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Transcription Factors and Neoplasia

Vistas in Novel Drug Design

Department of Biochemistry, School of Medicine, University of Patras, GR-26110 Patras [M. V. K., A. G. P.], and Department of Histology and Embryology, School of Medicine, University of Athens, GR-11527 Athens [V. G. G.], Greece

Purpose: The fundamental role of gene transcription and the recognition of transcription factors as important control elements of cell growth, differentiation, and programmed cell death (apoptosis) aroused an ever-increasing interest for these proteins as potential pharmaceutical targets for therapeutic intervention in various diseases, among them cancer.

Experimental Design–Results: The vast array of information available for their molecular architecture and mode of action in various biological contexts, combined with the new opportunities offered by the flourishing technologies of structure-based drug design, computer-aided modeling, and functional genomics/proteomics, are creating an exciting scenery for the development of a novel generation of highly selective drugs.

Conclusions: This transcription factor-based therapeutic approach may revolutionize the anticancer drug options and will add significantly to the current clinical armamentarium.

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