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Clinical Cancer Research Vol. 8, 2879-2882, September 2002
© 2002 American Association for Cancer Research

Molecular Oncology, Markers, Clinical Correlates

Molecular Detection of Circulating Esophageal Squamous Cell Cancer Cells in the Peripheral Blood

Masahiko Koike, Kenji Hibi1, Yasushi Kasai, Katsuki Ito, Seiji Akiyama and Akimasa Nakao

Second Department of Surgery, Nagoya University School of Medicine, Nagoya 466-8550, Japan

Purpose and Experimental Design: To detect surgically resectable tumors earlier and improve the prognosis of esophageal squamous cell carcinoma patients, we examined {Delta}Np63 expression that was specific for squamous cell carcinoma in blood samples obtained from 43 esophageal cancer patients.

Results: Seventeen of 33 (52%) patients with primary esophageal squamous cell carcinoma and 6 of 10 (60%) patients with postoperative recurrent squamous cell carcinoma had detectable {Delta}Np63 expression in their peripheral blood using {Delta}Np63-specific reverse transcription-PCR. Furthermore, {Delta}Np63 is a more sensitive marker compared with other commonly used tumor markers such as squamous cell carcinoma-associated antigen and carcinoembryonic antigen.

Conclusions: This approach would be potentially useful for the monitoring of patients with this aggressive disease.




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Copyright © 2002 by the American Association for Cancer Research.