Eweis, M. Wloch, S. Livingston, E. Seijo, et al.
Activation of Stat3 in Primary Tumors from High-Risk Breast Cancer Patients Is Associated with Elevated Levels of Activated Src and Survivin Expression
Clin. Cancer Res., January 1, 2006; 12(1): 20 - 28.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
Y. K. Lee, C. R. Isham, S. H. Kaufman, and K. C. Bible
Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy
Mol. Cancer Ther., January 1, 2006; 5(1): 138 - 148.
[Abstract] [Full Text] [PDF]

Home page
 Integr Cancer TherHome page
M. F. McCarty and K. I. Block
Multifocal Angiostatic Therapy: An Update
Integr Cancer Ther, December 1, 2005; 4(4): 301 - 314.
[Abstract] [PDF]

Home page
 IOVSHome page
H. Mechoulam and E. A. Pierce
Expression and Activation of STAT3 in Ischemia-Induced Retinopathy
Invest. Ophthalmol. Vis. Sci., December 1, 2005; 46(12): 4409 - 4416.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. B. Haura, Z. Zheng, L. Song, A. Cantor, and G. Bepler
Activated Epidermal Growth Factor Receptor-Stat-3 Signaling Promotes Tumor Survival In vivo in Non-Small Cell Lung Cancer
Clin. Cancer Res., December 1, 2005; 11(23): 8288 - 8294.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Q. Lin, R. Lai, L. R. Chirieac, C. Li, V. A. Thomazy, I. Grammatikakis, G. Z. Rassidakis, W. Zhang, Y. Fujio, K. Kunisada, et al.
Constitutive Activation of JAK3/STAT3 in Colon Carcinoma Tumors and Cell Lines: Inhibition of JAK3/STAT3 Signaling Induces Apoptosis and Cell Cycle Arrest of Colon Carcinoma Cells
Am. J. Pathol., October 1, 2005; 167(4): 969 - 980.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Turkson, S. Zhang, L. B. Mora, A. Burns, S. Sebti, and R. Jove
A Novel Platinum Compound Inhibits Constitutive Stat3 Signaling and Induces Cell Cycle Arrest and Apoptosis of Malignant Cells
J. Biol. Chem., September 23, 2005; 280(38): 32979 - 32988.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. Gao, L. Zhang, J. Hu, F. Li, Y. Shao, D. Zhao, D. V. Kalvakolanu, D. J. Kopecko, X. Zhao, and D.-Q. Xu
Down-Regulation of Signal Transducer and Activator of Transcription 3 Expression Using Vector-Based Small Interfering RNAs Suppresses Growth of Human Prostate Tumor In vivo
Clin. Cancer Res., September 1, 2005; 11(17): 6333 - 6341.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. M. Ulane, A. Kentsis, C. D. Cruz, J.-P. Parisien, K. L. Schneider, and C. M. Horvath
Composition and Assembly of STAT-Targeting Ubiquitin Ligase Complexes: Paramyxovirus V Protein Carboxyl Terminus Is an Oligomerization Domain
J. Virol., August 15, 2005; 79(16): 10180 - 10189.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Nishimoto, Y. Yu, Z. Lu, X. Mao, Z. Ren, S. S. Watowich, G. B. Mills, W. S-L. Liao, X. Chen, R. C. Bast Jr., et al.
A Ras Homologue Member I Directly Inhibits Signal Transducers and Activators of Transcription 3 Translocation and Activity in Human Breast and Ovarian Cancer Cells
Cancer Res., August 1, 2005; 65(15): 6701 - 6710.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Yu, M. Dews, A. Park, J. W. Tobias, and A. Thomas-Tikhonenko
Inactivation of Myc in Murine Two-Hit B lymphomas Causes Dormancy with Elevated Levels of Interleukin 10 Receptor and CD20: Implications for Adjuvant Therapies
Cancer Res., June 15, 2005; 65(12): 5454 - 5461.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
R Rust, G Harms, T Blokzijl, M Boot, A Diepstra, J Kluiver, L Visser, S-C Peh, M Lim, W A Kamps, et al.
High expression of Mcl-1 in ALK positive and negative anaplastic large cell lymphoma
J. Clin. Pathol., May 1, 2005; 58(5): 520 - 524.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Nam, R. Buettner, J. Turkson, D. Kim, J. Q. Cheng, S. Muehlbeyer, F. Hippe, S. Vatter, K.-H. Merz, G. Eisenbrand, et al.
Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells
PNAS, April 26, 2005; 102(17): 5998 - 6003.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Kusmartsev and D. I. Gabrilovich
STAT1 Signaling Regulates Tumor-Associated Macrophage-Mediated T Cell Deletion
J. Immunol., April 15, 2005; 174(8): 4880 - 4891.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. J. Gu, L. Santiago, and B. S. Mitchell
Synergy between imatinib and mycophenolic acid in inducing apoptosis in cell lines expressing Bcr-Abl
Blood, April 15, 2005; 105(8): 3270 - 3277.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. J. Aichberger, M. Mayerhofer, M.-T. Krauth, H. Skvara, S. Florian, K. Sonneck, C. Akgul, S. Derdak, W. F. Pickl, V. Wacheck, et al.
Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides
Blood, April 15, 2005; 105(8): 3303 - 3311.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. Moucadel and S. N. Constantinescu
Differential STAT5 Signaling by Ligand-dependent and Constitutively Active Cytokine Receptors
J. Biol. Chem., April 8, 2005; 280(14): 13364 - 13373.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Burdelya, M. Kujawski, G. Niu, B. Zhong, T. Wang, S. Zhang, M. Kortylewski, K. Shain, H. Kay, J. Djeu, et al.
Stat3 Activity in Melanoma Cells Affects Migration of Immune Effector Cells and Nitric Oxide-Mediated Antitumor Effects
J. Immunol., April 1, 2005; 174(7): 3925 - 3931.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. Ravi, A. J. Jain, R. D. Schulick, V. Pham, T. S. Prouser, H. Allen, E. G. Mayer, H. Yu, D. M. Pardoll, A. Ashkenazi, et al.
Elimination of Hepatic Metastases of Colon Cancer Cells via p53-Independent Cross-Talk between Irinotecan and Apo2 Ligand/TRAIL
Cancer Res., December 15, 2004; 64(24): 9105 - 9114.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
J. Turkson, S. Zhang, J. Palmer, H. Kay, J. Stanko, L. B. Mora, S. Sebti, H. Yu, and R. Jove
Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity
Mol. Cancer Ther., December 1, 2004; 3(12): 1533 - 1542.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. V. Yezhelyev, G. Koehl, M. Guba, T. Brabletz, K.-W. Jauch, A. Ryan, A. Barge, T. Green, M. Fennell, and C. J. Bruns
Inhibition of Src Tyrosine Kinase as Treatment for Human Pancreatic Cancer Growing Orthotopically in Nude Mice
Clin. Cancer Res., December 1, 2004; 10(23): 8028 - 8036.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
W. G. Douglas, E. Tracy, D. Tan, J. Yu, W. L. Hicks Jr., N. R. Rigual, T. R. Loree, Y. Wang, and H. Baumann
Development of Head and Neck Squamous Cell Carcinoma Is Associated With Altered Cytokine Responsiveness
Mol. Cancer Res., October 1, 2004; 2(10): 585 - 593.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
B. E. Barton, T. F. Murphy, P. Shu, H. F. Huang, M. Meyenhofen, and A. Barton
Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines
Mol. Cancer Ther., October 1, 2004; 3(10): 1183 - 1191.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Jing, Y. Li, W. Xiong, W. Sha, L. Jing, and D. J. Tweardy
G-Quartet Oligonucleotides: A New Class of Signal Transducer and Activator of Transcription 3 Inhibitors That Suppresses Growth of Prostate and Breast Tumors through Induction of Apoptosis
Cancer Res., September 15, 2004; 64(18): 6603 - 6609.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
H. Siavash, N.G. Nikitakis, and J.J. Sauk
SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION: INSIGHTS INTO THE MOLECULAR BASIS OF ORAL CANCER
Critical Reviews in Oral Biology & Medicine, September 1, 2004; 15(5): 298 - 307.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
D. E. Spaner
Amplifying cancer vaccine responses by modifying pathogenic gene programs in tumor cells
J. Leukoc. Biol., August 1, 2004; 76(2): 338 - 351.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y. Dai, M. Rahmani, X.-Y. Pei, P. Dent, and S. Grant
Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms
Blood, July 15, 2004; 104(2): 509 - 518.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. N. Meyer, R. F. Gastwirt, D. D. Schlaepfer, and D. J. Donoghue
The Cytoplasmic Tyrosine Kinase Pyk2 as a Novel Effector of Fibroblast Growth Factor Receptor 3 Activation
J. Biol. Chem., July 2, 2004; 279(27): 28450 - 28457.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. V. Scagliotti, G. Selvaggi, S. Novello, and F. R. Hirsch
The Biology of Epidermal Growth Factor Receptor in Lung Cancer
Clin. Cancer Res., June 15, 2004; 10(12): 4227S - 4232S.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. L. Silver, H. Naora, J. Liu, W. Cheng, and D. J. Montell
Activated Signal Transducer and Activator of Transcription (STAT) 3: Localization in Focal Adhesions and Function in Ovarian Cancer Cell Motility
Cancer Res., May 15, 2004; 64(10): 3550 - 3558.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. J. Peltola, K. Paukku, T. L. T. Aho, M. Ruuska, O. Silvennoinen, and P. J. Koskinen
Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3
Blood, May 15, 2004; 103(10): 3744 - 3750.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
A. Dowlati, D. Nethery, and J. A. Kern
Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy
Mol. Cancer Ther., April 1, 2004; 3(4): 459 - 463.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Dvorakova, C. M. Payne, L. Ramsey, H. Holubec, R. Sampliner, J. Dominguez, B. Dvorak, H. Bernstein, C. Bernstein, A. Prasad, et al.
Increased Expression and Secretion of Interleukin-6 in Patients with Barrett's Esophagus
Clin. Cancer Res., March 15, 2004; 10(6): 2020 - 2028.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Sredni, M. Weil, G. Khomenok, I. Lebenthal, S. Teitz, Y. Mardor, Z. Ram, A. Orenstein, A. Kershenovich, S. Michowiz, et al.
Ammonium Trichloro(dioxoethylene-o,o')tellurate (AS101) Sensitizes Tumors to Chemotherapy by Inhibiting the Tumor Interleukin 10 Autocrine Loop
Cancer Res., March 1, 2004; 64(5): 1843 - 1852.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
K. Nagel-Wolfrum, C. Buerger, I. Wittig, K. Butz, F. Hoppe-Seyler, and B. Groner
The Interaction of Specific Peptide Aptamers With the DNA Binding Domain and the Dimerization Domain of the Transcription Factor Stat3 Inhibits Transactivation and Induces Apoptosis in Tumor Cells
Mol. Cancer Res., March 1, 2004; 2(3): 170 - 182.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
J. Turkson, J. S. Kim, S. Zhang, J. Yuan, M. Huang, M. Glenn, E. Haura, S. Sebti, A. D. Hamilton, and R. Jove
Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity
Mol. Cancer Ther., March 1, 2004; 3(3): 261 - 269.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. N. Khodarev, M. Beckett, E. Labay, T. Darga, B. Roizman, and R. R. Weichselbaum
STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells
PNAS, February 10, 2004; 101(6): 1714 - 1719.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
H. Nakajima, M. Takenaka, J.-Y. Kaimori, T. Hamano, H. Iwatani, T. Sugaya, T. Ito, M. Hori, and E. Imai
Activation of the Signal Transducer and Activator of Transcription Signaling Pathway in Renal Proximal Tubular Cells by Albumin
J. Am. Soc. Nephrol., February 1, 2004; 15(2): 276 - 285.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
B. E. Barton, J. G. Karras, T. F. Murphy, A. Barton, and H. F-S. Huang
Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines
Mol. Cancer Ther., January 1, 2004; 3(1): 11 - 20.
[Abstract] [Full Text]

Home page
 Molecular Cancer TherapeuticsHome page
M. Nunes, C. Shi, and L. M. Greenberger
Phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase B, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, EKB-569, in tumor cells and normal human keratinocytes
Mol. Cancer Ther., January 1, 2004; 3(1): 21 - 27.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
Y. Nefedova, M. Huang, S. Kusmartsev, R. Bhattacharya, P. Cheng, R. Salup, R. Jove, and D. Gabrilovich
Hyperactivation of STAT3 Is Involved in Abnormal Differentiation of Dendritic Cells in Cancer
J. Immunol., January 1, 2004; 172(1): 464 - 474.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. V. Kazansky, D. M. Spencer, and N. M. Greenberg
Activation of Signal Transducer and Activator of Transcription 5 is Required for Progression of Autochthonous Prostate Cancer: Evidence from the Transgenic Adenocarcinoma of the Mouse Prostate System
Cancer Res., December 15, 2003; 63(24): 8757 - 8762.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. He, L. You, K. Uematsu, K. Zang, Z. Xu, A. Y. Lee, J. F. Costello, F. McCormick, and D. M. Jablons
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
PNAS, November 25, 2003; 100(24): 14133 - 14138.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Behbod, Z. S. Nagy, S. M. Stepkowski, J. Karras, C. R. Johnson, W. D. Jarvis, and R. A. Kirken
Specific Inhibition of Stat5a/b Promotes Apoptosis of IL-2-Responsive Primary and Tumor-Derived Lymphoid Cells
J. Immunol., October 15, 2003; 171(8): 3919 - 3927.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. Fahrig, J.-C. Heinrich, B. Nickel, F. Wilfert, C. Leisser, G. Krupitza, C. Praha, D. Sonntag, B. Fiedler, H. Scherthan, et al.
Inhibition of Induced Chemoresistance by Cotreatment with (E)-5-(2-Bromovinyl)-2'-Deoxyuridine (RP101)
Cancer Res., September 15, 2003; 63(18): 5745 - 5753.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Zhang, J. Yang, S. K. Roy, S. Tininini, J. Hu, J. F. Bromberg, V. Poli, G. R. Stark, and D. V. Kalvakolanu
The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3
PNAS, August 5, 2003; 100(16): 9342 - 9347.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. Rascle, J. A. Johnston, and B. Amati
Deacetylase Activity Is Required for Recruitment of the Basal Transcription Machinery and Transactivation by STAT5
Mol. Cell. Biol., June 15, 2003; 23(12): 4162 - 4173.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. M. Ulane, J. J. Rodriguez, J.-P. Parisien, and C. M. Horvath
STAT3 Ubiquitylation and Degradation by Mumps Virus Suppress Cytokine and Oncogene Signaling
J. Virol., June 1, 2003; 77(11): 6385 - 6393.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
Y. Yasuda, Y. Fujita, T. Matsuo, S. Koinuma, S. Hara, A. Tazaki, M. Onozaki, M. Hashimoto, T. Musha, K. Ogawa, et al.
Erythropoietin regulates tumour growth of human malignancies
Carcinogenesis, June 1, 2003; 24(6): 1021 - 1029.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
H. Chen, L. Hutt-Fletcher, L. Cao, and S. D. Hayward
A Positive Autoregulatory Loop of LMP1 Expression and STAT Activation in Epithelial Cells Latently Infected with Epstein-Barr Virus
J. Virol., April 1, 2003; 77(7): 4139 - 4148.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Kari, T. O. Chan, M. Rocha de Quadros, and U. Rodeck
Targeting the Epidermal Growth Factor Receptor in Cancer: Apoptosis Takes Center Stage
Cancer Res., January 1, 2003; 63(1): 1 - 5.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
D. R. Scoles, V. D. Nguyen, Y. Qin, C.-X. Sun, H. Morrison, D. H. Gutmann, and S.-M. Pulst
Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling
Hum. Mol. Genet., December 1, 2002; 11(25): 3179 - 3189.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
A. Martinez, M. Vos, L. Guedez, G. Kaur, Z. Chen, M. Garayoa, R. Pio, T. Moody, W. G. Stetler-Stevenson, H. K. Kleinman, et al.
The Effects of Adrenomedullin Overexpression in Breast Tumor Cells
J Natl Cancer Inst, August 21, 2002; 94(16): 1226 - 1237.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.